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Characteristics of highly myopic eyes: the Beijing Eye Study.
Ophthalmology 2007; 114(1):121-6O

Abstract

OBJECTIVE

To evaluate factors associated with high myopia (defined as a myopic refractive error exceeding -8 diopters) in a population-based study.

DESIGN

Population-based prevalence study.

PARTICIPANTS

The Beijing Eye Study included 4439 participants from among 5324 individuals from a rural area and an urban region of Greater Beijing, > or =40 years old and invited to participate (response rate, 83.4%).

METHODS

Interview and detailed ophthalmic examination.

MAIN OUTCOME MEASURES

Refractive error, microvascular retinal abnormalities, optic disc morphometry, amount of cataract, and age-related macular changes.

RESULTS

Fundus photographs and data for refractive error were available for 4319 participants (97.3%; 8484 eyes). In binary logistic regression analysis, prevalence of high myopia was significantly associated with low best-corrected visual acuity (P<0.001; 95% confidence interval [CI], 0.15-0.40), large optic disc size (P<0.001; 95% CI, 1.64-2.25), large size of beta zone (P = 0.31; 95% CI, 1.45-1.75) and alpha zone of peripapillary atrophy (P<0.001; 95% CI, 1.20-1.58), and lower macular drusen count (P = 0.020; 95% CI, 0.81-0.98). The highly myopic group had a smaller mean size of macular drusen (P = 0.03; 95% CI, 0.02-0.26) and a smaller area covered by drusen (P = 0.01; 95% CI, 0.03-0.22). In the highly myopic group, the predominant drusen type was significantly (P = 0.01; 95% CI, 0.05-0.41) more often the hard distinct drusen type than the soft drusen type, and visual field defects were significantly more common (P<0.001; odds ratio [OR], 24.0; 95% CI, 13.9-41.4) and larger (P<0.001; 95% CI, -1.67 to -1.13). The frequencies of early macular degeneration (P = 0.03; OR, 3.0; 95% CI, 1.21-7.51) and late macular degeneration (P<0.001; OR, 6.33) were significantly lower in the highly myopic group than in the non-highly myopic group. High myopia was not significantly associated with gender (P = 0.18; 95% CI, 0.76-1.05), focal arteriolar thinning (P>0.35), arteriolar sheathing (P>0.45), arteriovenous crossing abnormalities (P>0.20), self-reported diagnosis of diabetes mellitus (P = 0.54; OR, 1.36; 95% CI, 0.48-3.80), or arterial hypertension (P = 0.34; OR, 0.66; 95% CI, 0.32-1.34).

CONCLUSIONS

In the adult Chinese population, high myopia is associated with a lower number, smaller, size and less advanced type of macular drusen, a larger optic nerve head, and decreased best-corrected visual acuity. The risk of early and late macular degeneration was lower for highly myopic participants than for non-highly myopic participants.

Authors+Show Affiliations

Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17070594

Citation

Xu, Liang, et al. "Characteristics of Highly Myopic Eyes: the Beijing Eye Study." Ophthalmology, vol. 114, no. 1, 2007, pp. 121-6.
Xu L, Li Y, Wang S, et al. Characteristics of highly myopic eyes: the Beijing Eye Study. Ophthalmology. 2007;114(1):121-6.
Xu, L., Li, Y., Wang, S., Wang, Y., Wang, Y., & Jonas, J. B. (2007). Characteristics of highly myopic eyes: the Beijing Eye Study. Ophthalmology, 114(1), pp. 121-6.
Xu L, et al. Characteristics of Highly Myopic Eyes: the Beijing Eye Study. Ophthalmology. 2007;114(1):121-6. PubMed PMID: 17070594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of highly myopic eyes: the Beijing Eye Study. AU - Xu,Liang, AU - Li,Yibin, AU - Wang,Shuang, AU - Wang,Yun, AU - Wang,Yaxin, AU - Jonas,Jost B, Y1 - 2006/10/27/ PY - 2006/03/06/received PY - 2006/05/09/revised PY - 2006/05/10/accepted PY - 2006/10/31/pubmed PY - 2007/1/17/medline PY - 2006/10/31/entrez SP - 121 EP - 6 JF - Ophthalmology JO - Ophthalmology VL - 114 IS - 1 N2 - OBJECTIVE: To evaluate factors associated with high myopia (defined as a myopic refractive error exceeding -8 diopters) in a population-based study. DESIGN: Population-based prevalence study. PARTICIPANTS: The Beijing Eye Study included 4439 participants from among 5324 individuals from a rural area and an urban region of Greater Beijing, > or =40 years old and invited to participate (response rate, 83.4%). METHODS: Interview and detailed ophthalmic examination. MAIN OUTCOME MEASURES: Refractive error, microvascular retinal abnormalities, optic disc morphometry, amount of cataract, and age-related macular changes. RESULTS: Fundus photographs and data for refractive error were available for 4319 participants (97.3%; 8484 eyes). In binary logistic regression analysis, prevalence of high myopia was significantly associated with low best-corrected visual acuity (P<0.001; 95% confidence interval [CI], 0.15-0.40), large optic disc size (P<0.001; 95% CI, 1.64-2.25), large size of beta zone (P = 0.31; 95% CI, 1.45-1.75) and alpha zone of peripapillary atrophy (P<0.001; 95% CI, 1.20-1.58), and lower macular drusen count (P = 0.020; 95% CI, 0.81-0.98). The highly myopic group had a smaller mean size of macular drusen (P = 0.03; 95% CI, 0.02-0.26) and a smaller area covered by drusen (P = 0.01; 95% CI, 0.03-0.22). In the highly myopic group, the predominant drusen type was significantly (P = 0.01; 95% CI, 0.05-0.41) more often the hard distinct drusen type than the soft drusen type, and visual field defects were significantly more common (P<0.001; odds ratio [OR], 24.0; 95% CI, 13.9-41.4) and larger (P<0.001; 95% CI, -1.67 to -1.13). The frequencies of early macular degeneration (P = 0.03; OR, 3.0; 95% CI, 1.21-7.51) and late macular degeneration (P<0.001; OR, 6.33) were significantly lower in the highly myopic group than in the non-highly myopic group. High myopia was not significantly associated with gender (P = 0.18; 95% CI, 0.76-1.05), focal arteriolar thinning (P>0.35), arteriolar sheathing (P>0.45), arteriovenous crossing abnormalities (P>0.20), self-reported diagnosis of diabetes mellitus (P = 0.54; OR, 1.36; 95% CI, 0.48-3.80), or arterial hypertension (P = 0.34; OR, 0.66; 95% CI, 0.32-1.34). CONCLUSIONS: In the adult Chinese population, high myopia is associated with a lower number, smaller, size and less advanced type of macular drusen, a larger optic nerve head, and decreased best-corrected visual acuity. The risk of early and late macular degeneration was lower for highly myopic participants than for non-highly myopic participants. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17070594/Characteristics_of_highly_myopic_eyes:_the_Beijing_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)00984-5 DB - PRIME DP - Unbound Medicine ER -