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[Tumor necrosis factor-alpha system in patients with gestational diabetes].
Przegl Lek 2006; 63(4):173-5PL

Abstract

Tumor necrosis factor-alpha (TNF-alpha) system is potentially involved in the development of insulin resistance during pregnancy. Plasma concentrations of TNF-alpha and its soluble receptors sTNFR-1 and sTNFR-2 were measured in 80 patients with gestational diabetes (GDM) (mean age 29.0 +/- 4.9 years) and 30 pregnant women with normal glucose tolerance (NGT) (mean age 28.2 +/- 6.0 years). We found that patients with GDM had significantly higher levels of TNF-alpha in comparison to NGT women (1.71+/- 0.92 vs. 1.27 +/- 0.42 pg/ml, p = 0.0175). The differences remained statistically significant after adjusting for BMI (p = 0.027). Plasma levels of sTNFR-1 and sTNFR-2 were only slightly higher in patients with GDM (2.83 +/- 0.79 ng/ml vs. 2.55 +/- 0.99 ng/ ml, p = 0.057 and 7.46 +/- 2.21 ng/ml vs. 6.83 +/- 1.46 ng/ml, p=0.206, respectively). In the group with GDM TNF-alpha concentrations correlated with sTNFR-1 (r = 0.444, p = 0.00008), sTNFR-2 (r = 0.364, p = 0.0016) and with C-peptide concentrations (r = 0.318, p = 0.016), whereas in women with NGT - only with triglyceride levels (r = 0.50, p = 0.024). Multivariate linear regression analysis revealed that early pregnancy BMI was the most predictive indicator of TNF-alpha concentrations in GDM women (p=0.008). In NTG group triglyceride concentrations, as well as BMI in early pregnancy and at the time of sampling were significant predictors, explaining together 62% of the variance in TNF-alpha concentration. In conclusion, increased TNF-alpha concentrations in women with GDM class G1 indicates its contribution to the development of insulin resistance during pregnancy, but the lack of the differences in sTNFR concentrations between the groups studied suggests only moderate TNF-alpha system activation in relatively slim patients treated with diet.

Authors+Show Affiliations

Zakład Patofizjologii Ciazy, Akademii Medycznej w Białymstoku.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

17083157

Citation

Kinalski, Maciej, et al. "[Tumor Necrosis Factor-alpha System in Patients With Gestational Diabetes]." Przeglad Lekarski, vol. 63, no. 4, 2006, pp. 173-5.
Kinalski M, Kuźmicki M, Telejko B, et al. [Tumor necrosis factor-alpha system in patients with gestational diabetes]. Prz Lek. 2006;63(4):173-5.
Kinalski, M., Kuźmicki, M., Telejko, B., Bachórzewski, R., Buraczyk, M., Kretowski, A., & Kinalska, I. (2006). [Tumor necrosis factor-alpha system in patients with gestational diabetes]. Przeglad Lekarski, 63(4), pp. 173-5.
Kinalski M, et al. [Tumor Necrosis Factor-alpha System in Patients With Gestational Diabetes]. Prz Lek. 2006;63(4):173-5. PubMed PMID: 17083157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Tumor necrosis factor-alpha system in patients with gestational diabetes]. AU - Kinalski,Maciej, AU - Kuźmicki,Mariusz, AU - Telejko,Beata, AU - Bachórzewski,Rafał, AU - Buraczyk,Malgorzata, AU - Kretowski,Adam, AU - Kinalska,Ida, PY - 2006/11/4/pubmed PY - 2006/12/27/medline PY - 2006/11/4/entrez SP - 173 EP - 5 JF - Przeglad lekarski JO - Prz. Lek. VL - 63 IS - 4 N2 - Tumor necrosis factor-alpha (TNF-alpha) system is potentially involved in the development of insulin resistance during pregnancy. Plasma concentrations of TNF-alpha and its soluble receptors sTNFR-1 and sTNFR-2 were measured in 80 patients with gestational diabetes (GDM) (mean age 29.0 +/- 4.9 years) and 30 pregnant women with normal glucose tolerance (NGT) (mean age 28.2 +/- 6.0 years). We found that patients with GDM had significantly higher levels of TNF-alpha in comparison to NGT women (1.71+/- 0.92 vs. 1.27 +/- 0.42 pg/ml, p = 0.0175). The differences remained statistically significant after adjusting for BMI (p = 0.027). Plasma levels of sTNFR-1 and sTNFR-2 were only slightly higher in patients with GDM (2.83 +/- 0.79 ng/ml vs. 2.55 +/- 0.99 ng/ ml, p = 0.057 and 7.46 +/- 2.21 ng/ml vs. 6.83 +/- 1.46 ng/ml, p=0.206, respectively). In the group with GDM TNF-alpha concentrations correlated with sTNFR-1 (r = 0.444, p = 0.00008), sTNFR-2 (r = 0.364, p = 0.0016) and with C-peptide concentrations (r = 0.318, p = 0.016), whereas in women with NGT - only with triglyceride levels (r = 0.50, p = 0.024). Multivariate linear regression analysis revealed that early pregnancy BMI was the most predictive indicator of TNF-alpha concentrations in GDM women (p=0.008). In NTG group triglyceride concentrations, as well as BMI in early pregnancy and at the time of sampling were significant predictors, explaining together 62% of the variance in TNF-alpha concentration. In conclusion, increased TNF-alpha concentrations in women with GDM class G1 indicates its contribution to the development of insulin resistance during pregnancy, but the lack of the differences in sTNFR concentrations between the groups studied suggests only moderate TNF-alpha system activation in relatively slim patients treated with diet. SN - 0033-2240 UR - https://www.unboundmedicine.com/medline/citation/17083157/[Tumor_necrosis_factor_alpha_system_in_patients_with_gestational_diabetes]_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -