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Iron intake and risk of ovulatory infertility.
Obstet Gynecol 2006; 108(5):1145-52OG

Abstract

OBJECTIVE

To evaluate whether iron supplement use or greater intake of total, heme and nonheme iron is associated with lower risk of ovulatory infertility.

METHODS

We conducted a prospective cohort study among 18,555 married, premenopausal women without a history of infertility who attempted a pregnancy or became pregnant between 1991 and 1999 (mean baseline age+/-standard deviation 32.6+/-3.6). Diet was assessed twice during follow-up and prospectively related to the incidence of infertility due to ovulatory disorder.

RESULTS

During the 8 years of follow-up, 438 women reported infertility due to ovulatory disorder. Women who consumed iron supplements had a significantly lower risk of ovulatory infertility than women who did not use iron supplements (relative risk 0.60, 95% confidence interval 0.39-0.92), after adjusting for potential confounders. Total nonheme iron intake, primarily consumed as multivitamins and iron supplements, was inversely associated with the risk of infertility (relative risk Quintile 1 compared with 5, 95% confidence interval 0.39-0.92; P, trend .005.) Heme iron intake was unrelated to ovulatory infertility in multivariable adjusted analyses.

CONCLUSION

Consumption of iron supplements and nonheme iron from other sources may decrease the risk of ovulatory infertility.

LEVEL OF EVIDENCE

II-2.

Authors+Show Affiliations

Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA. jchavarr@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17077236

Citation

Chavarro, Jorge E., et al. "Iron Intake and Risk of Ovulatory Infertility." Obstetrics and Gynecology, vol. 108, no. 5, 2006, pp. 1145-52.
Chavarro JE, Rich-Edwards JW, Rosner BA, et al. Iron intake and risk of ovulatory infertility. Obstet Gynecol. 2006;108(5):1145-52.
Chavarro, J. E., Rich-Edwards, J. W., Rosner, B. A., & Willett, W. C. (2006). Iron intake and risk of ovulatory infertility. Obstetrics and Gynecology, 108(5), pp. 1145-52.
Chavarro JE, et al. Iron Intake and Risk of Ovulatory Infertility. Obstet Gynecol. 2006;108(5):1145-52. PubMed PMID: 17077236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron intake and risk of ovulatory infertility. AU - Chavarro,Jorge E, AU - Rich-Edwards,Janet W, AU - Rosner,Bernard A, AU - Willett,Walter C, PY - 2006/11/2/pubmed PY - 2006/12/9/medline PY - 2006/11/2/entrez SP - 1145 EP - 52 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 108 IS - 5 N2 - OBJECTIVE: To evaluate whether iron supplement use or greater intake of total, heme and nonheme iron is associated with lower risk of ovulatory infertility. METHODS: We conducted a prospective cohort study among 18,555 married, premenopausal women without a history of infertility who attempted a pregnancy or became pregnant between 1991 and 1999 (mean baseline age+/-standard deviation 32.6+/-3.6). Diet was assessed twice during follow-up and prospectively related to the incidence of infertility due to ovulatory disorder. RESULTS: During the 8 years of follow-up, 438 women reported infertility due to ovulatory disorder. Women who consumed iron supplements had a significantly lower risk of ovulatory infertility than women who did not use iron supplements (relative risk 0.60, 95% confidence interval 0.39-0.92), after adjusting for potential confounders. Total nonheme iron intake, primarily consumed as multivitamins and iron supplements, was inversely associated with the risk of infertility (relative risk Quintile 1 compared with 5, 95% confidence interval 0.39-0.92; P, trend .005.) Heme iron intake was unrelated to ovulatory infertility in multivariable adjusted analyses. CONCLUSION: Consumption of iron supplements and nonheme iron from other sources may decrease the risk of ovulatory infertility. LEVEL OF EVIDENCE: II-2. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/17077236/Iron_intake_and_risk_of_ovulatory_infertility_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=17077236.ui DB - PRIME DP - Unbound Medicine ER -