Tags

Type your tag names separated by a space and hit enter

Particle design of three-component system for sustained release using a 4-fluid nozzle spray-drying technique.
Chem Pharm Bull (Tokyo). 2006 Nov; 54(11):1486-90.CP

Abstract

We prepared composite particles of acetaminophen (Act) with chitosan (Cht) and hydroxypropylmethylcellulose phthalate (HPMCP) as a carrier using a newly developed 4-fluid nozzle spray-dryer. Cht dissolves in acid solutions and forms a gel, but it is insoluble in alkaline solutions. On the other hand, HPMCP is insoluble in acid solutions, but it dissolves in alkaline solutions. Therefore, we tested a preparation of controlled release composite particles using the characteristics of these carriers. Act and Cht mixtures in prescribed ratios were dissolved in an acid solution. Composite particles of Act and HPMCP in prescribed ratios were dissolved in alkaline solutions. We evaluated the composite particles of the three components (Act, Cht, and HPMCP) by preparing solid dispersions using a 4-fluid nozzle spray-dryer. Observation of particle morphology by scanning electron microscopy (SEM) revealed that the particles from the spray-drying process had atomized to several microns and had all become spherical. We investigated the physical properties of the composite particles by powder X-ray diffraction, differential scanning calorimetry, and dissolution rate analysis to clarify the effects of crystallinity on the dissolution rate. Powder X-ray diffraction peaks and the heat of fusion of Act in the spray-dried samples decreased in proportion to the carrier content, indicating that the drug was amorphous. These results indicate that the Act-Cht-HPMCP system formed a solid dispersion. Furthermore, we investigated the interaction between the drug and the carrier using FT-IR analysis. FT-IR spectroscopy of the Act solid dispersions suggested that the Act carbonyl and Cht amino groups formed a hydrogen bond. On the other hand, interaction by hydrogen bond was observed between the carbonyl group of HPMCP with the amino group of Act. In the three-component Act-Cht-HPMCP system, the 4-fluid nozzle spray-dried preparation with a mixing ratio of 1 : 2.5 : 2.5 obtained sustained release preparation in all pH test solutions.

Authors+Show Affiliations

Mintai Chemical Co., Ltd., Bah-Der City, Taoyuan Hsien, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17077544

Citation

Chen, Richer, et al. "Particle Design of Three-component System for Sustained Release Using a 4-fluid Nozzle Spray-drying Technique." Chemical & Pharmaceutical Bulletin, vol. 54, no. 11, 2006, pp. 1486-90.
Chen R, Takahashi H, Okamoto H, et al. Particle design of three-component system for sustained release using a 4-fluid nozzle spray-drying technique. Chem Pharm Bull. 2006;54(11):1486-90.
Chen, R., Takahashi, H., Okamoto, H., & Danjo, K. (2006). Particle design of three-component system for sustained release using a 4-fluid nozzle spray-drying technique. Chemical & Pharmaceutical Bulletin, 54(11), 1486-90.
Chen R, et al. Particle Design of Three-component System for Sustained Release Using a 4-fluid Nozzle Spray-drying Technique. Chem Pharm Bull. 2006;54(11):1486-90. PubMed PMID: 17077544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Particle design of three-component system for sustained release using a 4-fluid nozzle spray-drying technique. AU - Chen,Richer, AU - Takahashi,Hirokazu, AU - Okamoto,Hirokazu, AU - Danjo,Kazumi, PY - 2006/11/2/pubmed PY - 2007/2/9/medline PY - 2006/11/2/entrez SP - 1486 EP - 90 JF - Chemical & pharmaceutical bulletin JO - Chem. Pharm. Bull. VL - 54 IS - 11 N2 - We prepared composite particles of acetaminophen (Act) with chitosan (Cht) and hydroxypropylmethylcellulose phthalate (HPMCP) as a carrier using a newly developed 4-fluid nozzle spray-dryer. Cht dissolves in acid solutions and forms a gel, but it is insoluble in alkaline solutions. On the other hand, HPMCP is insoluble in acid solutions, but it dissolves in alkaline solutions. Therefore, we tested a preparation of controlled release composite particles using the characteristics of these carriers. Act and Cht mixtures in prescribed ratios were dissolved in an acid solution. Composite particles of Act and HPMCP in prescribed ratios were dissolved in alkaline solutions. We evaluated the composite particles of the three components (Act, Cht, and HPMCP) by preparing solid dispersions using a 4-fluid nozzle spray-dryer. Observation of particle morphology by scanning electron microscopy (SEM) revealed that the particles from the spray-drying process had atomized to several microns and had all become spherical. We investigated the physical properties of the composite particles by powder X-ray diffraction, differential scanning calorimetry, and dissolution rate analysis to clarify the effects of crystallinity on the dissolution rate. Powder X-ray diffraction peaks and the heat of fusion of Act in the spray-dried samples decreased in proportion to the carrier content, indicating that the drug was amorphous. These results indicate that the Act-Cht-HPMCP system formed a solid dispersion. Furthermore, we investigated the interaction between the drug and the carrier using FT-IR analysis. FT-IR spectroscopy of the Act solid dispersions suggested that the Act carbonyl and Cht amino groups formed a hydrogen bond. On the other hand, interaction by hydrogen bond was observed between the carbonyl group of HPMCP with the amino group of Act. In the three-component Act-Cht-HPMCP system, the 4-fluid nozzle spray-dried preparation with a mixing ratio of 1 : 2.5 : 2.5 obtained sustained release preparation in all pH test solutions. SN - 0009-2363 UR - https://www.unboundmedicine.com/medline/citation/17077544/Particle_design_of_three_component_system_for_sustained_release_using_a_4_fluid_nozzle_spray_drying_technique_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/cpb/54.1486?from=PubMed DB - PRIME DP - Unbound Medicine ER -