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Adiponectin is an independent determinant of insulin resistance in women with polycystic ovary syndrome.
Gynecol Endocrinol. 2006 Sep; 22(9):511-5.GE

Abstract

OBJECTIVE

Polycystic ovary syndrome (PCOS) is frequently associated with insulin resistance and a consequent increased risk of metabolic diseases. The aim of the present study was to investigate the role of adiponectin in insulin resistance in PCOS women.

MATERIALS AND METHODS

Forty-seven patients with PCOS and 23 control subjects, matched for age and body mass index (BMI), were enrolled in the study. Clinical, metabolic and hormonal parameters and adiponectin levels were measured, and HOMA-IR score (homeostasis model assessment-insulin resistance index) was calculated for each subject.

RESULTS

There was no difference in adiponectin levels between PCOS patients and the control group. However, adiponectin levels were negatively correlated with obesity-associated parameters and HOMA-IR score in PCOS patients and controls. As adiponectin is modulated by BMI we adjusted for BMI among the PCOS patients, and found a negative correlation between adiponectin levels and HOMA-IR score (r = -0.51, p < 0.001). Adiponectin and BMI were independent determinants of insulin resistance in PCOS patients (adjusted R2 = 0.66, p < 0.001).

CONCLUSION

Adiponectin did not seem to be actively involved in the pathogenesis of PCOS. However, adiponectin levels were independently associated with insulin resistance in PCOS patients, suggesting that adiponectin might play a role in the complicated metabolic abnormalities of PCOS.

Authors+Show Affiliations

Department of Endocrinology, Ankara Oncology Hospital, Ankara, Turkey. neseersoz@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17071536

Citation

Gulcelik, Nese Ersoz, et al. "Adiponectin Is an Independent Determinant of Insulin Resistance in Women With Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 22, no. 9, 2006, pp. 511-5.
Gulcelik NE, Aral Y, Serter R, et al. Adiponectin is an independent determinant of insulin resistance in women with polycystic ovary syndrome. Gynecol Endocrinol. 2006;22(9):511-5.
Gulcelik, N. E., Aral, Y., Serter, R., Demir, Y., & Culha, C. (2006). Adiponectin is an independent determinant of insulin resistance in women with polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 22(9), 511-5.
Gulcelik NE, et al. Adiponectin Is an Independent Determinant of Insulin Resistance in Women With Polycystic Ovary Syndrome. Gynecol Endocrinol. 2006;22(9):511-5. PubMed PMID: 17071536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adiponectin is an independent determinant of insulin resistance in women with polycystic ovary syndrome. AU - Gulcelik,Nese Ersoz, AU - Aral,Yalcin, AU - Serter,Rustu, AU - Demir,Yavuz, AU - Culha,Cavit, PY - 2006/10/31/pubmed PY - 2007/3/21/medline PY - 2006/10/31/entrez SP - 511 EP - 5 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 22 IS - 9 N2 - OBJECTIVE: Polycystic ovary syndrome (PCOS) is frequently associated with insulin resistance and a consequent increased risk of metabolic diseases. The aim of the present study was to investigate the role of adiponectin in insulin resistance in PCOS women. MATERIALS AND METHODS: Forty-seven patients with PCOS and 23 control subjects, matched for age and body mass index (BMI), were enrolled in the study. Clinical, metabolic and hormonal parameters and adiponectin levels were measured, and HOMA-IR score (homeostasis model assessment-insulin resistance index) was calculated for each subject. RESULTS: There was no difference in adiponectin levels between PCOS patients and the control group. However, adiponectin levels were negatively correlated with obesity-associated parameters and HOMA-IR score in PCOS patients and controls. As adiponectin is modulated by BMI we adjusted for BMI among the PCOS patients, and found a negative correlation between adiponectin levels and HOMA-IR score (r = -0.51, p < 0.001). Adiponectin and BMI were independent determinants of insulin resistance in PCOS patients (adjusted R2 = 0.66, p < 0.001). CONCLUSION: Adiponectin did not seem to be actively involved in the pathogenesis of PCOS. However, adiponectin levels were independently associated with insulin resistance in PCOS patients, suggesting that adiponectin might play a role in the complicated metabolic abnormalities of PCOS. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/17071536/Adiponectin_is_an_independent_determinant_of_insulin_resistance_in_women_with_polycystic_ovary_syndrome_ L2 - https://www.tandfonline.com/doi/full/10.1080/09513590600917943 DB - PRIME DP - Unbound Medicine ER -