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Epstein-Barr virus BZLF1 gene, a switch from latency to lytic infection, is expressed as an immediate-early gene after primary infection of B lymphocytes.
J Virol. 2007 Jan; 81(2):1037-42.JV

Abstract

We demonstrate here that the Epstein-Barr virus (EBV) BZLF1 gene, a switch from latent infection to lytic infection, is expressed as early as 1.5 h after EBV infection in Burkitt's lymphoma-derived, EBV-negative Akata and Daudi cells and primary B lymphocytes. Since BZLF1 mRNA is expressed even when the cells are infected with EBV in the presence of anisomycin, an inhibitor of protein synthesis, its expression does not require prerequisite protein synthesis, indicating that BZLF1 is expressed as an immediate-early gene following primary EBV infection of B lymphocytes.

Authors+Show Affiliations

Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17079287

Citation

Wen, Wangrong, et al. "Epstein-Barr Virus BZLF1 Gene, a Switch From Latency to Lytic Infection, Is Expressed as an Immediate-early Gene After Primary Infection of B Lymphocytes." Journal of Virology, vol. 81, no. 2, 2007, pp. 1037-42.
Wen W, Iwakiri D, Yamamoto K, et al. Epstein-Barr virus BZLF1 gene, a switch from latency to lytic infection, is expressed as an immediate-early gene after primary infection of B lymphocytes. J Virol. 2007;81(2):1037-42.
Wen, W., Iwakiri, D., Yamamoto, K., Maruo, S., Kanda, T., & Takada, K. (2007). Epstein-Barr virus BZLF1 gene, a switch from latency to lytic infection, is expressed as an immediate-early gene after primary infection of B lymphocytes. Journal of Virology, 81(2), 1037-42.
Wen W, et al. Epstein-Barr Virus BZLF1 Gene, a Switch From Latency to Lytic Infection, Is Expressed as an Immediate-early Gene After Primary Infection of B Lymphocytes. J Virol. 2007;81(2):1037-42. PubMed PMID: 17079287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epstein-Barr virus BZLF1 gene, a switch from latency to lytic infection, is expressed as an immediate-early gene after primary infection of B lymphocytes. AU - Wen,Wangrong, AU - Iwakiri,Dai, AU - Yamamoto,Koji, AU - Maruo,Seiji, AU - Kanda,Teru, AU - Takada,Kenzo, Y1 - 2006/11/01/ PY - 2006/11/3/pubmed PY - 2007/2/3/medline PY - 2006/11/3/entrez SP - 1037 EP - 42 JF - Journal of virology JO - J. Virol. VL - 81 IS - 2 N2 - We demonstrate here that the Epstein-Barr virus (EBV) BZLF1 gene, a switch from latent infection to lytic infection, is expressed as early as 1.5 h after EBV infection in Burkitt's lymphoma-derived, EBV-negative Akata and Daudi cells and primary B lymphocytes. Since BZLF1 mRNA is expressed even when the cells are infected with EBV in the presence of anisomycin, an inhibitor of protein synthesis, its expression does not require prerequisite protein synthesis, indicating that BZLF1 is expressed as an immediate-early gene following primary EBV infection of B lymphocytes. SN - 0022-538X UR - https://www.unboundmedicine.com/medline/citation/17079287/Epstein_Barr_virus_BZLF1_gene_a_switch_from_latency_to_lytic_infection_is_expressed_as_an_immediate_early_gene_after_primary_infection_of_B_lymphocytes_ L2 - http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=17079287 DB - PRIME DP - Unbound Medicine ER -