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Screening for celiac disease in Tunisian patients with Graves' disease using anti-endomysium and anti-tissue transglutaminase antibodies.

Abstract

OBJECTIVE

Celiac disease (CD) can be associated with autoimmune thyroid diseases. The aim of this study was to screen for CD in patients with Graves' disease in Tunisia.

PATIENTS AND METHODS

Sera from 161 patients with Graves' disease were tested for IgA class anti-endomysium antibodies (AEA) using indirect immunofluorescence on cryostat sections of human umbilical cord and for IgA class anti-human tissue transglutaminase antibodies (AtTG) by ELISA.

RESULTS

AEA were positive in 6 out of 161 (3.7%) patients with Graves' disease and all 6 patients were also positive for AtTG. Four of these 6 patients with positive serological markers of CD underwent duodenal biopsy; three had marked villous atrophy, one has normal histological picture and two did not agree to undergo biopsy. The prevalence of biopsy confirmed CD in patients with Graves' disease was 1.86% (3/161).

CONCLUSION

Patients with Graves' disease are at substantial risk of CD and therefore antibody screening for CD may be included in the work-up of these patients. Either AEA or AtTG may be used.

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  • Authors+Show Affiliations

    ,

    Department of Immunology, Research Unit (03/UR/07-02), Faculty of Pharmacy, Monastir.

    , , , , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Autoantibodies
    Celiac Disease
    Child
    Female
    Graves Disease
    Humans
    Immunoglobulin A
    Male
    Mass Screening
    Middle Aged
    Transglutaminases
    Tunisia

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17075442

    Citation

    Mankaï, Amani, et al. "Screening for Celiac Disease in Tunisian Patients With Graves' Disease Using Anti-endomysium and Anti-tissue Transglutaminase Antibodies." Gastroenterologie Clinique Et Biologique, vol. 30, no. 8-9, 2006, pp. 961-4.
    Mankaï A, Chadli-Chaieb M, Saad F, et al. Screening for celiac disease in Tunisian patients with Graves' disease using anti-endomysium and anti-tissue transglutaminase antibodies. Gastroenterol Clin Biol. 2006;30(8-9):961-4.
    Mankaï, A., Chadli-Chaieb, M., Saad, F., Ghedira-Besbes, L., Ouertani, M., Sfar, H., ... Ghedira, I. (2006). Screening for celiac disease in Tunisian patients with Graves' disease using anti-endomysium and anti-tissue transglutaminase antibodies. Gastroenterologie Clinique Et Biologique, 30(8-9), pp. 961-4.
    Mankaï A, et al. Screening for Celiac Disease in Tunisian Patients With Graves' Disease Using Anti-endomysium and Anti-tissue Transglutaminase Antibodies. Gastroenterol Clin Biol. 2006;30(8-9):961-4. PubMed PMID: 17075442.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Screening for celiac disease in Tunisian patients with Graves' disease using anti-endomysium and anti-tissue transglutaminase antibodies. AU - Mankaï,Amani, AU - Chadli-Chaieb,Molka, AU - Saad,Fathia, AU - Ghedira-Besbes,Leila, AU - Ouertani,Mohamed, AU - Sfar,Habib, AU - Limem,Monia, AU - Ben Abdessalem,Majda, AU - Jeddi,Moncef, AU - Chaieb,Larbi, AU - Ghedira,Ibtissem, PY - 2006/11/1/pubmed PY - 2006/12/21/medline PY - 2006/11/1/entrez SP - 961 EP - 4 JF - Gastroenterologie clinique et biologique JO - Gastroenterol. Clin. Biol. VL - 30 IS - 8-9 N2 - OBJECTIVE: Celiac disease (CD) can be associated with autoimmune thyroid diseases. The aim of this study was to screen for CD in patients with Graves' disease in Tunisia. PATIENTS AND METHODS: Sera from 161 patients with Graves' disease were tested for IgA class anti-endomysium antibodies (AEA) using indirect immunofluorescence on cryostat sections of human umbilical cord and for IgA class anti-human tissue transglutaminase antibodies (AtTG) by ELISA. RESULTS: AEA were positive in 6 out of 161 (3.7%) patients with Graves' disease and all 6 patients were also positive for AtTG. Four of these 6 patients with positive serological markers of CD underwent duodenal biopsy; three had marked villous atrophy, one has normal histological picture and two did not agree to undergo biopsy. The prevalence of biopsy confirmed CD in patients with Graves' disease was 1.86% (3/161). CONCLUSION: Patients with Graves' disease are at substantial risk of CD and therefore antibody screening for CD may be included in the work-up of these patients. Either AEA or AtTG may be used. SN - 0399-8320 UR - https://www.unboundmedicine.com/medline/citation/17075442/Screening_for_celiac_disease_in_Tunisian_patients_with_Graves'_disease_using_anti_endomysium_and_anti_tissue_transglutaminase_antibodies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/MDOI-GCB-08-2006-30-8-9-0399-8320-101019-200519196 DB - PRIME DP - Unbound Medicine ER -