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Tumor necrosis factor-alpha induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: the role of NF-kappa B, JNK and p38 MAPK.
Neuropharmacology. 2007 Mar; 52(3):708-15.N

Abstract

Compelling evidence has shown that in hippocampus tumor necrosis factor alpha (TNF-alpha) at pathological concentration inhibits long-term potentiation (LTP), a synaptic model of learning and memory. In the present work we investigated the role of TNF-alpha in LTP of C-fiber evoked field potentials in spinal dorsal horn, which is relevant to pathological pain. We showed that spinal application of TNF-alpha affected neither basal synaptic transmission mediated by C-fibers nor spinal LTP of C-fiber evoked field potentials induced by tetanic stimulation in intact rats. However, in rats with neuropathic pain, produced by either lumbar 5 ventral root transection (L5 VRT) or spared nerve injury (SNI), spinal application of TNF-alpha induced LTP of C-fiber evoked field potentials. Spinal application of JNK inhibitor (SP600125) or p38 MAPK inhibitor (SB203580) did not affect the spinal LTP induced by tetanic stimulation in intact rats, but completely blocked LTP induced by TNF-alpha in L5 VRT rats. NF-kappa B (NF-kappaB) inhibitor (PDTC) also blocked LTP induced by TNF-alpha. These results suggest that TNF-alpha and its downstream molecules may have no acute effect on spinal synaptic transmission in intact animals and induce LTP in rats with neuropathic pain produced by nerve injury.

Authors+Show Affiliations

Pain Research Center, Zhongshan Medical School of Sun Yat-sen University, 510089 Guangzhou, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17084420

Citation

Liu, Yan-Ling, et al. "Tumor Necrosis Factor-alpha Induces Long-term Potentiation of C-fiber Evoked Field Potentials in Spinal Dorsal Horn in Rats With Nerve Injury: the Role of NF-kappa B, JNK and P38 MAPK." Neuropharmacology, vol. 52, no. 3, 2007, pp. 708-15.
Liu YL, Zhou LJ, Hu NW, et al. Tumor necrosis factor-alpha induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: the role of NF-kappa B, JNK and p38 MAPK. Neuropharmacology. 2007;52(3):708-15.
Liu, Y. L., Zhou, L. J., Hu, N. W., Xu, J. T., Wu, C. Y., Zhang, T., Li, Y. Y., & Liu, X. G. (2007). Tumor necrosis factor-alpha induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: the role of NF-kappa B, JNK and p38 MAPK. Neuropharmacology, 52(3), 708-15.
Liu YL, et al. Tumor Necrosis Factor-alpha Induces Long-term Potentiation of C-fiber Evoked Field Potentials in Spinal Dorsal Horn in Rats With Nerve Injury: the Role of NF-kappa B, JNK and P38 MAPK. Neuropharmacology. 2007;52(3):708-15. PubMed PMID: 17084420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tumor necrosis factor-alpha induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: the role of NF-kappa B, JNK and p38 MAPK. AU - Liu,Yan-Ling, AU - Zhou,Li-Jun, AU - Hu,Neng-Wei, AU - Xu,Ji-Tian, AU - Wu,Chang-You, AU - Zhang,Tong, AU - Li,Yong-Yong, AU - Liu,Xian-Guo, Y1 - 2006/11/02/ PY - 2006/05/15/received PY - 2006/08/21/revised PY - 2006/09/22/accepted PY - 2006/11/7/pubmed PY - 2007/5/2/medline PY - 2006/11/7/entrez SP - 708 EP - 15 JF - Neuropharmacology JO - Neuropharmacology VL - 52 IS - 3 N2 - Compelling evidence has shown that in hippocampus tumor necrosis factor alpha (TNF-alpha) at pathological concentration inhibits long-term potentiation (LTP), a synaptic model of learning and memory. In the present work we investigated the role of TNF-alpha in LTP of C-fiber evoked field potentials in spinal dorsal horn, which is relevant to pathological pain. We showed that spinal application of TNF-alpha affected neither basal synaptic transmission mediated by C-fibers nor spinal LTP of C-fiber evoked field potentials induced by tetanic stimulation in intact rats. However, in rats with neuropathic pain, produced by either lumbar 5 ventral root transection (L5 VRT) or spared nerve injury (SNI), spinal application of TNF-alpha induced LTP of C-fiber evoked field potentials. Spinal application of JNK inhibitor (SP600125) or p38 MAPK inhibitor (SB203580) did not affect the spinal LTP induced by tetanic stimulation in intact rats, but completely blocked LTP induced by TNF-alpha in L5 VRT rats. NF-kappa B (NF-kappaB) inhibitor (PDTC) also blocked LTP induced by TNF-alpha. These results suggest that TNF-alpha and its downstream molecules may have no acute effect on spinal synaptic transmission in intact animals and induce LTP in rats with neuropathic pain produced by nerve injury. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/17084420/Tumor_necrosis_factor_alpha_induces_long_term_potentiation_of_C_fiber_evoked_field_potentials_in_spinal_dorsal_horn_in_rats_with_nerve_injury:_the_role_of_NF_kappa_B_JNK_and_p38_MAPK_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(06)00333-9 DB - PRIME DP - Unbound Medicine ER -