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Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study.
Arch Biochem Biophys. 2007 Feb 15; 458(2):128-35.AB

Abstract

The xanthophylls lutein (L) and zeaxanthin (Z) form the macular pigment with the highest density in the macula lutea. We investigated Macular Pigment Optical Density (MPOD) responses to supplementation with identically formulated (Actilease) L or Z (OPTISHARP) or L+Z over 6-12 months using doses of 10 or 20mg/day. MPOD as well as blue light sensitivity in fovea and parafovea were measured monthly by heterochromatic flicker photometry. Average xanthophyll plasma concentrations, analysed monthly by HPLC, increased up to 27-fold. MPOD increased by 15% upon L or L+Z supplementation. Supplementation of Z alone produced similar pigment accumulation in fovea and parafovea, which confounded MPOD measurements. After correction for this, a 14% MPOD increase resulted for Z. Thus, during supplementation with xanthophylls, L is predominantly deposited in the fovea while Z deposition appears to cover a wider retinal area. This may be relevant to health and disease of the retina.

Authors+Show Affiliations

DSM Nutritional Products Ltd., NRD-CH, Building 203/855, Wurmisweg 576, CH-4303, Kaiseraugst, Switzerland. wolfgang.schalch@dsm.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17084803

Citation

Schalch, Wolfgang, et al. "Xanthophyll Accumulation in the Human Retina During Supplementation With Lutein or Zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) Study." Archives of Biochemistry and Biophysics, vol. 458, no. 2, 2007, pp. 128-35.
Schalch W, Cohn W, Barker FM, et al. Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study. Arch Biochem Biophys. 2007;458(2):128-35.
Schalch, W., Cohn, W., Barker, F. M., Köpcke, W., Mellerio, J., Bird, A. C., Robson, A. G., Fitzke, F. F., & van Kuijk, F. J. (2007). Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study. Archives of Biochemistry and Biophysics, 458(2), 128-35.
Schalch W, et al. Xanthophyll Accumulation in the Human Retina During Supplementation With Lutein or Zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) Study. Arch Biochem Biophys. 2007 Feb 15;458(2):128-35. PubMed PMID: 17084803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study. AU - Schalch,Wolfgang, AU - Cohn,William, AU - Barker,Felix M, AU - Köpcke,Wolfgang, AU - Mellerio,John, AU - Bird,Alan C, AU - Robson,Anthony G, AU - Fitzke,Fred F, AU - van Kuijk,Frederik J G M, Y1 - 2006/11/07/ PY - 2006/07/14/received PY - 2006/09/19/revised PY - 2006/09/20/accepted PY - 2006/11/7/pubmed PY - 2007/3/27/medline PY - 2006/11/7/entrez SP - 128 EP - 35 JF - Archives of biochemistry and biophysics JO - Arch. Biochem. Biophys. VL - 458 IS - 2 N2 - The xanthophylls lutein (L) and zeaxanthin (Z) form the macular pigment with the highest density in the macula lutea. We investigated Macular Pigment Optical Density (MPOD) responses to supplementation with identically formulated (Actilease) L or Z (OPTISHARP) or L+Z over 6-12 months using doses of 10 or 20mg/day. MPOD as well as blue light sensitivity in fovea and parafovea were measured monthly by heterochromatic flicker photometry. Average xanthophyll plasma concentrations, analysed monthly by HPLC, increased up to 27-fold. MPOD increased by 15% upon L or L+Z supplementation. Supplementation of Z alone produced similar pigment accumulation in fovea and parafovea, which confounded MPOD measurements. After correction for this, a 14% MPOD increase resulted for Z. Thus, during supplementation with xanthophylls, L is predominantly deposited in the fovea while Z deposition appears to cover a wider retinal area. This may be relevant to health and disease of the retina. SN - 0003-9861 UR - https://www.unboundmedicine.com/medline/citation/17084803/Xanthophyll_accumulation_in_the_human_retina_during_supplementation_with_lutein_or_zeaxanthin___the_LUXEA__LUtein_Xanthophyll_Eye_Accumulation__study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9861(06)00351-1 DB - PRIME DP - Unbound Medicine ER -