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Physical activity and the 15-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study.

Abstract

BACKGROUND

Cardiovascular disease and age-related macular degeneration (AMD) may share common risk factors. Physical activity improves the cardiovascular risk profile; however, there have been few studies investigating a relationship between physical activity and the long-term incidence of AMD.

METHODS

The 15-year cumulative incidence of AMD was determined through four examination phases at 5-year intervals of a population-based study conducted in Beaver Dam, Wisconsin, USA, initiated in 1988-90 (n = 3874 men and women between ages 43 and 86 years). Early AMD (pigment abnormalities or soft indistinct drusen), exudative AMD and geographic atrophy were determined by grading stereoscopic colour fundus photographs. Measures of physical activity were obtained through a questionnaire administered at the baseline examination.

RESULTS

After controlling for age, sex, history of arthritis, systolic blood pressure, body mass index, smoking and education, people with an active lifestyle (defined as regular activity > or =3 times/week) at baseline were less likely to develop exudative AMD (odds ratio (OR) 0.3, 95% confidence interval (CI) 0.1 to 0.7) compared with people without an active lifestyle. After multivariate adjustment, increased categories of number of blocks walked per day decreased the risk of exudative AMD (OR 0.7, 95% CI 0.6 to 0.97). Physical activity was not related to the incidence of early AMD or pure geographic atrophy.

CONCLUSIONS

These data show a protective effect of physical activity for incident exudative AMD, independent of body mass index and other confounders. They also suggest a possible modifiable behaviour that might be protective against developing AMD.

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  • Authors+Show Affiliations

    ,

    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health,, Madison, WI 53726-2336, USA. knudtson@epi.ophth.wisc.edu

    ,

    Source

    The British journal of ophthalmology 90:12 2006 Dec pg 1461-3

    MeSH

    Adult
    Age Factors
    Aged
    Aged, 80 and over
    Exercise
    Female
    Follow-Up Studies
    Humans
    Incidence
    Life Style
    Macular Degeneration
    Male
    Middle Aged
    Motor Activity
    Risk Factors
    Walking
    Wisconsin

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17077116

    Citation

    Knudtson, M D., et al. "Physical Activity and the 15-year Cumulative Incidence of Age-related Macular Degeneration: the Beaver Dam Eye Study." The British Journal of Ophthalmology, vol. 90, no. 12, 2006, pp. 1461-3.
    Knudtson MD, Klein R, Klein BE. Physical activity and the 15-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. Br J Ophthalmol. 2006;90(12):1461-3.
    Knudtson, M. D., Klein, R., & Klein, B. E. (2006). Physical activity and the 15-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. The British Journal of Ophthalmology, 90(12), pp. 1461-3.
    Knudtson MD, Klein R, Klein BE. Physical Activity and the 15-year Cumulative Incidence of Age-related Macular Degeneration: the Beaver Dam Eye Study. Br J Ophthalmol. 2006;90(12):1461-3. PubMed PMID: 17077116.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Physical activity and the 15-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. AU - Knudtson,M D, AU - Klein,R, AU - Klein,B E K, Y1 - 2006/10/31/ PY - 2006/11/2/pubmed PY - 2006/12/12/medline PY - 2006/11/2/entrez SP - 1461 EP - 3 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 90 IS - 12 N2 - BACKGROUND: Cardiovascular disease and age-related macular degeneration (AMD) may share common risk factors. Physical activity improves the cardiovascular risk profile; however, there have been few studies investigating a relationship between physical activity and the long-term incidence of AMD. METHODS: The 15-year cumulative incidence of AMD was determined through four examination phases at 5-year intervals of a population-based study conducted in Beaver Dam, Wisconsin, USA, initiated in 1988-90 (n = 3874 men and women between ages 43 and 86 years). Early AMD (pigment abnormalities or soft indistinct drusen), exudative AMD and geographic atrophy were determined by grading stereoscopic colour fundus photographs. Measures of physical activity were obtained through a questionnaire administered at the baseline examination. RESULTS: After controlling for age, sex, history of arthritis, systolic blood pressure, body mass index, smoking and education, people with an active lifestyle (defined as regular activity > or =3 times/week) at baseline were less likely to develop exudative AMD (odds ratio (OR) 0.3, 95% confidence interval (CI) 0.1 to 0.7) compared with people without an active lifestyle. After multivariate adjustment, increased categories of number of blocks walked per day decreased the risk of exudative AMD (OR 0.7, 95% CI 0.6 to 0.97). Physical activity was not related to the incidence of early AMD or pure geographic atrophy. CONCLUSIONS: These data show a protective effect of physical activity for incident exudative AMD, independent of body mass index and other confounders. They also suggest a possible modifiable behaviour that might be protective against developing AMD. SN - 0007-1161 UR - https://www.unboundmedicine.com/medline/citation/17077116/full_citation L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=17077116 DB - PRIME DP - Unbound Medicine ER -