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Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG).
Phytomedicine. 2007 Aug; 14(7-8):551-5.P

Abstract

Green tea is a popular worldwide beverage, and its potential beneficial effects such as anti-cancer and anti-oxidant properties are believed to be mediated by epigallocatechin-3-gallate (EGCG), a major constituent of polyphenols. Recently, it was reported that EGCG might be useful in the prevention or treatment of androgenetic alopecia by selectively inhibiting 5alpha-reductase activity. However, no report has been issued to date on the effect of EGCG on human hair growth. This study was undertaken to measure the effect of EGCG on hair growth in vitro and to investigate its effect on human dermal papilla cells (DPCs) in vivo and in vitro. EGCG promoted hair growth in hair follicles ex vivo culture and the proliferation of cultured DPCs. The growth stimulation of DPCs by EGCG in vitro may be mediated through the upregulations of phosphorylated Erk and Akt and by an increase in the ratio of Bcl-2/Bax ratio. Similar results were also obtained in in vivo dermal papillae of human scalps. Thus, we suggest that EGCG stimulates human hair growth through these dual proliferative and anti-apoptotic effects on DPCs.

Authors+Show Affiliations

Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging and Hair Research, Seoul National University Hospital, Institute of Dermatological Science, Seoul National University, 110-744 Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17092697

Citation

Kwon, O S., et al. "Human Hair Growth Enhancement in Vitro By Green Tea Epigallocatechin-3-gallate (EGCG)." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 14, no. 7-8, 2007, pp. 551-5.
Kwon OS, Han JH, Yoo HG, et al. Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG). Phytomedicine. 2007;14(7-8):551-5.
Kwon, O. S., Han, J. H., Yoo, H. G., Chung, J. H., Cho, K. H., Eun, H. C., & Kim, K. H. (2007). Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG). Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 14(7-8), 551-5.
Kwon OS, et al. Human Hair Growth Enhancement in Vitro By Green Tea Epigallocatechin-3-gallate (EGCG). Phytomedicine. 2007;14(7-8):551-5. PubMed PMID: 17092697.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG). AU - Kwon,O S, AU - Han,J H, AU - Yoo,H G, AU - Chung,J H, AU - Cho,K H, AU - Eun,H C, AU - Kim,K H, Y1 - 2006/11/07/ PY - 2006/11/10/pubmed PY - 2007/9/26/medline PY - 2006/11/10/entrez SP - 551 EP - 5 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 14 IS - 7-8 N2 - Green tea is a popular worldwide beverage, and its potential beneficial effects such as anti-cancer and anti-oxidant properties are believed to be mediated by epigallocatechin-3-gallate (EGCG), a major constituent of polyphenols. Recently, it was reported that EGCG might be useful in the prevention or treatment of androgenetic alopecia by selectively inhibiting 5alpha-reductase activity. However, no report has been issued to date on the effect of EGCG on human hair growth. This study was undertaken to measure the effect of EGCG on hair growth in vitro and to investigate its effect on human dermal papilla cells (DPCs) in vivo and in vitro. EGCG promoted hair growth in hair follicles ex vivo culture and the proliferation of cultured DPCs. The growth stimulation of DPCs by EGCG in vitro may be mediated through the upregulations of phosphorylated Erk and Akt and by an increase in the ratio of Bcl-2/Bax ratio. Similar results were also obtained in in vivo dermal papillae of human scalps. Thus, we suggest that EGCG stimulates human hair growth through these dual proliferative and anti-apoptotic effects on DPCs. SN - 0944-7113 UR - https://www.unboundmedicine.com/medline/citation/17092697/Human_hair_growth_enhancement_in_vitro_by_green_tea_epigallocatechin_3_gallate__EGCG__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(06)00138-3 DB - PRIME DP - Unbound Medicine ER -