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A century of Alzheimer's disease.
Science. 2006 Nov 03; 314(5800):777-81.Sci

Abstract

One hundred years ago a small group of psychiatrists described the abnormal protein deposits in the brain that define the most common neurodegenerative diseases. Over the past 25 years, it has become clear that the proteins forming the deposits are central to the disease process. Amyloid-beta and tau make up the plaques and tangles of Alzheimer's disease, where these normally soluble proteins assemble into amyloid-like filaments. Tau inclusions are also found in a number of related disorders. Genetic studies have shown that dysfunction of amyloid-beta or tau is sufficient to cause dementia. The ongoing molecular dissection of the neurodegenerative pathways is expected to lead to a true understanding of disease pathogenesis.

Authors+Show Affiliations

Laboratory of Molecular Biology, Medical Research Council, Cambridge CB2 2QH, UK. mg@mrc-lmb.cam.ac.ukNo affiliation info available

Pub Type(s)

Historical Article
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17082447

Citation

Goedert, Michel, and Maria Grazia Spillantini. "A Century of Alzheimer's Disease." Science (New York, N.Y.), vol. 314, no. 5800, 2006, pp. 777-81.
Goedert M, Spillantini MG. A century of Alzheimer's disease. Science. 2006;314(5800):777-81.
Goedert, M., & Spillantini, M. G. (2006). A century of Alzheimer's disease. Science (New York, N.Y.), 314(5800), 777-81.
Goedert M, Spillantini MG. A Century of Alzheimer's Disease. Science. 2006 Nov 3;314(5800):777-81. PubMed PMID: 17082447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A century of Alzheimer's disease. AU - Goedert,Michel, AU - Spillantini,Maria Grazia, PY - 2006/11/4/pubmed PY - 2006/12/9/medline PY - 2006/11/4/entrez SP - 777 EP - 81 JF - Science (New York, N.Y.) JO - Science VL - 314 IS - 5800 N2 - One hundred years ago a small group of psychiatrists described the abnormal protein deposits in the brain that define the most common neurodegenerative diseases. Over the past 25 years, it has become clear that the proteins forming the deposits are central to the disease process. Amyloid-beta and tau make up the plaques and tangles of Alzheimer's disease, where these normally soluble proteins assemble into amyloid-like filaments. Tau inclusions are also found in a number of related disorders. Genetic studies have shown that dysfunction of amyloid-beta or tau is sufficient to cause dementia. The ongoing molecular dissection of the neurodegenerative pathways is expected to lead to a true understanding of disease pathogenesis. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/17082447/A_century_of_Alzheimer's_disease_ L2 - http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=17082447 DB - PRIME DP - Unbound Medicine ER -