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The augmentation of clozapine treatment with electroconvulsive therapy.
Ideggyogy Sz. 2006 Jul 20; 59(7-8):261-7.IS

Abstract

OBJECTIVES

The assessment, in terms of safety and efficacy, of augmenting clozapine monotherapy, as well as combined psychopharmacotherapy involving clozapine, with electroconvulsive therapy (ECT).

METHOD

Reviewed were the charts of patients who received clozapine-ECT treatment in the Department of Psychiatry and Psychotherapy of Semmelweis University between November 1999 and December 2003.

RESULTS

During the studied period there were altogether 43 patients treated with the combination of clozapine and electroconvulsive therapy. In the schizoaffective group, the values for post-electroconvulsive therapy CGI were significantly lower than either in the catatonic (Z=-3.72, p<0.01) or in the hebephrenic (Z=-3.17, p<0.01) group. Among the groups created on the basis of the number of augmentation strategies utilized, the clozapine+3 group consisted of patients significantly older than the clozapine+ 1 group (Z=2.45, p=0.01). In the clozapine monotherapy group, the values for post-electroconvulsive therapy CGI were significantly lower than in any of the groups that had received a combination of augmentations (monotherapy-1 augmentation: Z=-3.01, p<0.01; monotherapy-2 augmentation: Z=-2.89, p<0.01; monotherapy-3 augmentation: Z=-2.41, p=0.01).

CONCLUSIONS

According to our examinations, the augmentation of clozapine treatment with electroconvulsive therapy should be tried primarily on schizoaffective patients, in case the clozapine monotherapy is ineffective. The simultaneous use of different augmentation strategies is expected to increase only the side effects not the efficacy of the treatment.

Authors+Show Affiliations

Gazdag G
Liaison Psychiatric Service, Szent László Hospital, Budapest. gazdag@lamb.hu
Kocsis-Ficzere N
No affiliation info available
Tolna J
No affiliation info available

MeSH

AdultAgedAntipsychotic AgentsClozapineCombined Modality TherapyDrug Therapy, CombinationElectroconvulsive TherapyFemaleHumansMaleMedical RecordsMiddle AgedPsychotic DisordersResearch DesignRetrospective StudiesSchizophreniaTreatment Outcome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17076304

Citation

Gazdag, Gábor, et al. "The Augmentation of Clozapine Treatment With Electroconvulsive Therapy." Ideggyogyaszati Szemle, vol. 59, no. 7-8, 2006, pp. 261-7.
Gazdag G, Kocsis-Ficzere N, Tolna J. The augmentation of clozapine treatment with electroconvulsive therapy. Ideggyogy Sz. 2006;59(7-8):261-7.
Gazdag, G., Kocsis-Ficzere, N., & Tolna, J. (2006). The augmentation of clozapine treatment with electroconvulsive therapy. Ideggyogyaszati Szemle, 59(7-8), 261-7.
Gazdag G, Kocsis-Ficzere N, Tolna J. The Augmentation of Clozapine Treatment With Electroconvulsive Therapy. Ideggyogy Sz. 2006 Jul 20;59(7-8):261-7. PubMed PMID: 17076304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The augmentation of clozapine treatment with electroconvulsive therapy. AU - Gazdag,Gábor, AU - Kocsis-Ficzere,Nárcisz, AU - Tolna,Judit, PY - 2006/11/2/pubmed PY - 2007/3/31/medline PY - 2006/11/2/entrez SP - 261 EP - 7 JF - Ideggyogyaszati szemle JO - Ideggyogy Sz VL - 59 IS - 7-8 N2 - OBJECTIVES: The assessment, in terms of safety and efficacy, of augmenting clozapine monotherapy, as well as combined psychopharmacotherapy involving clozapine, with electroconvulsive therapy (ECT). METHOD: Reviewed were the charts of patients who received clozapine-ECT treatment in the Department of Psychiatry and Psychotherapy of Semmelweis University between November 1999 and December 2003. RESULTS: During the studied period there were altogether 43 patients treated with the combination of clozapine and electroconvulsive therapy. In the schizoaffective group, the values for post-electroconvulsive therapy CGI were significantly lower than either in the catatonic (Z=-3.72, p<0.01) or in the hebephrenic (Z=-3.17, p<0.01) group. Among the groups created on the basis of the number of augmentation strategies utilized, the clozapine+3 group consisted of patients significantly older than the clozapine+ 1 group (Z=2.45, p=0.01). In the clozapine monotherapy group, the values for post-electroconvulsive therapy CGI were significantly lower than in any of the groups that had received a combination of augmentations (monotherapy-1 augmentation: Z=-3.01, p<0.01; monotherapy-2 augmentation: Z=-2.89, p<0.01; monotherapy-3 augmentation: Z=-2.41, p=0.01). CONCLUSIONS: According to our examinations, the augmentation of clozapine treatment with electroconvulsive therapy should be tried primarily on schizoaffective patients, in case the clozapine monotherapy is ineffective. The simultaneous use of different augmentation strategies is expected to increase only the side effects not the efficacy of the treatment. SN - 0019-1442 UR - https://www.unboundmedicine.com/medline/citation/17076304/The_augmentation_of_clozapine_treatment_with_electroconvulsive_therapy_ DB - PRIME DP - Unbound Medicine ER -