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Neurohormonal activation in patients with systemic sclerosis-related pulmonary arterial hypertension.
Int J Cardiol. 2007 Sep 14; 121(1):135-7.IJ

Abstract

Systemic sclerosis (SSc) is a connective tissue disease, which may lead to pulmonary artery hypertension (PAH). N-terminal pro-brain natriuretic peptide (NT-proBNP) is a biologic marker for the diagnosis and treatment of congestive heart failure. The aim of our study was to investigate the potential role of the plasma NT-proBNP assay in the assessment of functional status and right heart performance in systemic sclerosis-related pulmonary hypertension (SScPAH). Systolic pulmonary artery pressure (sPAP) assessed by echocardiography, six-minute walk test (SMWT) and plasma NT-proBNP levels were recorded from 45 SSc patients. Mean value of NT-proBNP for SSc patients with PAH (n=14) was 691.7+/-325.7 fmol/L compared to 417.4+/-167.1 fmol/L for patients without PAH (n=31) (p=0.0007). In SSc patients we found a statistically significant correlation between NT-proBNP values and sPAP (r=0.32, p=0.03). Amongst SScPAH patients, NT-proBNP values were significantly correlated with sPAP (r=0.73, p=0.003) and inversely correlated with the SMWT (r=-0.60, p=0.02). These results suggest NT-proBNP as a useful additional biological tool in the evaluation and management of SScPAH patients.

Authors

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Pub Type(s)

Letter

Language

eng

PubMed ID

17088004

Citation

Dimitroulas, Theodoros, et al. "Neurohormonal Activation in Patients With Systemic Sclerosis-related Pulmonary Arterial Hypertension." International Journal of Cardiology, vol. 121, no. 1, 2007, pp. 135-7.
Dimitroulas T, Giannakoulas G, Karvounis H, et al. Neurohormonal activation in patients with systemic sclerosis-related pulmonary arterial hypertension. Int J Cardiol. 2007;121(1):135-7.
Dimitroulas, T., Giannakoulas, G., Karvounis, H., Sfetsios, T., Koliakos, G., Parcharidis, G., & Settas, L. (2007). Neurohormonal activation in patients with systemic sclerosis-related pulmonary arterial hypertension. International Journal of Cardiology, 121(1), 135-7.
Dimitroulas T, et al. Neurohormonal Activation in Patients With Systemic Sclerosis-related Pulmonary Arterial Hypertension. Int J Cardiol. 2007 Sep 14;121(1):135-7. PubMed PMID: 17088004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurohormonal activation in patients with systemic sclerosis-related pulmonary arterial hypertension. AU - Dimitroulas,Theodoros, AU - Giannakoulas,Georgios, AU - Karvounis,Haralambos, AU - Sfetsios,Tilemahos, AU - Koliakos,Georgios, AU - Parcharidis,Georgios, AU - Settas,Loucas, Y1 - 2006/11/07/ PY - 2006/08/02/received PY - 2006/08/04/accepted PY - 2006/11/8/pubmed PY - 2007/9/29/medline PY - 2006/11/8/entrez SP - 135 EP - 7 JF - International journal of cardiology JO - Int J Cardiol VL - 121 IS - 1 N2 - Systemic sclerosis (SSc) is a connective tissue disease, which may lead to pulmonary artery hypertension (PAH). N-terminal pro-brain natriuretic peptide (NT-proBNP) is a biologic marker for the diagnosis and treatment of congestive heart failure. The aim of our study was to investigate the potential role of the plasma NT-proBNP assay in the assessment of functional status and right heart performance in systemic sclerosis-related pulmonary hypertension (SScPAH). Systolic pulmonary artery pressure (sPAP) assessed by echocardiography, six-minute walk test (SMWT) and plasma NT-proBNP levels were recorded from 45 SSc patients. Mean value of NT-proBNP for SSc patients with PAH (n=14) was 691.7+/-325.7 fmol/L compared to 417.4+/-167.1 fmol/L for patients without PAH (n=31) (p=0.0007). In SSc patients we found a statistically significant correlation between NT-proBNP values and sPAP (r=0.32, p=0.03). Amongst SScPAH patients, NT-proBNP values were significantly correlated with sPAP (r=0.73, p=0.003) and inversely correlated with the SMWT (r=-0.60, p=0.02). These results suggest NT-proBNP as a useful additional biological tool in the evaluation and management of SScPAH patients. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/17088004/Neurohormonal_activation_in_patients_with_systemic_sclerosis_related_pulmonary_arterial_hypertension_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(06)01152-1 DB - PRIME DP - Unbound Medicine ER -