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Influence of ethanol on aspirin release from hypromellose matrices.
Int J Pharm. 2007 Mar 06; 332(1-2):31-7.IJ

Abstract

Release profiles of aspirin from hypromellose matrices in hydro-ethanolic media were studied. Percent aspirin released increased with increasing levels of ethanol in the dissolution media, correlating with the drug's solubility, however, dose dumping of aspirin did not occur. An initial rapid release was observed in media comprising 40% ethanol. Release in these conditions was considered to be both erosion and diffusion-mediated, in contrast to the release in 0, 10, 20 and 30% ethanol media, where erosion-controlled release dominated. Image analysis of matrix swelling indicated a slower initial interaction between ethanol and hypromellose accounting for the initial rapid release. Cloud point studies suggested that ethanol retarded hydration of the polymer.

Authors+Show Affiliations

School of Pharmacy and Chemistry, Liverpool John Moores University, Byrom St. L3 3AF, UK. M.Roberts1@ljmu.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17084050

Citation

Roberts, Matthew, et al. "Influence of Ethanol On Aspirin Release From Hypromellose Matrices." International Journal of Pharmaceutics, vol. 332, no. 1-2, 2007, pp. 31-7.
Roberts M, Cespi M, Ford JL, et al. Influence of ethanol on aspirin release from hypromellose matrices. Int J Pharm. 2007;332(1-2):31-7.
Roberts, M., Cespi, M., Ford, J. L., Dyas, A. M., Downing, J., Martini, L. G., & Crowley, P. J. (2007). Influence of ethanol on aspirin release from hypromellose matrices. International Journal of Pharmaceutics, 332(1-2), 31-7.
Roberts M, et al. Influence of Ethanol On Aspirin Release From Hypromellose Matrices. Int J Pharm. 2007 Mar 6;332(1-2):31-7. PubMed PMID: 17084050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of ethanol on aspirin release from hypromellose matrices. AU - Roberts,Matthew, AU - Cespi,Marco, AU - Ford,James L, AU - Dyas,A Mark, AU - Downing,James, AU - Martini,Luigi G, AU - Crowley,Patrick J, Y1 - 2006/10/06/ PY - 2006/06/06/received PY - 2006/09/11/revised PY - 2006/09/11/accepted PY - 2006/11/7/pubmed PY - 2007/5/10/medline PY - 2006/11/7/entrez SP - 31 EP - 7 JF - International journal of pharmaceutics JO - Int J Pharm VL - 332 IS - 1-2 N2 - Release profiles of aspirin from hypromellose matrices in hydro-ethanolic media were studied. Percent aspirin released increased with increasing levels of ethanol in the dissolution media, correlating with the drug's solubility, however, dose dumping of aspirin did not occur. An initial rapid release was observed in media comprising 40% ethanol. Release in these conditions was considered to be both erosion and diffusion-mediated, in contrast to the release in 0, 10, 20 and 30% ethanol media, where erosion-controlled release dominated. Image analysis of matrix swelling indicated a slower initial interaction between ethanol and hypromellose accounting for the initial rapid release. Cloud point studies suggested that ethanol retarded hydration of the polymer. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/17084050/Influence_of_ethanol_on_aspirin_release_from_hypromellose_matrices_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(06)00790-3 DB - PRIME DP - Unbound Medicine ER -