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Screening for celiac disease in Tunisian patients with Graves' disease using anti-endomysium and anti-tissue transglutaminase antibodies.
Gastroenterol Clin Biol 2006 Aug-Sep; 30(8-9):961-4GC

Abstract

OBJECTIVE

Celiac disease (CD) can be associated with autoimmune thyroid diseases. The aim of this study was to screen for CD in patients with Graves' disease in Tunisia.

PATIENTS AND METHODS

Sera from 161 patients with Graves' disease were tested for IgA class anti-endomysium antibodies (AEA) using indirect immunofluorescence on cryostat sections of human umbilical cord and for IgA class anti-human tissue transglutaminase antibodies (AtTG) by ELISA.

RESULTS

AEA were positive in 6 out of 161 (3.7%) patients with Graves' disease and all 6 patients were also positive for AtTG. Four of these 6 patients with positive serological markers of CD underwent duodenal biopsy; three had marked villous atrophy, one has normal histological picture and two did not agree to undergo biopsy. The prevalence of biopsy confirmed CD in patients with Graves' disease was 1.86% (3/161).

CONCLUSION

Patients with Graves' disease are at substantial risk of CD and therefore antibody screening for CD may be included in the work-up of these patients. Either AEA or AtTG may be used.

Authors+Show Affiliations

Department of Immunology, Research Unit (03/UR/07-02), Faculty of Pharmacy, Monastir.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17075442

Citation

Mankaï, Amani, et al. "Screening for Celiac Disease in Tunisian Patients With Graves' Disease Using Anti-endomysium and Anti-tissue Transglutaminase Antibodies." Gastroenterologie Clinique Et Biologique, vol. 30, no. 8-9, 2006, pp. 961-4.
Mankaï A, Chadli-Chaieb M, Saad F, et al. Screening for celiac disease in Tunisian patients with Graves' disease using anti-endomysium and anti-tissue transglutaminase antibodies. Gastroenterol Clin Biol. 2006;30(8-9):961-4.
Mankaï, A., Chadli-Chaieb, M., Saad, F., Ghedira-Besbes, L., Ouertani, M., Sfar, H., ... Ghedira, I. (2006). Screening for celiac disease in Tunisian patients with Graves' disease using anti-endomysium and anti-tissue transglutaminase antibodies. Gastroenterologie Clinique Et Biologique, 30(8-9), pp. 961-4.
Mankaï A, et al. Screening for Celiac Disease in Tunisian Patients With Graves' Disease Using Anti-endomysium and Anti-tissue Transglutaminase Antibodies. Gastroenterol Clin Biol. 2006;30(8-9):961-4. PubMed PMID: 17075442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening for celiac disease in Tunisian patients with Graves' disease using anti-endomysium and anti-tissue transglutaminase antibodies. AU - Mankaï,Amani, AU - Chadli-Chaieb,Molka, AU - Saad,Fathia, AU - Ghedira-Besbes,Leila, AU - Ouertani,Mohamed, AU - Sfar,Habib, AU - Limem,Monia, AU - Ben Abdessalem,Majda, AU - Jeddi,Moncef, AU - Chaieb,Larbi, AU - Ghedira,Ibtissem, PY - 2006/11/1/pubmed PY - 2006/12/21/medline PY - 2006/11/1/entrez SP - 961 EP - 4 JF - Gastroenterologie clinique et biologique JO - Gastroenterol. Clin. Biol. VL - 30 IS - 8-9 N2 - OBJECTIVE: Celiac disease (CD) can be associated with autoimmune thyroid diseases. The aim of this study was to screen for CD in patients with Graves' disease in Tunisia. PATIENTS AND METHODS: Sera from 161 patients with Graves' disease were tested for IgA class anti-endomysium antibodies (AEA) using indirect immunofluorescence on cryostat sections of human umbilical cord and for IgA class anti-human tissue transglutaminase antibodies (AtTG) by ELISA. RESULTS: AEA were positive in 6 out of 161 (3.7%) patients with Graves' disease and all 6 patients were also positive for AtTG. Four of these 6 patients with positive serological markers of CD underwent duodenal biopsy; three had marked villous atrophy, one has normal histological picture and two did not agree to undergo biopsy. The prevalence of biopsy confirmed CD in patients with Graves' disease was 1.86% (3/161). CONCLUSION: Patients with Graves' disease are at substantial risk of CD and therefore antibody screening for CD may be included in the work-up of these patients. Either AEA or AtTG may be used. SN - 0399-8320 UR - https://www.unboundmedicine.com/medline/citation/17075442/Screening_for_celiac_disease_in_Tunisian_patients_with_Graves'_disease_using_anti_endomysium_and_anti_tissue_transglutaminase_antibodies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/MDOI-GCB-08-2006-30-8-9-0399-8320-101019-200519196 DB - PRIME DP - Unbound Medicine ER -