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Evaluation of developmental toxicity of amitraz in Sprague-Dawley rats.
Arch Environ Contam Toxicol. 2007 Jan; 52(1):137-44.AE

Abstract

This study investigated the potential adverse effects of amitraz on the initiation and maintenance of pregnancy in Sprague-Dawley rats as well as its effects on embryo-fetal development after maternal exposure during the entire pregnancy period. Amitraz was administered to pregnant rats by gavage from days 1 to 19 of gestation at dose levels of 0, 3, 10, and 30 mg/kg/day. All dams underwent a caesarean section on day 20 of gestation and their fetuses were examined for any external, visceral, and skeletal abnormalities. At 30 mg/kg, maternal toxicity manifested as an increase in the incidence of abnormal clinical signs and a lower body weight gain and food intake. Developmental toxicity included an increase in the fetal death rate, a decrease in the litter size, and a reduction in the fetal body weight. In addition, there was an increase in the incidence of fetal external, visceral, and skeletal abnormalities. At 10 mg/kg, maternal toxicity observed included a decrease in the body weight gain and a decrease in food intake. In addition, minimal developmental toxicity, including a decrease in the fetal body weight, an increase in the visceral and skeletal aberrations, and a delay in fetal ossification. There were no signs of either maternal toxicity or developmental toxicity at 3 mg/kg. These results show that amitraz administered during the entire pregnancy period in rats is embryotoxic and teratogenic at the maternally toxic dose (i.e., 30 mg/kg/day) and is minimally embryotoxic at a minimally maternally toxic dose (i.e., 10 mg/kg/day). Under these experimental conditions, the no-observed-adverse-effect level of amitraz for both dams and embryo-fetal development is estimated to be 3 mg/kg/day.

Authors+Show Affiliations

College of Veterinary Medicine, Chonnam National University, Gwangju, 500-757, South Korea. toxkim@chonnam.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17083001

Citation

Kim, J C., et al. "Evaluation of Developmental Toxicity of Amitraz in Sprague-Dawley Rats." Archives of Environmental Contamination and Toxicology, vol. 52, no. 1, 2007, pp. 137-44.
Kim JC, Shin JY, Yang YS, et al. Evaluation of developmental toxicity of amitraz in Sprague-Dawley rats. Arch Environ Contam Toxicol. 2007;52(1):137-44.
Kim, J. C., Shin, J. Y., Yang, Y. S., Shin, D. H., Moon, C. J., Kim, S. H., Park, S. C., Kim, Y. B., Kim, H. C., & Chung, M. K. (2007). Evaluation of developmental toxicity of amitraz in Sprague-Dawley rats. Archives of Environmental Contamination and Toxicology, 52(1), 137-44.
Kim JC, et al. Evaluation of Developmental Toxicity of Amitraz in Sprague-Dawley Rats. Arch Environ Contam Toxicol. 2007;52(1):137-44. PubMed PMID: 17083001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of developmental toxicity of amitraz in Sprague-Dawley rats. AU - Kim,J C, AU - Shin,J Y, AU - Yang,Y S, AU - Shin,D H, AU - Moon,C J, AU - Kim,S H, AU - Park,S C, AU - Kim,Y B, AU - Kim,H C, AU - Chung,M K, Y1 - 2006/11/02/ PY - 2006/02/03/received PY - 2006/07/12/accepted PY - 2006/11/4/pubmed PY - 2007/2/13/medline PY - 2006/11/4/entrez SP - 137 EP - 44 JF - Archives of environmental contamination and toxicology JO - Arch Environ Contam Toxicol VL - 52 IS - 1 N2 - This study investigated the potential adverse effects of amitraz on the initiation and maintenance of pregnancy in Sprague-Dawley rats as well as its effects on embryo-fetal development after maternal exposure during the entire pregnancy period. Amitraz was administered to pregnant rats by gavage from days 1 to 19 of gestation at dose levels of 0, 3, 10, and 30 mg/kg/day. All dams underwent a caesarean section on day 20 of gestation and their fetuses were examined for any external, visceral, and skeletal abnormalities. At 30 mg/kg, maternal toxicity manifested as an increase in the incidence of abnormal clinical signs and a lower body weight gain and food intake. Developmental toxicity included an increase in the fetal death rate, a decrease in the litter size, and a reduction in the fetal body weight. In addition, there was an increase in the incidence of fetal external, visceral, and skeletal abnormalities. At 10 mg/kg, maternal toxicity observed included a decrease in the body weight gain and a decrease in food intake. In addition, minimal developmental toxicity, including a decrease in the fetal body weight, an increase in the visceral and skeletal aberrations, and a delay in fetal ossification. There were no signs of either maternal toxicity or developmental toxicity at 3 mg/kg. These results show that amitraz administered during the entire pregnancy period in rats is embryotoxic and teratogenic at the maternally toxic dose (i.e., 30 mg/kg/day) and is minimally embryotoxic at a minimally maternally toxic dose (i.e., 10 mg/kg/day). Under these experimental conditions, the no-observed-adverse-effect level of amitraz for both dams and embryo-fetal development is estimated to be 3 mg/kg/day. SN - 0090-4341 UR - https://www.unboundmedicine.com/medline/citation/17083001/Evaluation_of_developmental_toxicity_of_amitraz_in_Sprague_Dawley_rats_ L2 - https://dx.doi.org/10.1007/s00244-006-0021-7 DB - PRIME DP - Unbound Medicine ER -