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Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals.
Yakugaku Zasshi. 2006 Nov; 126(11):1197-203.YZ

Abstract

The present study was carried out to establish the antinociceptive and anti-inflammatory properties of Dicranopteris linearis leaves chloroform extract in experimental animals. The antinociceptive activity was measured using the abdominal constriction, formalin and hot plate tests, while the anti-inflammatory activity was measured using the carrageenan-induced paw edema. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by evaporation under vacuo (40 degrees C) to dryness, was dissolved in dimethyl sulfoxide to the doses of 20, 100 and 200 mg/kg and administered subcutaneously 30 min prior to subjection to the above mentioned assays. The extract, at all doses used, was found to exhibit significant (p<0.05) antinociceptive activity in a dose-dependent manner. However, the significant (p<0.05) anti-inflammatory activity observed occur in a dose-independent manner. As a conclusion, the chloroform extract of D. linearis possesses antinociceptive and anti-inflammatory activity and thus justify its traditional uses by the Malays to treat various ailments.

Authors+Show Affiliations

Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor, Jalan Zirkon A7/A, Seksyen 7, 40000 Shah Alam, Selangor, Malaysia. shaza8174@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17077622

Citation

Zakaria, Zainul Amiruddin, et al. "Antinociceptive and Anti-inflammatory Activities of Dicranopteris Linearis Leaves Chloroform Extract in Experimental Animals." Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, vol. 126, no. 11, 2006, pp. 1197-203.
Zakaria ZA, Abdul Ghani ZD, Raden Mohd Nor RN, et al. Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals. Yakugaku Zasshi. 2006;126(11):1197-203.
Zakaria, Z. A., Abdul Ghani, Z. D., Raden Mohd Nor, R. N., Gopalan, H. K., Sulaiman, M. R., & Abdullah, F. C. (2006). Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, 126(11), 1197-203.
Zakaria ZA, et al. Antinociceptive and Anti-inflammatory Activities of Dicranopteris Linearis Leaves Chloroform Extract in Experimental Animals. Yakugaku Zasshi. 2006;126(11):1197-203. PubMed PMID: 17077622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals. AU - Zakaria,Zainul Amiruddin, AU - Abdul Ghani,Zuleen Delina Fasya, AU - Raden Mohd Nor,Raden Nur Suraya, AU - Gopalan,Hanan Kumar, AU - Sulaiman,Mohd Roslan, AU - Abdullah,Fatimah Corazon, PY - 2006/11/2/pubmed PY - 2007/1/27/medline PY - 2006/11/2/entrez SP - 1197 EP - 203 JF - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan JO - Yakugaku Zasshi VL - 126 IS - 11 N2 - The present study was carried out to establish the antinociceptive and anti-inflammatory properties of Dicranopteris linearis leaves chloroform extract in experimental animals. The antinociceptive activity was measured using the abdominal constriction, formalin and hot plate tests, while the anti-inflammatory activity was measured using the carrageenan-induced paw edema. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by evaporation under vacuo (40 degrees C) to dryness, was dissolved in dimethyl sulfoxide to the doses of 20, 100 and 200 mg/kg and administered subcutaneously 30 min prior to subjection to the above mentioned assays. The extract, at all doses used, was found to exhibit significant (p<0.05) antinociceptive activity in a dose-dependent manner. However, the significant (p<0.05) anti-inflammatory activity observed occur in a dose-independent manner. As a conclusion, the chloroform extract of D. linearis possesses antinociceptive and anti-inflammatory activity and thus justify its traditional uses by the Malays to treat various ailments. SN - 0031-6903 UR - https://www.unboundmedicine.com/medline/citation/17077622/Antinociceptive_and_anti_inflammatory_activities_of_Dicranopteris_linearis_leaves_chloroform_extract_in_experimental_animals_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/yakushi/126.1197?from=PubMed&amp;lang=en DB - PRIME DP - Unbound Medicine ER -