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Subthalamic nucleus stimulation is efficacious in patients with Parkinsonism and LRRK2 mutations.
Mov Disord. 2007 Jan; 22(1):119-22.MD

Abstract

Stimulation of the subthalamic nucleus (STN) improves motor signs in patients with levodopa-responsive Parkinson's disease (PD). Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause Parkinsonism. We assessed 69 patients under STN stimulation and found heterozygous LRRK2 mutations in 9 (G2019S in 8 and T2031S in 1). The age at onset of PD, the clinical characteristics before or after neurosurgery, and the clinical response to STN stimulation were similar in both groups. Two patients with the G2019S LRRK2 mutation still benefited from STN stimulation, 9 and 10 years after surgery. Patients with LRRK2 mutations are, therefore, good candidates for STN stimulation.

Authors+Show Affiliations

Centre d'Investigation Clinique, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17080443

Citation

Schüpbach, Michael, et al. "Subthalamic Nucleus Stimulation Is Efficacious in Patients With Parkinsonism and LRRK2 Mutations." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 22, no. 1, 2007, pp. 119-22.
Schüpbach M, Lohmann E, Anheim M, et al. Subthalamic nucleus stimulation is efficacious in patients with Parkinsonism and LRRK2 mutations. Mov Disord. 2007;22(1):119-22.
Schüpbach, M., Lohmann, E., Anheim, M., Lesage, S., Czernecki, V., Yaici, S., Worbe, Y., Charles, P., Welter, M. L., Pollak, P., Dürr, A., Agid, Y., & Brice, A. (2007). Subthalamic nucleus stimulation is efficacious in patients with Parkinsonism and LRRK2 mutations. Movement Disorders : Official Journal of the Movement Disorder Society, 22(1), 119-22.
Schüpbach M, et al. Subthalamic Nucleus Stimulation Is Efficacious in Patients With Parkinsonism and LRRK2 Mutations. Mov Disord. 2007;22(1):119-22. PubMed PMID: 17080443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subthalamic nucleus stimulation is efficacious in patients with Parkinsonism and LRRK2 mutations. AU - Schüpbach,Michael, AU - Lohmann,Ebba, AU - Anheim,Mathieu, AU - Lesage,Suzanne, AU - Czernecki,Virginie, AU - Yaici,Sadek, AU - Worbe,Yulia, AU - Charles,Perrine, AU - Welter,Marie-Laure, AU - Pollak,Pierre, AU - Dürr,Alexandra, AU - Agid,Yves, AU - Brice,Alexis, PY - 2006/11/3/pubmed PY - 2007/4/6/medline PY - 2006/11/3/entrez SP - 119 EP - 22 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 22 IS - 1 N2 - Stimulation of the subthalamic nucleus (STN) improves motor signs in patients with levodopa-responsive Parkinson's disease (PD). Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause Parkinsonism. We assessed 69 patients under STN stimulation and found heterozygous LRRK2 mutations in 9 (G2019S in 8 and T2031S in 1). The age at onset of PD, the clinical characteristics before or after neurosurgery, and the clinical response to STN stimulation were similar in both groups. Two patients with the G2019S LRRK2 mutation still benefited from STN stimulation, 9 and 10 years after surgery. Patients with LRRK2 mutations are, therefore, good candidates for STN stimulation. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/17080443/Subthalamic_nucleus_stimulation_is_efficacious_in_patients_with_Parkinsonism_and_LRRK2_mutations_ L2 - https://doi.org/10.1002/mds.21178 DB - PRIME DP - Unbound Medicine ER -