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Follow-up bronchoalveolar lavage in AIDS patients with Pneumocystis carinii pneumonia. Pneumocystis carinii burden predicts early relapse.
Am Rev Respir Dis. 1991 May; 143(5 Pt 1):1067-71.AR

Abstract

We performed an analysis of the value of repeat bronchoalveolar lavage (BAL) at 21 days to identify patients at risk for early relapse with Pneumocystis carinii pneumonia. Patients with P. carinii pneumonia and the acquired immunodeficiency syndrome (AIDS) were asked to participate in this study. All patients had P. carinii identified on methenamine silver stain of BAL fluid. BAL fluid was also stained with a modified Wright-Giemsa technique. The Wright-Giemsa stain was done to determine the cell differential count, and the number of P. carinii clusters associated with 500 nucleated cells was used as an estimate of P. carinii burden in the BAL. Initial and follow-up lavage was performed in 56 patients. Patients were classified based on their clinical response to anti-P. carinii therapy at 21 days. Nonresponders were patients with persistent or worsening symptoms. Responders were patients who improved and had therapy discontinued. Responders were further classified as responders with relapse if P. carinii pneumonia recurred within 6 months of the initial episode or responders without relapse if they remained disease free during the follow-up period. Responders without relapse reduced P. carinii cluster counts more than 50% in 24 of 25 cases. In responders with relapse P. carinii cluster counts were unchanged. The responders as a group had a significant decrease in the percentage of neutrophils in the BAL, with only 2 of 32 still having increased neutrophils in the follow-up lavage compared to 17 of 24 nonresponders (p less than 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Medicine, University of Cincinnati Medical Center, Ohio.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1708950

Citation

Colangelo, G, et al. "Follow-up Bronchoalveolar Lavage in AIDS Patients With Pneumocystis Carinii Pneumonia. Pneumocystis Carinii Burden Predicts Early Relapse." The American Review of Respiratory Disease, vol. 143, no. 5 Pt 1, 1991, pp. 1067-71.
Colangelo G, Baughman RP, Dohn MN, et al. Follow-up bronchoalveolar lavage in AIDS patients with Pneumocystis carinii pneumonia. Pneumocystis carinii burden predicts early relapse. Am Rev Respir Dis. 1991;143(5 Pt 1):1067-71.
Colangelo, G., Baughman, R. P., Dohn, M. N., & Frame, P. T. (1991). Follow-up bronchoalveolar lavage in AIDS patients with Pneumocystis carinii pneumonia. Pneumocystis carinii burden predicts early relapse. The American Review of Respiratory Disease, 143(5 Pt 1), 1067-71.
Colangelo G, et al. Follow-up Bronchoalveolar Lavage in AIDS Patients With Pneumocystis Carinii Pneumonia. Pneumocystis Carinii Burden Predicts Early Relapse. Am Rev Respir Dis. 1991;143(5 Pt 1):1067-71. PubMed PMID: 1708950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Follow-up bronchoalveolar lavage in AIDS patients with Pneumocystis carinii pneumonia. Pneumocystis carinii burden predicts early relapse. AU - Colangelo,G, AU - Baughman,R P, AU - Dohn,M N, AU - Frame,P T, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez SP - 1067 EP - 71 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 143 IS - 5 Pt 1 N2 - We performed an analysis of the value of repeat bronchoalveolar lavage (BAL) at 21 days to identify patients at risk for early relapse with Pneumocystis carinii pneumonia. Patients with P. carinii pneumonia and the acquired immunodeficiency syndrome (AIDS) were asked to participate in this study. All patients had P. carinii identified on methenamine silver stain of BAL fluid. BAL fluid was also stained with a modified Wright-Giemsa technique. The Wright-Giemsa stain was done to determine the cell differential count, and the number of P. carinii clusters associated with 500 nucleated cells was used as an estimate of P. carinii burden in the BAL. Initial and follow-up lavage was performed in 56 patients. Patients were classified based on their clinical response to anti-P. carinii therapy at 21 days. Nonresponders were patients with persistent or worsening symptoms. Responders were patients who improved and had therapy discontinued. Responders were further classified as responders with relapse if P. carinii pneumonia recurred within 6 months of the initial episode or responders without relapse if they remained disease free during the follow-up period. Responders without relapse reduced P. carinii cluster counts more than 50% in 24 of 25 cases. In responders with relapse P. carinii cluster counts were unchanged. The responders as a group had a significant decrease in the percentage of neutrophils in the BAL, with only 2 of 32 still having increased neutrophils in the follow-up lavage compared to 17 of 24 nonresponders (p less than 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/1708950/Follow_up_bronchoalveolar_lavage_in_AIDS_patients_with_Pneumocystis_carinii_pneumonia__Pneumocystis_carinii_burden_predicts_early_relapse_ L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/143.5_Pt_1.1067?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -