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The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes.
J Endocrinol. 2006 Nov; 191(2):399-405.JE

Abstract

The mechanisms underlying menopausal hot flushes are poorly understood, although it is generally assumed they result from disturbances of thermoregulatory centres in the hypothalamus. 8-Prenylnaringenin (8-PN) has been identified as a potent phytoestrogen in hops (Humulus lupulus) and there are claims that hop-containing preparations can reduce hot flushes. We have investigated the site of action of 8-PN in a rat model of menopausal hot flushes, in which the tail skin temperature (TST) is increased after oestrogen withdrawal induced by ovariectomy. Daily s.c. administration of either 17beta-oestradiol (E2; 4 microg/kg) or 8-PN (400 microg/kg) significantly reduced the elevated TST after 2 days of treatment. Subcutaneous co-administration of either E2 or 8-PN with the oestrogen receptor (ER) antagonist, ICI 182,780 (200 microg/kg), which is thought not to cross the blood-brain barrier, completely blocked the effect of E2 and 8-PN on TST. The ERalpha- and ERbeta-specific agonists, 4,4',4''-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (100 microg/kg) and 2,3-bis(4-hydroxyphenyl)-propionitrile (60 microg/kg) respectively, both significantly reversed the raised TST in ovariectomised rats. These observations suggest that the regulation of the vasomotor response by oestrogens and phytoestrogens is mediated, at least in part, by peripheral mechanisms involving both ERalpha and ERbeta.

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Authors+Show Affiliations

Bowe J
Division of Reproduction and Endocrinology, King's College London, 2.36D New Hunt's House, Guy's Campus, London SE1 1UL, UK.
Li XF
No affiliation info available
Kinsey-Jones J
No affiliation info available
Heyerick A
No affiliation info available
Brain S
No affiliation info available
Milligan S
No affiliation info available
O'Byrne K
No affiliation info available

MeSH

AnimalsBeerEstradiolEstrogen AntagonistsEstrogen Receptor alphaEstrogen Receptor betaFemaleFlavanonesFulvestrantHot FlashesHumulusModels, AnimalNitrilesOvariectomyPhenolsPhytotherapyPyrazolesRatsRats, WistarSkin TemperatureTail

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17088409

Citation

Bowe, James, et al. "The Hop Phytoestrogen, 8-prenylnaringenin, Reverses the Ovariectomy-induced Rise in Skin Temperature in an Animal Model of Menopausal Hot Flushes." The Journal of Endocrinology, vol. 191, no. 2, 2006, pp. 399-405.
Bowe J, Li XF, Kinsey-Jones J, et al. The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes. J Endocrinol. 2006;191(2):399-405.
Bowe, J., Li, X. F., Kinsey-Jones, J., Heyerick, A., Brain, S., Milligan, S., & O'Byrne, K. (2006). The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes. The Journal of Endocrinology, 191(2), 399-405.
Bowe J, et al. The Hop Phytoestrogen, 8-prenylnaringenin, Reverses the Ovariectomy-induced Rise in Skin Temperature in an Animal Model of Menopausal Hot Flushes. J Endocrinol. 2006;191(2):399-405. PubMed PMID: 17088409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes. AU - Bowe,James, AU - Li,Xiao Feng, AU - Kinsey-Jones,James, AU - Heyerick,Arne, AU - Brain,Susan, AU - Milligan,Stuart, AU - O'Byrne,Kevin, PY - 2006/11/8/pubmed PY - 2007/3/6/medline PY - 2006/11/8/entrez SP - 399 EP - 405 JF - The Journal of endocrinology JO - J Endocrinol VL - 191 IS - 2 N2 - The mechanisms underlying menopausal hot flushes are poorly understood, although it is generally assumed they result from disturbances of thermoregulatory centres in the hypothalamus. 8-Prenylnaringenin (8-PN) has been identified as a potent phytoestrogen in hops (Humulus lupulus) and there are claims that hop-containing preparations can reduce hot flushes. We have investigated the site of action of 8-PN in a rat model of menopausal hot flushes, in which the tail skin temperature (TST) is increased after oestrogen withdrawal induced by ovariectomy. Daily s.c. administration of either 17beta-oestradiol (E2; 4 microg/kg) or 8-PN (400 microg/kg) significantly reduced the elevated TST after 2 days of treatment. Subcutaneous co-administration of either E2 or 8-PN with the oestrogen receptor (ER) antagonist, ICI 182,780 (200 microg/kg), which is thought not to cross the blood-brain barrier, completely blocked the effect of E2 and 8-PN on TST. The ERalpha- and ERbeta-specific agonists, 4,4',4''-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (100 microg/kg) and 2,3-bis(4-hydroxyphenyl)-propionitrile (60 microg/kg) respectively, both significantly reversed the raised TST in ovariectomised rats. These observations suggest that the regulation of the vasomotor response by oestrogens and phytoestrogens is mediated, at least in part, by peripheral mechanisms involving both ERalpha and ERbeta. SN - 0022-0795 UR - https://www.unboundmedicine.com/medline/citation/17088409/The_hop_phytoestrogen_8_prenylnaringenin_reverses_the_ovariectomy_induced_rise_in_skin_temperature_in_an_animal_model_of_menopausal_hot_flushes_ L2 - https://joe.bioscientifica.com/doi/10.1677/joe.1.06919 DB - PRIME DP - Unbound Medicine ER -