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Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models.
Yakugaku Zasshi. 2006 Nov; 126(11):1171-8.YZ

Abstract

AIM

The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of chloroform extract of Solanum nigrum leaves using various animal models.

METHODS

The extract was prepared by soaking (1:20; w/v) the air-dried powdered leaves (20 g) in chloroform for 72 hrs followed by evaporation (40 degrees C) under reduced pressure to dryness (1.26 g) and then dissolved (1:50; w/v) in dimethylsulfoxide (DMSO). The supernatant, considered as the stock solution with dose of 200 mg/kg, was diluted using DMSO to 20 and 100 mg/kg, and all doses were administered (s.c.; 10 ml/kg) in mice/rats 30 min prior to tests.

RESULTS

The extract exhibited significant (p<0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (p<0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests. Overall, the activities occurred in a dose-independent manner.

CONCLUSION

The present study demonstrated that the lipid-soluble extract of S. nigrum leaves possessed antinociceptive, anti-inflammatory and anti-pyretic properties and confirmed the traditional claims.

Authors+Show Affiliations

Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor, Jalan Zirkon A7/A, Seksyen 7, 40000 Shah Alam, Selangor, Malaysia. shaza8174@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17077618

Citation

Zakaria, Zainul Amiruddin, et al. "Antinociceptive, Anti-inflammatory and Antipyretic Effects of Solanum Nigrum Chloroform Extract in Animal Models." Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, vol. 126, no. 11, 2006, pp. 1171-8.
Zakaria ZA, Gopalan HK, Zainal H, et al. Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models. Yakugaku Zasshi. 2006;126(11):1171-8.
Zakaria, Z. A., Gopalan, H. K., Zainal, H., Mohd Pojan, N. H., Morsid, N. A., Aris, A., & Sulaiman, M. R. (2006). Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, 126(11), 1171-8.
Zakaria ZA, et al. Antinociceptive, Anti-inflammatory and Antipyretic Effects of Solanum Nigrum Chloroform Extract in Animal Models. Yakugaku Zasshi. 2006;126(11):1171-8. PubMed PMID: 17077618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models. AU - Zakaria,Zainul Amiruddin, AU - Gopalan,Hanan Kumar, AU - Zainal,Hairani, AU - Mohd Pojan,Nur Hidayu, AU - Morsid,Nur Atiqah, AU - Aris,Anwariah, AU - Sulaiman,Mohd Roslan, PY - 2006/11/2/pubmed PY - 2007/1/27/medline PY - 2006/11/2/entrez SP - 1171 EP - 8 JF - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan JO - Yakugaku Zasshi VL - 126 IS - 11 N2 - AIM: The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of chloroform extract of Solanum nigrum leaves using various animal models. METHODS: The extract was prepared by soaking (1:20; w/v) the air-dried powdered leaves (20 g) in chloroform for 72 hrs followed by evaporation (40 degrees C) under reduced pressure to dryness (1.26 g) and then dissolved (1:50; w/v) in dimethylsulfoxide (DMSO). The supernatant, considered as the stock solution with dose of 200 mg/kg, was diluted using DMSO to 20 and 100 mg/kg, and all doses were administered (s.c.; 10 ml/kg) in mice/rats 30 min prior to tests. RESULTS: The extract exhibited significant (p<0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (p<0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests. Overall, the activities occurred in a dose-independent manner. CONCLUSION: The present study demonstrated that the lipid-soluble extract of S. nigrum leaves possessed antinociceptive, anti-inflammatory and anti-pyretic properties and confirmed the traditional claims. SN - 0031-6903 UR - https://www.unboundmedicine.com/medline/citation/17077618/Antinociceptive_anti_inflammatory_and_antipyretic_effects_of_Solanum_nigrum_chloroform_extract_in_animal_models_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/yakushi/126.1171?from=PubMed&amp;lang=en DB - PRIME DP - Unbound Medicine ER -