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Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy.
Acta Neuropathol. 2007 Jan; 113(1):81-6.AN

Abstract

Decreased cardiac uptake of meta-iodobenzylguanidine (MIBG) on [(123)I] MIBG myocardial scintigraphy, a sensitive biological marker for Parkinson's disease (PD), is related to cardiac sympathetic denervation in patients with PD. A slight decrease in cardiac uptake of MIBG has also been reported in some patients with multiple system atrophy (MSA). However, the pathophysiological mechanism accounting for the slight decrease in MIBG uptake in MSA remains to be elucidated. For confirmation, we examined cardiac tissue and sympathetic ganglia from patients with MSA. We immunohistochemically examined each specimen of 15 patients with MSA together with 10 control subjects using antibodies against tyrosine hydroxylase (TH) and neurofilament (NF). The number of TH-immunoreactive nerve fibers in the epicardium was preserved in 8 of 15 patients with MSA as well as in 10 control subjects. The number of TH-immunoreactive, but not of NF-immunoreactive nerve fibers in the epicardium was mildly or moderately decreased in six patients with MSA, of whom four showed a decrease of TH immunoreactivity in the neuronal somata in the sympathetic ganglia. Moreover, TH- and NF-immunoreactive nerve fibers almost entirely disappeared in the heart of one patient with MSA, in whom Lewy body pathology was present in the sympathetic ganglia. These findings suggest that mild degeneration of the cardiac sympathetic nerve can occur in MSA which is closely related to the pathological change of neurons in the sympathetic ganglia, accounting for the slight decrease in cardiac uptake of MIBG. Moreover, concurrent Lewy body pathology in the sympathetic ganglia might accelerate cardiac sympathetic denervation even in MSA.

Authors+Show Affiliations

Department of Neurology, Kanto Central Hospital, 6-25-1 Kami-Yoga, Setagaya-ku, Tokyo, 158-8531, Japan. orimo@kanto-ctr-hsp.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17089131

Citation

Orimo, Satoshi, et al. "Degeneration of Cardiac Sympathetic Nerve Can Occur in Multiple System Atrophy." Acta Neuropathologica, vol. 113, no. 1, 2007, pp. 81-6.
Orimo S, Kanazawa T, Nakamura A, et al. Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy. Acta Neuropathol. 2007;113(1):81-6.
Orimo, S., Kanazawa, T., Nakamura, A., Uchihara, T., Mori, F., Kakita, A., Wakabayashi, K., & Takahashi, H. (2007). Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy. Acta Neuropathologica, 113(1), 81-6.
Orimo S, et al. Degeneration of Cardiac Sympathetic Nerve Can Occur in Multiple System Atrophy. Acta Neuropathol. 2007;113(1):81-6. PubMed PMID: 17089131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy. AU - Orimo,Satoshi, AU - Kanazawa,Toshiro, AU - Nakamura,Ayako, AU - Uchihara,Toshiki, AU - Mori,Fumiaki, AU - Kakita,Akiyoshi, AU - Wakabayashi,Koichi, AU - Takahashi,Hitoshi, Y1 - 2006/11/07/ PY - 2006/09/21/received PY - 2006/10/13/accepted PY - 2006/10/13/revised PY - 2006/11/8/pubmed PY - 2007/10/30/medline PY - 2006/11/8/entrez SP - 81 EP - 6 JF - Acta neuropathologica JO - Acta Neuropathol VL - 113 IS - 1 N2 - Decreased cardiac uptake of meta-iodobenzylguanidine (MIBG) on [(123)I] MIBG myocardial scintigraphy, a sensitive biological marker for Parkinson's disease (PD), is related to cardiac sympathetic denervation in patients with PD. A slight decrease in cardiac uptake of MIBG has also been reported in some patients with multiple system atrophy (MSA). However, the pathophysiological mechanism accounting for the slight decrease in MIBG uptake in MSA remains to be elucidated. For confirmation, we examined cardiac tissue and sympathetic ganglia from patients with MSA. We immunohistochemically examined each specimen of 15 patients with MSA together with 10 control subjects using antibodies against tyrosine hydroxylase (TH) and neurofilament (NF). The number of TH-immunoreactive nerve fibers in the epicardium was preserved in 8 of 15 patients with MSA as well as in 10 control subjects. The number of TH-immunoreactive, but not of NF-immunoreactive nerve fibers in the epicardium was mildly or moderately decreased in six patients with MSA, of whom four showed a decrease of TH immunoreactivity in the neuronal somata in the sympathetic ganglia. Moreover, TH- and NF-immunoreactive nerve fibers almost entirely disappeared in the heart of one patient with MSA, in whom Lewy body pathology was present in the sympathetic ganglia. These findings suggest that mild degeneration of the cardiac sympathetic nerve can occur in MSA which is closely related to the pathological change of neurons in the sympathetic ganglia, accounting for the slight decrease in cardiac uptake of MIBG. Moreover, concurrent Lewy body pathology in the sympathetic ganglia might accelerate cardiac sympathetic denervation even in MSA. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/17089131/Degeneration_of_cardiac_sympathetic_nerve_can_occur_in_multiple_system_atrophy_ L2 - https://dx.doi.org/10.1007/s00401-006-0160-y DB - PRIME DP - Unbound Medicine ER -