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Diabetes, gender, and left ventricular structure in African-Americans: the atherosclerosis risk in communities study.
Cardiovasc Ultrasound. 2006 Nov 08; 4:43.CU

Abstract

BACKGROUND

Cardiovascular risk associated with diabetes may be partially attributed to left ventricular structural abnormalities. However, the relations between left ventricular structure and diabetes have not been extensively studied in African-Americans.

METHODS

We studied 514 male and 965 female African-Americans 51 to 70 years old, in whom echocardiographic left ventricular mass measurements were collected for the ARIC Study. In these, we investigated the independent association of diabetes with left ventricular structural abnormalities.

RESULTS

Diabetes, hypertension and obesity prevalences were 22%, 57% and 45%, respectively. Unindexed left ventricular mass was higher with diabetes in both men (238.3 +/- 79.4 g vs. 213.7 +/- 58.6 g; p < 0.001) and women (206.4 +/- 61.5 g vs. 176.9 +/- 50.1 g; p < 0.001), respectively. Prevalence of height-indexed left ventricular hypertrophy was higher in women while increased relative wall thickness was similar in men and women. Those with diabetes had higher prevalences of height-indexed left ventricular hypertrophy (52% vs. 32%; p < 0.001), and of increased relative wall thickness (73% vs. 64%; p = 0.002). Gender-adjusted associations of diabetes with left ventricular hypertrophy (OR = 2.29 95% CI:1.79-2.94) were attenuated after multiple adjustments in logistic regression (OR = 1.50 95% CI:1.12-2.00). Diabetes was associated with higher left ventricle diameter (OR = 2.13 95% CI:1.28-3.53) only in men and with higher wall thickness (OR = 1.89 95% CI:1.34-2.66) only in women. Attenuations in diabetes associations were frequently seen after adjustment for obesity indices.

CONCLUSION

In African-Americans, diabetes is associated with left ventricular hypertrophy and, with different patterns of left ventricular structural abnormalities between genders. Attenuation seen in adjusted associations suggests that the higher frequency of structural abnormalities seen in diabetes may be due to factors other than hyperglycemia.

Authors+Show Affiliations

Graduate Studies Program in Cardiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. mfoppa@cpovo.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17092348

Citation

Foppa, Murilo, et al. "Diabetes, Gender, and Left Ventricular Structure in African-Americans: the Atherosclerosis Risk in Communities Study." Cardiovascular Ultrasound, vol. 4, 2006, p. 43.
Foppa M, Duncan BB, Arnett DK, et al. Diabetes, gender, and left ventricular structure in African-Americans: the atherosclerosis risk in communities study. Cardiovasc Ultrasound. 2006;4:43.
Foppa, M., Duncan, B. B., Arnett, D. K., Benjamin, E. J., Liebson, P. R., Manolio, T. A., & Skelton, T. N. (2006). Diabetes, gender, and left ventricular structure in African-Americans: the atherosclerosis risk in communities study. Cardiovascular Ultrasound, 4, 43.
Foppa M, et al. Diabetes, Gender, and Left Ventricular Structure in African-Americans: the Atherosclerosis Risk in Communities Study. Cardiovasc Ultrasound. 2006 Nov 8;4:43. PubMed PMID: 17092348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes, gender, and left ventricular structure in African-Americans: the atherosclerosis risk in communities study. AU - Foppa,Murilo, AU - Duncan,Bruce B, AU - Arnett,Donna K, AU - Benjamin,Emelia J, AU - Liebson,Philip R, AU - Manolio,Teri A, AU - Skelton,Thomas N, Y1 - 2006/11/08/ PY - 2006/09/14/received PY - 2006/11/08/accepted PY - 2006/11/10/pubmed PY - 2007/1/17/medline PY - 2006/11/10/entrez SP - 43 EP - 43 JF - Cardiovascular ultrasound JO - Cardiovasc Ultrasound VL - 4 N2 - BACKGROUND: Cardiovascular risk associated with diabetes may be partially attributed to left ventricular structural abnormalities. However, the relations between left ventricular structure and diabetes have not been extensively studied in African-Americans. METHODS: We studied 514 male and 965 female African-Americans 51 to 70 years old, in whom echocardiographic left ventricular mass measurements were collected for the ARIC Study. In these, we investigated the independent association of diabetes with left ventricular structural abnormalities. RESULTS: Diabetes, hypertension and obesity prevalences were 22%, 57% and 45%, respectively. Unindexed left ventricular mass was higher with diabetes in both men (238.3 +/- 79.4 g vs. 213.7 +/- 58.6 g; p < 0.001) and women (206.4 +/- 61.5 g vs. 176.9 +/- 50.1 g; p < 0.001), respectively. Prevalence of height-indexed left ventricular hypertrophy was higher in women while increased relative wall thickness was similar in men and women. Those with diabetes had higher prevalences of height-indexed left ventricular hypertrophy (52% vs. 32%; p < 0.001), and of increased relative wall thickness (73% vs. 64%; p = 0.002). Gender-adjusted associations of diabetes with left ventricular hypertrophy (OR = 2.29 95% CI:1.79-2.94) were attenuated after multiple adjustments in logistic regression (OR = 1.50 95% CI:1.12-2.00). Diabetes was associated with higher left ventricle diameter (OR = 2.13 95% CI:1.28-3.53) only in men and with higher wall thickness (OR = 1.89 95% CI:1.34-2.66) only in women. Attenuations in diabetes associations were frequently seen after adjustment for obesity indices. CONCLUSION: In African-Americans, diabetes is associated with left ventricular hypertrophy and, with different patterns of left ventricular structural abnormalities between genders. Attenuation seen in adjusted associations suggests that the higher frequency of structural abnormalities seen in diabetes may be due to factors other than hyperglycemia. SN - 1476-7120 UR - https://www.unboundmedicine.com/medline/citation/17092348/Diabetes_gender_and_left_ventricular_structure_in_African_Americans:_the_atherosclerosis_risk_in_communities_study_ L2 - https://cardiovascularultrasound.biomedcentral.com/articles/10.1186/1476-7120-4-43 DB - PRIME DP - Unbound Medicine ER -