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Cocoa flavanol-enriched snack bars containing phytosterols effectively lower total and low-density lipoprotein cholesterol levels.
J Am Diet Assoc. 2006 Nov; 106(11):1804-13.JA

Abstract

BACKGROUND

Dietary intervention studies incorporating phytosterol-enriched margarine spreads have reported significant decreases in total and low-density lipoprotein (LDL) cholesterol in populations with both normal lipid levels and those with hypercholesterolemia. There is emerging support for more diverse and lower-fat phytosterol-enriched matrixes. Controversy exists, however, over whether phytosterol-enriched foods affect serum fat-soluble vitamins.

OBJECTIVE

We investigated whether a flavanol-rich cocoa snack food containing phytosterols would decrease total and LDL cholesterol levels in subjects with hypercholesterolemia and significantly affect serum fat-soluble vitamins and carotenoids.

DESIGN

A randomized, double-blind parallel arm study design was used. Subjects were randomized to one of two dietary treatments: a cocoa flavanol-enriched snack bar containing 1.5 g phytosterol (n=32), or a control product containing no phytosterols (n=35). Subjects consumed two servings per day.

RESULTS

Consumption of the phytosterol-enriched snack bars but not control bars for 6 weeks was associated with significant reductions in plasma total (4.7%; P<0.01) and LDL cholesterol (6%; P<0.01), and the ratio of total to high-density lipoprotein cholesterol (7.4%; P<0.001). There were no changes in high-density lipoprotein cholesterol, triglycerides, or lipid-adjusted lycopene, beta-cryptoxanthin, lutein/zeaxanthin, alpha-carotene levels, or levels of serum vitamins A or E. A significant reduction in lipid-adjusted serum beta-carotene was observed in the phytosterol but not the no-phytosterol-added group (P<0.05).

CONCLUSIONS

This study supports the use of a novel phytosterol-enriched snack bar to effectively reduce plasma total and LDL cholesterol levels in a population with hypercholesterolemia. The data suggest that the incorporation of this snack food into a balanced diet represents a practical dietary strategy in the management of serum cholesterol levels.

Authors+Show Affiliations

Department of Nutrition, University of California, Davis, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17081832

Citation

Polagruto, John A., et al. "Cocoa Flavanol-enriched Snack Bars Containing Phytosterols Effectively Lower Total and Low-density Lipoprotein Cholesterol Levels." Journal of the American Dietetic Association, vol. 106, no. 11, 2006, pp. 1804-13.
Polagruto JA, Wang-Polagruto JF, Braun MM, et al. Cocoa flavanol-enriched snack bars containing phytosterols effectively lower total and low-density lipoprotein cholesterol levels. J Am Diet Assoc. 2006;106(11):1804-13.
Polagruto, J. A., Wang-Polagruto, J. F., Braun, M. M., Lee, L., Kwik-Uribe, C., & Keen, C. L. (2006). Cocoa flavanol-enriched snack bars containing phytosterols effectively lower total and low-density lipoprotein cholesterol levels. Journal of the American Dietetic Association, 106(11), 1804-13.
Polagruto JA, et al. Cocoa Flavanol-enriched Snack Bars Containing Phytosterols Effectively Lower Total and Low-density Lipoprotein Cholesterol Levels. J Am Diet Assoc. 2006;106(11):1804-13. PubMed PMID: 17081832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cocoa flavanol-enriched snack bars containing phytosterols effectively lower total and low-density lipoprotein cholesterol levels. AU - Polagruto,John A, AU - Wang-Polagruto,Janice F, AU - Braun,Marlia M, AU - Lee,Luke, AU - Kwik-Uribe,Catherine, AU - Keen,Carl L, PY - 2005/09/28/received PY - 2006/11/4/pubmed PY - 2006/12/9/medline PY - 2006/11/4/entrez SP - 1804 EP - 13 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 106 IS - 11 N2 - BACKGROUND: Dietary intervention studies incorporating phytosterol-enriched margarine spreads have reported significant decreases in total and low-density lipoprotein (LDL) cholesterol in populations with both normal lipid levels and those with hypercholesterolemia. There is emerging support for more diverse and lower-fat phytosterol-enriched matrixes. Controversy exists, however, over whether phytosterol-enriched foods affect serum fat-soluble vitamins. OBJECTIVE: We investigated whether a flavanol-rich cocoa snack food containing phytosterols would decrease total and LDL cholesterol levels in subjects with hypercholesterolemia and significantly affect serum fat-soluble vitamins and carotenoids. DESIGN: A randomized, double-blind parallel arm study design was used. Subjects were randomized to one of two dietary treatments: a cocoa flavanol-enriched snack bar containing 1.5 g phytosterol (n=32), or a control product containing no phytosterols (n=35). Subjects consumed two servings per day. RESULTS: Consumption of the phytosterol-enriched snack bars but not control bars for 6 weeks was associated with significant reductions in plasma total (4.7%; P<0.01) and LDL cholesterol (6%; P<0.01), and the ratio of total to high-density lipoprotein cholesterol (7.4%; P<0.001). There were no changes in high-density lipoprotein cholesterol, triglycerides, or lipid-adjusted lycopene, beta-cryptoxanthin, lutein/zeaxanthin, alpha-carotene levels, or levels of serum vitamins A or E. A significant reduction in lipid-adjusted serum beta-carotene was observed in the phytosterol but not the no-phytosterol-added group (P<0.05). CONCLUSIONS: This study supports the use of a novel phytosterol-enriched snack bar to effectively reduce plasma total and LDL cholesterol levels in a population with hypercholesterolemia. The data suggest that the incorporation of this snack food into a balanced diet represents a practical dietary strategy in the management of serum cholesterol levels. SN - 0002-8223 UR - https://www.unboundmedicine.com/medline/citation/17081832/Cocoa_flavanol_enriched_snack_bars_containing_phytosterols_effectively_lower_total_and_low_density_lipoprotein_cholesterol_levels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8223(06)01836-0 DB - PRIME DP - Unbound Medicine ER -