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Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease.
Mov Disord. 2007 Jan; 22(1):141-5.MD

Abstract

We studied the relationship between two screening cognitive measures and off motor Unified Parkinson's Disease Rating Scale (UPDRS) scores in 108 Parkinson's disease patients. Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized beta = -0.57, t(104) = -3.31, P < 0.01, and Dementia Rating Scale-2 (DRS-2), normalized beta = -0.45, t(104) = -2.55, P < 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized beta = -0.39, t(105) = -3.19, P < 0.01, and DRS-2 scores, normalized beta = -0.40, t(106) = -3.28, P < 0.01. When including left-sided and right-sided subscores, only the right-sided symptoms predicted DRS-2 scores, normalized beta = -0.28, t(105) = -2.45, P < 0.05, and showed a trend toward predicting MMSE scores, normalized beta = -0.22, t(105) = -1.95, P = 0.054. We therefore found that right-sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were the best predictors of cognitive function.

Authors+Show Affiliations

Department of Neurology, University of Florida College of Medicine, Gainesville, Florida 32610, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17089386

Citation

Williams, Lindsy N., et al. "Laterality, Region, and Type of Motor Dysfunction Correlate With Cognitive Impairment in Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 22, no. 1, 2007, pp. 141-5.
Williams LN, Seignourel P, Crucian GP, et al. Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease. Mov Disord. 2007;22(1):141-5.
Williams, L. N., Seignourel, P., Crucian, G. P., Okun, M. S., Rodriguez, R. L., Skidmore, F. M., Foster, P. S., Jacobson, C. E., Romrell, J., Bowers, D., & Fernandez, H. H. (2007). Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 22(1), 141-5.
Williams LN, et al. Laterality, Region, and Type of Motor Dysfunction Correlate With Cognitive Impairment in Parkinson's Disease. Mov Disord. 2007;22(1):141-5. PubMed PMID: 17089386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease. AU - Williams,Lindsy N, AU - Seignourel,Paul, AU - Crucian,Gregory P, AU - Okun,Michael S, AU - Rodriguez,Ramon L, AU - Skidmore,Frank M, AU - Foster,Paul S, AU - Jacobson,Charles E,4th AU - Romrell,Janet, AU - Bowers,Dawn, AU - Fernandez,Hubert H, PY - 2006/11/8/pubmed PY - 2007/4/6/medline PY - 2006/11/8/entrez SP - 141 EP - 5 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 22 IS - 1 N2 - We studied the relationship between two screening cognitive measures and off motor Unified Parkinson's Disease Rating Scale (UPDRS) scores in 108 Parkinson's disease patients. Multiple regressions were conducted to examine the UPDRS subscores' unique contributions to cognitive function. When including bradykinesia, rigidity, and postural/gait instability subscores, only bradykinesia predicted Mini Mental Status Examination (MMSE), normalized beta = -0.57, t(104) = -3.31, P < 0.01, and Dementia Rating Scale-2 (DRS-2), normalized beta = -0.45, t(104) = -2.55, P < 0.05. Tremor was not included in the regression analyses because it did not correlate with cognitive function. When including axial and appendicular subscores, only the axial subscore predicted MMSE, normalized beta = -0.39, t(105) = -3.19, P < 0.01, and DRS-2 scores, normalized beta = -0.40, t(106) = -3.28, P < 0.01. When including left-sided and right-sided subscores, only the right-sided symptoms predicted DRS-2 scores, normalized beta = -0.28, t(105) = -2.45, P < 0.05, and showed a trend toward predicting MMSE scores, normalized beta = -0.22, t(105) = -1.95, P = 0.054. We therefore found that right-sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were the best predictors of cognitive function. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/17089386/Laterality_region_and_type_of_motor_dysfunction_correlate_with_cognitive_impairment_in_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.21220 DB - PRIME DP - Unbound Medicine ER -