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Effects of mood stabilizers on the disruption of prepulse inhibition induced by apomorphine or dizocilpine in mice.
Eur J Pharmacol. 2006 Dec 28; 553(1-3):157-62.EJ

Abstract

The prepulse inhibition of the startle response provides an operational measure of sensorimotor gating in which a weak stimulus presented prior to a startling stimulus reduces the startle response. Prepulse inhibition deficits were observed in patients with several neuropsychiatric disorders, including schizophrenia and acute manic bipolar patients. Valproic acid, carbamazepine and lithium carbonate are frequently used as mood stabilizers in patients with bipolar affective disorder and schizophrenia. However, little is known about the mechanisms of action of mood stabilizers on prepulse inhibition deficits. In this study, we investigated the effects of mood stabilizers on the disruption of prepulse inhibition of the acoustic startle response induced by either apomorphine or dizocilpine in mice. Valproate (30-300 mg/kg, i.p.), carbamazepine (3-30 mg/kg, i.p.) and lithium carbonate (10-100 mg/kg, p.o.) had any effect on prepulse inhibition by itself. Valproate, carbamazepine and lithium carbonate reversed the disruption of prepulse inhibition induced by apomorphine (1 mg/kg, s.c.). Although valproate and carbamazepine had no effect on the disruption of prepulse inhibition induced by dizocilpine (0.3 mg/kg, s.c.), lithium carbonate exacerbated the dizocilpine-induced disruption. These results suggest that valproate, carbamazepine and lithium carbonate reverse the disruption of prepulse inhibition through the dopaminergic system.

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Authors+Show Affiliations

Umeda K
Department of Neuropharmacology Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Suemaru K
No affiliation info available
Todo N
No affiliation info available
Egashira N
No affiliation info available
Mishima K
No affiliation info available
Iwasaki K
No affiliation info available
Fujiwara M
No affiliation info available
Araki H
No affiliation info available

MeSH

AffectAnimalsAntimanic AgentsApomorphineCarbamazepineDizocilpine MaleateDopamine AgonistsDose-Response Relationship, DrugDrug InteractionsExcitatory Amino Acid AgonistsGABA AgentsLithium CarbonateMaleMiceReceptors, N-Methyl-D-AspartateReflex, StartleValproic Acid

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17070517

Citation

Umeda, Kenta, et al. "Effects of Mood Stabilizers On the Disruption of Prepulse Inhibition Induced By Apomorphine or Dizocilpine in Mice." European Journal of Pharmacology, vol. 553, no. 1-3, 2006, pp. 157-62.
Umeda K, Suemaru K, Todo N, et al. Effects of mood stabilizers on the disruption of prepulse inhibition induced by apomorphine or dizocilpine in mice. Eur J Pharmacol. 2006;553(1-3):157-62.
Umeda, K., Suemaru, K., Todo, N., Egashira, N., Mishima, K., Iwasaki, K., Fujiwara, M., & Araki, H. (2006). Effects of mood stabilizers on the disruption of prepulse inhibition induced by apomorphine or dizocilpine in mice. European Journal of Pharmacology, 553(1-3), 157-62.
Umeda K, et al. Effects of Mood Stabilizers On the Disruption of Prepulse Inhibition Induced By Apomorphine or Dizocilpine in Mice. Eur J Pharmacol. 2006 Dec 28;553(1-3):157-62. PubMed PMID: 17070517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of mood stabilizers on the disruption of prepulse inhibition induced by apomorphine or dizocilpine in mice. AU - Umeda,Kenta, AU - Suemaru,Katsuya, AU - Todo,Nobuko, AU - Egashira,Nobuaki, AU - Mishima,Kenichi, AU - Iwasaki,Katsunori, AU - Fujiwara,Michihiro, AU - Araki,Hiroaki, Y1 - 2006/09/28/ PY - 2006/03/27/received PY - 2006/09/11/revised PY - 2006/09/12/accepted PY - 2006/10/31/pubmed PY - 2007/1/25/medline PY - 2006/10/31/entrez SP - 157 EP - 62 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 553 IS - 1-3 N2 - The prepulse inhibition of the startle response provides an operational measure of sensorimotor gating in which a weak stimulus presented prior to a startling stimulus reduces the startle response. Prepulse inhibition deficits were observed in patients with several neuropsychiatric disorders, including schizophrenia and acute manic bipolar patients. Valproic acid, carbamazepine and lithium carbonate are frequently used as mood stabilizers in patients with bipolar affective disorder and schizophrenia. However, little is known about the mechanisms of action of mood stabilizers on prepulse inhibition deficits. In this study, we investigated the effects of mood stabilizers on the disruption of prepulse inhibition of the acoustic startle response induced by either apomorphine or dizocilpine in mice. Valproate (30-300 mg/kg, i.p.), carbamazepine (3-30 mg/kg, i.p.) and lithium carbonate (10-100 mg/kg, p.o.) had any effect on prepulse inhibition by itself. Valproate, carbamazepine and lithium carbonate reversed the disruption of prepulse inhibition induced by apomorphine (1 mg/kg, s.c.). Although valproate and carbamazepine had no effect on the disruption of prepulse inhibition induced by dizocilpine (0.3 mg/kg, s.c.), lithium carbonate exacerbated the dizocilpine-induced disruption. These results suggest that valproate, carbamazepine and lithium carbonate reverse the disruption of prepulse inhibition through the dopaminergic system. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/17070517/Effects_of_mood_stabilizers_on_the_disruption_of_prepulse_inhibition_induced_by_apomorphine_or_dizocilpine_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(06)01051-X DB - PRIME DP - Unbound Medicine ER -