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Acceptability of Carraguard vaginal gel use among Thai couples.
AIDS. 2006 Nov 14; 20(17):2141-8.AIDS

Abstract

OBJECTIVES

To evaluate the acceptability of candidate microbicide Carraguard among couples participating in a safety trial.

STUDY DESIGN

A 6-month randomized, placebo-controlled trial was conducted in sexually active, low-risk couples in Thailand.

METHODS

Couples who were monogamous, HIV uninfected, and not regular condom users were enrolled. Acceptability data were collected through structured questionnaires at repeated intervals. At the closing study visit, participants were asked questions about hypothetical product characteristics and future use. Compliance with gel use was assessed by questionnaires, coital diaries, and tracking of used and unused applicators.

RESULTS

Among 55 enrolled couples, follow up and adherence with gel use were high and sustained, with 80% of women using gel in over 95% of vaginal sex acts. Because acceptability results from Carraguard and placebo arms were similar, they were combined for this analysis. Overall, 92% of women and 83% of men liked the gel somewhat or very much; 66% of women and 72% of men reported increased sexual pleasure with gel use; and 55% of women and 62% of men reported increased frequency of intercourse. Only 15% of women but 43% of men thought that gel could be used without the man knowing. Although men and women had similar views overall, concordance within couples was low, with no kappa coefficients above 0.31.

CONCLUSION

Carraguard gel use was acceptable to low-risk couples in northern Thailand. Reported associations between gel use and increased sexual pleasure and frequency suggest a potential to market microbicide products for both disease prevention and enhancement of pleasure.

Authors+Show Affiliations

National Center for HIV, Viral Hepatitis, STDs, and Tuberculosis Prevention (proposed), Centers for Disease Control and Prevention, Atlanta, USA. svw7@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17086053

Citation

Whitehead, Sara J., et al. "Acceptability of Carraguard Vaginal Gel Use Among Thai Couples." AIDS (London, England), vol. 20, no. 17, 2006, pp. 2141-8.
Whitehead SJ, Kilmarx PH, Blanchard K, et al. Acceptability of Carraguard vaginal gel use among Thai couples. AIDS. 2006;20(17):2141-8.
Whitehead, S. J., Kilmarx, P. H., Blanchard, K., Manopaiboon, C., Chaikummao, S., Friedland, B., Achalapong, J., Wankrairoj, M., Mock, P., Thanprasertsuk, S., & Tappero, J. W. (2006). Acceptability of Carraguard vaginal gel use among Thai couples. AIDS (London, England), 20(17), 2141-8.
Whitehead SJ, et al. Acceptability of Carraguard Vaginal Gel Use Among Thai Couples. AIDS. 2006 Nov 14;20(17):2141-8. PubMed PMID: 17086053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acceptability of Carraguard vaginal gel use among Thai couples. AU - Whitehead,Sara J, AU - Kilmarx,Peter H, AU - Blanchard,Kelly, AU - Manopaiboon,Chomnad, AU - Chaikummao,Supaporn, AU - Friedland,Barbara, AU - Achalapong,Jullapong, AU - Wankrairoj,Mayuree, AU - Mock,Philip, AU - Thanprasertsuk,Sombat, AU - Tappero,Jordan W, PY - 2006/11/7/pubmed PY - 2007/6/15/medline PY - 2006/11/7/entrez SP - 2141 EP - 8 JF - AIDS (London, England) JO - AIDS VL - 20 IS - 17 N2 - OBJECTIVES: To evaluate the acceptability of candidate microbicide Carraguard among couples participating in a safety trial. STUDY DESIGN: A 6-month randomized, placebo-controlled trial was conducted in sexually active, low-risk couples in Thailand. METHODS: Couples who were monogamous, HIV uninfected, and not regular condom users were enrolled. Acceptability data were collected through structured questionnaires at repeated intervals. At the closing study visit, participants were asked questions about hypothetical product characteristics and future use. Compliance with gel use was assessed by questionnaires, coital diaries, and tracking of used and unused applicators. RESULTS: Among 55 enrolled couples, follow up and adherence with gel use were high and sustained, with 80% of women using gel in over 95% of vaginal sex acts. Because acceptability results from Carraguard and placebo arms were similar, they were combined for this analysis. Overall, 92% of women and 83% of men liked the gel somewhat or very much; 66% of women and 72% of men reported increased sexual pleasure with gel use; and 55% of women and 62% of men reported increased frequency of intercourse. Only 15% of women but 43% of men thought that gel could be used without the man knowing. Although men and women had similar views overall, concordance within couples was low, with no kappa coefficients above 0.31. CONCLUSION: Carraguard gel use was acceptable to low-risk couples in northern Thailand. Reported associations between gel use and increased sexual pleasure and frequency suggest a potential to market microbicide products for both disease prevention and enhancement of pleasure. SN - 0269-9370 UR - https://www.unboundmedicine.com/medline/citation/17086053/Acceptability_of_Carraguard_vaginal_gel_use_among_Thai_couples_ L2 - https://doi.org/10.1097/QAD.0b013e32801086c9 DB - PRIME DP - Unbound Medicine ER -