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A comparison of oral midazolam and nitrous oxide sedation for dental extractions in children.
Anaesthesia. 2006 Dec; 61(12):1138-44.A

Abstract

The aim of the study was to compare oral midazolam and inhaled nitrous oxide as sedative agents during the management of children aged 5-10 years presenting for extraction of primary teeth under local anaesthetic. Subjects required two visits for the extraction of four primary teeth, one in each quadrant of the mouth, and were randomly allocated to be given nitrous oxide 30% in oxygen or oral midazolam 0.3 mg.kg(-1) at the first visit, the other technique being used at the second visit. Vital signs, sedation levels and behavioural scores were recorded, and postoperative recall and satisfaction were reported by the patients. Thirty-five children, with a mean [range] age of 7.4 [5-10] years, completed the treatment. The mean dose of oral midazolam given was 8.6 [3.3-16.5] mg. The mean times taken to achieve the maximum level of sedation for midazolam and nitrous oxide sedation were 15.9 [2-30] min and 6.8 [2-10] min, respectively. Physiological parameters remained within acceptable clinical limits for both types of sedation. Oral midazolam was considered acceptable by 59% and was preferred by 36%. Oral midazolam sedation in 5 to 10-year-old children was shown to be as safe and effective as nitrous oxide in oxygen sedation for extraction of primary teeth but would not be the method of choice for all patients.

Authors+Show Affiliations

Department of Sedation, Newcastle School of Dental Sciences and Dental Hospital, Newcastle upon Tyne, UK. katherine.wilson@ncl.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17090232

Citation

Wilson, K E., et al. "A Comparison of Oral Midazolam and Nitrous Oxide Sedation for Dental Extractions in Children." Anaesthesia, vol. 61, no. 12, 2006, pp. 1138-44.
Wilson KE, Girdler NM, Welbury RR. A comparison of oral midazolam and nitrous oxide sedation for dental extractions in children. Anaesthesia. 2006;61(12):1138-44.
Wilson, K. E., Girdler, N. M., & Welbury, R. R. (2006). A comparison of oral midazolam and nitrous oxide sedation for dental extractions in children. Anaesthesia, 61(12), 1138-44.
Wilson KE, Girdler NM, Welbury RR. A Comparison of Oral Midazolam and Nitrous Oxide Sedation for Dental Extractions in Children. Anaesthesia. 2006;61(12):1138-44. PubMed PMID: 17090232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of oral midazolam and nitrous oxide sedation for dental extractions in children. AU - Wilson,K E, AU - Girdler,N M, AU - Welbury,R R, PY - 2006/11/9/pubmed PY - 2007/2/23/medline PY - 2006/11/9/entrez SP - 1138 EP - 44 JF - Anaesthesia JO - Anaesthesia VL - 61 IS - 12 N2 - The aim of the study was to compare oral midazolam and inhaled nitrous oxide as sedative agents during the management of children aged 5-10 years presenting for extraction of primary teeth under local anaesthetic. Subjects required two visits for the extraction of four primary teeth, one in each quadrant of the mouth, and were randomly allocated to be given nitrous oxide 30% in oxygen or oral midazolam 0.3 mg.kg(-1) at the first visit, the other technique being used at the second visit. Vital signs, sedation levels and behavioural scores were recorded, and postoperative recall and satisfaction were reported by the patients. Thirty-five children, with a mean [range] age of 7.4 [5-10] years, completed the treatment. The mean dose of oral midazolam given was 8.6 [3.3-16.5] mg. The mean times taken to achieve the maximum level of sedation for midazolam and nitrous oxide sedation were 15.9 [2-30] min and 6.8 [2-10] min, respectively. Physiological parameters remained within acceptable clinical limits for both types of sedation. Oral midazolam was considered acceptable by 59% and was preferred by 36%. Oral midazolam sedation in 5 to 10-year-old children was shown to be as safe and effective as nitrous oxide in oxygen sedation for extraction of primary teeth but would not be the method of choice for all patients. SN - 0003-2409 UR - https://www.unboundmedicine.com/medline/citation/17090232/A_comparison_of_oral_midazolam_and_nitrous_oxide_sedation_for_dental_extractions_in_children_ L2 - https://doi.org/10.1111/j.1365-2044.2006.04835.x DB - PRIME DP - Unbound Medicine ER -