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Genetics of Parkinson's disease and parkinsonism.
Ann Neurol. 2006 Oct; 60(4):389-98.AN

Abstract

Until 10 years ago, conventional wisdom held that Parkinson's disease was not a genetic disorder. Since that time, there have been a plethora of genetic findings, culminating in the cloning of several genes that derive from the loci given the nomenclature PARK1-PARK12 (OMIM 168600). Recently, these research findings have begun to impact clinical practice, and this impact is likely to increase. The primary purpose of this article is to outline these genetic advances, discuss their importance for current practice in clinical and related settings, and outline briefly how they are influencing research into the causes of and possible future treatments for this prevalent disorder.

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Authors+Show Affiliations

Hardy J
Laboratory of Neurogenetics, National Institute on Aging, Porter Neuroscience Building, 35 Convent Drive, Bethesda, MD 20892, USA. hardyj@mail.nih.gov
Cai H
No affiliation info available
Cookson MR
No affiliation info available
Gwinn-Hardy K
No affiliation info available
Singleton A
No affiliation info available

MeSH

AgedHumansIntracellular Signaling Peptides and ProteinsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Oncogene ProteinsParkinson DiseaseParkinsonian DisordersProtein Deglycase DJ-1Protein KinasesProtein Serine-Threonine KinasesRiskUbiquitin-Protein Ligasesalpha-Synuclein

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural
Review

Language

eng

PubMed ID

17068789

Citation

Hardy, John, et al. "Genetics of Parkinson's Disease and Parkinsonism." Annals of Neurology, vol. 60, no. 4, 2006, pp. 389-98.
Hardy J, Cai H, Cookson MR, et al. Genetics of Parkinson's disease and parkinsonism. Ann Neurol. 2006;60(4):389-98.
Hardy, J., Cai, H., Cookson, M. R., Gwinn-Hardy, K., & Singleton, A. (2006). Genetics of Parkinson's disease and parkinsonism. Annals of Neurology, 60(4), 389-98.
Hardy J, et al. Genetics of Parkinson's Disease and Parkinsonism. Ann Neurol. 2006;60(4):389-98. PubMed PMID: 17068789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetics of Parkinson's disease and parkinsonism. AU - Hardy,John, AU - Cai,Huaiban, AU - Cookson,Mark R, AU - Gwinn-Hardy,Katrina, AU - Singleton,Andrew, PY - 2006/10/28/pubmed PY - 2006/12/9/medline PY - 2006/10/28/entrez SP - 389 EP - 98 JF - Annals of neurology JO - Ann Neurol VL - 60 IS - 4 N2 - Until 10 years ago, conventional wisdom held that Parkinson's disease was not a genetic disorder. Since that time, there have been a plethora of genetic findings, culminating in the cloning of several genes that derive from the loci given the nomenclature PARK1-PARK12 (OMIM 168600). Recently, these research findings have begun to impact clinical practice, and this impact is likely to increase. The primary purpose of this article is to outline these genetic advances, discuss their importance for current practice in clinical and related settings, and outline briefly how they are influencing research into the causes of and possible future treatments for this prevalent disorder. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/17068789/Genetics_of_Parkinson's_disease_and_parkinsonism_ L2 - https://doi.org/10.1002/ana.21022 DB - PRIME DP - Unbound Medicine ER -