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Measurement of extensive auditory discrimination profiles using the mismatch negativity (MMN) of the auditory event-related potential (ERP).
Clin Neurophysiol. 2007 Jan; 118(1):177-85.CN

Abstract

OBJECTIVE

Mismatch negativity (MMN), a change-specific component of the auditory event-related potential (ERP), is sensitive to deficits in central auditory processing associated with many clinical conditions. The aim of this study was to obtain a comprehensive multi-dimensional profile of central auditory processing by extending the recently developed fast multi-feature MMN paradigm [Näätänen R, Pakarinen S, Rinne T, Takegata R. The mismatch negativity (MMN): towards the optimal paradigm. Clin Neurophysiol 2004;115:140-144].

METHODS

MMN responses to changes in sound duration, frequency, intensity, and perceived sound-source location at six different magnitudes of deviation were recorded from healthy young adults by using the multi-feature MMN paradigm. In addition, behavioural discrimination accuracy and speed were measured to examine the relationship between MMN and behavioural performance.

RESULTS

All the 24 sound changes elicited significant MMNs. MMN amplitude increased and latency decreased with increasing magnitude of sound change. Furthermore, the MMN amplitude and latency predicted the subjects' accuracy and speed in detecting these deviations.

CONCLUSIONS

This new paradigm provides an extensive auditory discrimination profile for several auditory attributes at different deviation magnitudes in a minimal recording time.

SIGNIFICANCE

The auditory discrimination profiles can offer a comprehensive view of the development, plasticity, and deficits of central auditory processing.

Authors+Show Affiliations

Cognitive Brain Research Unit, Department of Psychology, University of Helsinki, P.O. Box 9, FIN-00014, Finland. satu.pakarinen@helsinki.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17070103

Citation

Pakarinen, Satu, et al. "Measurement of Extensive Auditory Discrimination Profiles Using the Mismatch Negativity (MMN) of the Auditory Event-related Potential (ERP)." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 118, no. 1, 2007, pp. 177-85.
Pakarinen S, Takegata R, Rinne T, et al. Measurement of extensive auditory discrimination profiles using the mismatch negativity (MMN) of the auditory event-related potential (ERP). Clin Neurophysiol. 2007;118(1):177-85.
Pakarinen, S., Takegata, R., Rinne, T., Huotilainen, M., & Näätänen, R. (2007). Measurement of extensive auditory discrimination profiles using the mismatch negativity (MMN) of the auditory event-related potential (ERP). Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 118(1), 177-85.
Pakarinen S, et al. Measurement of Extensive Auditory Discrimination Profiles Using the Mismatch Negativity (MMN) of the Auditory Event-related Potential (ERP). Clin Neurophysiol. 2007;118(1):177-85. PubMed PMID: 17070103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measurement of extensive auditory discrimination profiles using the mismatch negativity (MMN) of the auditory event-related potential (ERP). AU - Pakarinen,Satu, AU - Takegata,Rika, AU - Rinne,Teemu, AU - Huotilainen,Minna, AU - Näätänen,Risto, Y1 - 2006/10/27/ PY - 2005/07/01/received PY - 2006/08/30/revised PY - 2006/09/04/accepted PY - 2006/10/31/pubmed PY - 2007/3/28/medline PY - 2006/10/31/entrez SP - 177 EP - 85 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 118 IS - 1 N2 - OBJECTIVE: Mismatch negativity (MMN), a change-specific component of the auditory event-related potential (ERP), is sensitive to deficits in central auditory processing associated with many clinical conditions. The aim of this study was to obtain a comprehensive multi-dimensional profile of central auditory processing by extending the recently developed fast multi-feature MMN paradigm [Näätänen R, Pakarinen S, Rinne T, Takegata R. The mismatch negativity (MMN): towards the optimal paradigm. Clin Neurophysiol 2004;115:140-144]. METHODS: MMN responses to changes in sound duration, frequency, intensity, and perceived sound-source location at six different magnitudes of deviation were recorded from healthy young adults by using the multi-feature MMN paradigm. In addition, behavioural discrimination accuracy and speed were measured to examine the relationship between MMN and behavioural performance. RESULTS: All the 24 sound changes elicited significant MMNs. MMN amplitude increased and latency decreased with increasing magnitude of sound change. Furthermore, the MMN amplitude and latency predicted the subjects' accuracy and speed in detecting these deviations. CONCLUSIONS: This new paradigm provides an extensive auditory discrimination profile for several auditory attributes at different deviation magnitudes in a minimal recording time. SIGNIFICANCE: The auditory discrimination profiles can offer a comprehensive view of the development, plasticity, and deficits of central auditory processing. SN - 1388-2457 UR - https://www.unboundmedicine.com/medline/citation/17070103/Measurement_of_extensive_auditory_discrimination_profiles_using_the_mismatch_negativity__MMN__of_the_auditory_event_related_potential__ERP__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(06)01430-1 DB - PRIME DP - Unbound Medicine ER -