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Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease.
Acta Neuropathol 2007; 113(2):107-17AN

Abstract

Neurofibrillary tangle predominant dementia (NFTPD) is a subset of late onset dementia, clinically different from traditional "plaque and tangle" Alzheimer disease (AD): later onset, shorter duration, less severe cognitive impairment, and almost absence of ApoE epsilon4. Neuropathology reveals abundant allocortical neurofibrillary pathology with no or few isocortical tau lesions, absence of neuritic plaques, absence or scarcity of amyloid deposits, but neurofibrillary changes comprising both 3 and 4 repeat (3R and 4R) tau immunohistochemistry are not significantly different from those in classical AD. Comparing 51 autopsy cases of NFTPD with 244 classical AD subjects, the nosology of NFTPD and its differences from AD are discussed.

Authors+Show Affiliations

Institute of Clinical Neurobiology, 18, Kenyongasse, 1070, Vienna, Austria. kurt.jellinger@univie.ac.atNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17089134

Citation

Jellinger, K A., and J Attems. "Neurofibrillary Tangle-predominant Dementia: Comparison With Classical Alzheimer Disease." Acta Neuropathologica, vol. 113, no. 2, 2007, pp. 107-17.
Jellinger KA, Attems J. Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease. Acta Neuropathol. 2007;113(2):107-17.
Jellinger, K. A., & Attems, J. (2007). Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease. Acta Neuropathologica, 113(2), pp. 107-17.
Jellinger KA, Attems J. Neurofibrillary Tangle-predominant Dementia: Comparison With Classical Alzheimer Disease. Acta Neuropathol. 2007;113(2):107-17. PubMed PMID: 17089134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease. AU - Jellinger,K A, AU - Attems,J, Y1 - 2006/11/07/ PY - 2006/09/12/received PY - 2006/10/04/accepted PY - 2006/10/04/revised PY - 2006/11/8/pubmed PY - 2007/6/15/medline PY - 2006/11/8/entrez SP - 107 EP - 17 JF - Acta neuropathologica JO - Acta Neuropathol. VL - 113 IS - 2 N2 - Neurofibrillary tangle predominant dementia (NFTPD) is a subset of late onset dementia, clinically different from traditional "plaque and tangle" Alzheimer disease (AD): later onset, shorter duration, less severe cognitive impairment, and almost absence of ApoE epsilon4. Neuropathology reveals abundant allocortical neurofibrillary pathology with no or few isocortical tau lesions, absence of neuritic plaques, absence or scarcity of amyloid deposits, but neurofibrillary changes comprising both 3 and 4 repeat (3R and 4R) tau immunohistochemistry are not significantly different from those in classical AD. Comparing 51 autopsy cases of NFTPD with 244 classical AD subjects, the nosology of NFTPD and its differences from AD are discussed. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/17089134/Neurofibrillary_tangle_predominant_dementia:_comparison_with_classical_Alzheimer_disease_ L2 - https://dx.doi.org/10.1007/s00401-006-0156-7 DB - PRIME DP - Unbound Medicine ER -