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Clinical value of immunoglobulin A antitransglutaminase assay in the diagnosis of celiac disease.
Pediatrics 2006; 118(6):e1696-700Ped

Abstract

OBJECTIVES

Our goal was to evaluate the possible correspondence between antitissue transglutaminase of immunoglobulin A class levels and stage of mucosal damage in patients affected by celiac disease. In addition, we assessed clinical use of antitissue transglutaminase values to predict biopsy results.

METHODS

One thousand eight hundred eighty-six consecutive patients with symptoms suggestive of celiac disease and 305 healthy controls underwent determination of serum levels of immunoglobulin A and antitissue transglutaminase. An intestinal biopsy was performed in subjects with antitissue transglutaminase levels > or = 4 IU/mL and in subjects with negative antitissue transglutaminase levels but with clinical suspicion of celiac disease. Histologic grading of celiac disease was consistent with the Marsh classification.

RESULTS

One hundred eighty-six subjects with positive antitissue transglutaminase levels and 91 patients with negative antitissue transglutaminase levels were submitted to biopsy. In all healthy subjects, antitissue transglutaminase results were negative. Histologic evaluations in patients with positive antitissue transglutaminase levels gave the following results: type 0 in 25 patients, type 1 in 3 patients, type 2 in 4 patients, type 3a in 22 patients, type 3b in 74 patients, and type 3c in 58 patients. None of the patients with negative antitissue transglutaminase levels showed histologic findings suggestive of celiac disease. The mean antitissue transglutaminase values in patients without mucosal atrophy were significantly lower than in patients with mucosal atrophy. Antitissue transglutaminase values > or = 20 IU/mL were found in only 1 patient without mucosal atrophy.

CONCLUSIONS

Our study found a strong correspondence between antitissue transglutaminase levels and stage of mucosal injury; antitissue transglutaminase values > 20 IU/mL seemed to be strongly predictive of mucosal atrophy.

Authors+Show Affiliations

Gastroenterology and Nutrition Unit, Pediatric Hospital Bambino Gesù, Piazza S Onofrio, 4 00165 Rome, Italy. diamanti@opbg.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17074840

Citation

Diamanti, Antonella, et al. "Clinical Value of Immunoglobulin a Antitransglutaminase Assay in the Diagnosis of Celiac Disease." Pediatrics, vol. 118, no. 6, 2006, pp. e1696-700.
Diamanti A, Colistro F, Calce A, et al. Clinical value of immunoglobulin A antitransglutaminase assay in the diagnosis of celiac disease. Pediatrics. 2006;118(6):e1696-700.
Diamanti, A., Colistro, F., Calce, A., Devito, R., Ferretti, F., Minozzi, A., ... Castro, M. (2006). Clinical value of immunoglobulin A antitransglutaminase assay in the diagnosis of celiac disease. Pediatrics, 118(6), pp. e1696-700.
Diamanti A, et al. Clinical Value of Immunoglobulin a Antitransglutaminase Assay in the Diagnosis of Celiac Disease. Pediatrics. 2006;118(6):e1696-700. PubMed PMID: 17074840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical value of immunoglobulin A antitransglutaminase assay in the diagnosis of celiac disease. AU - Diamanti,Antonella, AU - Colistro,Franco, AU - Calce,Angelica, AU - Devito,Rita, AU - Ferretti,Francesca, AU - Minozzi,Antonio, AU - Santoni,Alexandra, AU - Castro,Massimo, Y1 - 2006/10/30/ PY - 2006/11/1/pubmed PY - 2006/12/21/medline PY - 2006/11/1/entrez SP - e1696 EP - 700 JF - Pediatrics JO - Pediatrics VL - 118 IS - 6 N2 - OBJECTIVES: Our goal was to evaluate the possible correspondence between antitissue transglutaminase of immunoglobulin A class levels and stage of mucosal damage in patients affected by celiac disease. In addition, we assessed clinical use of antitissue transglutaminase values to predict biopsy results. METHODS: One thousand eight hundred eighty-six consecutive patients with symptoms suggestive of celiac disease and 305 healthy controls underwent determination of serum levels of immunoglobulin A and antitissue transglutaminase. An intestinal biopsy was performed in subjects with antitissue transglutaminase levels > or = 4 IU/mL and in subjects with negative antitissue transglutaminase levels but with clinical suspicion of celiac disease. Histologic grading of celiac disease was consistent with the Marsh classification. RESULTS: One hundred eighty-six subjects with positive antitissue transglutaminase levels and 91 patients with negative antitissue transglutaminase levels were submitted to biopsy. In all healthy subjects, antitissue transglutaminase results were negative. Histologic evaluations in patients with positive antitissue transglutaminase levels gave the following results: type 0 in 25 patients, type 1 in 3 patients, type 2 in 4 patients, type 3a in 22 patients, type 3b in 74 patients, and type 3c in 58 patients. None of the patients with negative antitissue transglutaminase levels showed histologic findings suggestive of celiac disease. The mean antitissue transglutaminase values in patients without mucosal atrophy were significantly lower than in patients with mucosal atrophy. Antitissue transglutaminase values > or = 20 IU/mL were found in only 1 patient without mucosal atrophy. CONCLUSIONS: Our study found a strong correspondence between antitissue transglutaminase levels and stage of mucosal injury; antitissue transglutaminase values > 20 IU/mL seemed to be strongly predictive of mucosal atrophy. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/17074840/Clinical_value_of_immunoglobulin_A_antitransglutaminase_assay_in_the_diagnosis_of_celiac_disease_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=17074840 DB - PRIME DP - Unbound Medicine ER -