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Gastric sensorimotor functions and hormone profile in normal weight, overweight, and obese people.
Gastroenterology. 2006 Dec; 131(6):1717-24.G

Abstract

BACKGROUND & AIMS

Peptide YY (PYY) levels are reported to be decreased in obesity. The relation between gastric functions, satiation, and gut hormones in obesity is incompletely understood. The aim of this study was to compare gastric volumes, emptying, maximum tolerated volumes, postchallenge symptoms, and selected gut hormones in normal, overweight, or obese healthy volunteers.

METHODS

In 73 nonbulimic normal, overweight, or obese participants weighing less than 137 kg, we measured gastric emptying of solids and liquids by scintigraphy (gastric emptying half-time [GE t(1/2)]); gastric volumes by single-photon emission computed tomography; maximum tolerated volumes and symptoms by satiation test; and plasma leptin, ghrelin, insulin, glucagon-like peptide 1, and PYY levels. Groups were compared using 1-way analysis of covariance adjusted for sex. Univariate associations among measured responses were assessed using Spearman correlations. Multiple linear regression models, adjusting for weight and sex, assessed the independent ability of gastric functions and hormones to predict satiation volume.

RESULTS

Obese and overweight subjects had significantly lower postprandial gastric volumes, higher fasting and postprandial insulin and leptin levels, and lower fasting ghrelin and lower postprandial reduction in ghrelin levels. PYY levels were not different in obese or overweight subjects compared with controls. The GE t(1/2) was correlated inversely with postprandial PYY; increased body weight was associated with faster GE t(1/2) of solids (r(s) = 0.33, P = .005) and liquids (r(s) = 0.24, P = .04). Postprandial changes in gastric volume and PYY were independent predictors of satiation (both P = .01).

CONCLUSIONS

Overweight or obesity are associated with lower postprandial gastric volumes and normal PYY levels. Gastric emptying influences postprandial PYY levels. Postprandial PYY and gastric volume independently predict satiation volume in nonbulimic people across a wide body mass index range.

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Publisher Full Text

Authors+Show Affiliations

Vazquez Roque MI
Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Camilleri M
No affiliation info available
Stephens DA
No affiliation info available
Jensen MD
No affiliation info available
Burton DD
No affiliation info available
Baxter KL
No affiliation info available
Zinsmeister AR
No affiliation info available

MeSH

AdolescentAdultAgedFemaleGastric EmptyingGastrointestinal HormonesGhrelinGlucagon-Like Peptide 1HumansInsulinLeptinMaleMiddle AgedMotor NeuronsNeurons, AfferentObesityOverweightPeptide HormonesPeptide YYRegression AnalysisSatiationStomach

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17087952

Citation

Vazquez Roque, Maria I., et al. "Gastric Sensorimotor Functions and Hormone Profile in Normal Weight, Overweight, and Obese People." Gastroenterology, vol. 131, no. 6, 2006, pp. 1717-24.
Vazquez Roque MI, Camilleri M, Stephens DA, et al. Gastric sensorimotor functions and hormone profile in normal weight, overweight, and obese people. Gastroenterology. 2006;131(6):1717-24.
Vazquez Roque, M. I., Camilleri, M., Stephens, D. A., Jensen, M. D., Burton, D. D., Baxter, K. L., & Zinsmeister, A. R. (2006). Gastric sensorimotor functions and hormone profile in normal weight, overweight, and obese people. Gastroenterology, 131(6), 1717-24.
Vazquez Roque MI, et al. Gastric Sensorimotor Functions and Hormone Profile in Normal Weight, Overweight, and Obese People. Gastroenterology. 2006;131(6):1717-24. PubMed PMID: 17087952.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric sensorimotor functions and hormone profile in normal weight, overweight, and obese people. AU - Vazquez Roque,Maria I, AU - Camilleri,Michael, AU - Stephens,Debra A, AU - Jensen,Michael D, AU - Burton,Duane D, AU - Baxter,Kari L, AU - Zinsmeister,Alan R, Y1 - 2006/10/15/ PY - 2006/06/23/received PY - 2006/08/17/accepted PY - 2006/11/8/pubmed PY - 2007/1/31/medline PY - 2006/11/8/entrez SP - 1717 EP - 24 JF - Gastroenterology JO - Gastroenterology VL - 131 IS - 6 N2 - BACKGROUND & AIMS: Peptide YY (PYY) levels are reported to be decreased in obesity. The relation between gastric functions, satiation, and gut hormones in obesity is incompletely understood. The aim of this study was to compare gastric volumes, emptying, maximum tolerated volumes, postchallenge symptoms, and selected gut hormones in normal, overweight, or obese healthy volunteers. METHODS: In 73 nonbulimic normal, overweight, or obese participants weighing less than 137 kg, we measured gastric emptying of solids and liquids by scintigraphy (gastric emptying half-time [GE t(1/2)]); gastric volumes by single-photon emission computed tomography; maximum tolerated volumes and symptoms by satiation test; and plasma leptin, ghrelin, insulin, glucagon-like peptide 1, and PYY levels. Groups were compared using 1-way analysis of covariance adjusted for sex. Univariate associations among measured responses were assessed using Spearman correlations. Multiple linear regression models, adjusting for weight and sex, assessed the independent ability of gastric functions and hormones to predict satiation volume. RESULTS: Obese and overweight subjects had significantly lower postprandial gastric volumes, higher fasting and postprandial insulin and leptin levels, and lower fasting ghrelin and lower postprandial reduction in ghrelin levels. PYY levels were not different in obese or overweight subjects compared with controls. The GE t(1/2) was correlated inversely with postprandial PYY; increased body weight was associated with faster GE t(1/2) of solids (r(s) = 0.33, P = .005) and liquids (r(s) = 0.24, P = .04). Postprandial changes in gastric volume and PYY were independent predictors of satiation (both P = .01). CONCLUSIONS: Overweight or obesity are associated with lower postprandial gastric volumes and normal PYY levels. Gastric emptying influences postprandial PYY levels. Postprandial PYY and gastric volume independently predict satiation volume in nonbulimic people across a wide body mass index range. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/17087952/Gastric_sensorimotor_functions_and_hormone_profile_in_normal_weight_overweight_and_obese_people_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(06)02259-1 DB - PRIME DP - Unbound Medicine ER -