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Antioxidant and apoptosis-inducing activities of ellagic acid.
Anticancer Res. 2006 Sep-Oct; 26(5A):3601-6.AR

Abstract

BACKGROUND

Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied.

MATERIALS AND METHODS

DPPH radical scavenging and lipid peroxidation inhibitory activities were observed. Activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were measured in ellagic acid-treated V79-4 cells. For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured.

RESULTS

Ellagic acid showed high DPPH radical scavenging and lipid peroxidation inhibition activities. SOD, CAT and GPX activities were significantly increased in ellagic acid-treated V79-4 cells. Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. Bax expression was induced and caspase-3 was activated by ellagic acid treatment.

CONCLUSION

Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3.

Authors+Show Affiliations

Department of Biochemistry, College of Dentistry, Kyung Hee University, Seoul 130-701, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17094489

Citation

Han, Dong Hoon, et al. "Antioxidant and Apoptosis-inducing Activities of Ellagic Acid." Anticancer Research, vol. 26, no. 5A, 2006, pp. 3601-6.
Han DH, Lee MJ, Kim JH. Antioxidant and apoptosis-inducing activities of ellagic acid. Anticancer Res. 2006;26(5A):3601-6.
Han, D. H., Lee, M. J., & Kim, J. H. (2006). Antioxidant and apoptosis-inducing activities of ellagic acid. Anticancer Research, 26(5A), 3601-6.
Han DH, Lee MJ, Kim JH. Antioxidant and Apoptosis-inducing Activities of Ellagic Acid. Anticancer Res. 2006 Sep-Oct;26(5A):3601-6. PubMed PMID: 17094489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and apoptosis-inducing activities of ellagic acid. AU - Han,Dong Hoon, AU - Lee,Min Jeon, AU - Kim,Jeong Hee, PY - 2006/11/11/pubmed PY - 2006/12/9/medline PY - 2006/11/11/entrez SP - 3601 EP - 6 JF - Anticancer research JO - Anticancer Res VL - 26 IS - 5A N2 - BACKGROUND: Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied. MATERIALS AND METHODS: DPPH radical scavenging and lipid peroxidation inhibitory activities were observed. Activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were measured in ellagic acid-treated V79-4 cells. For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. RESULTS: Ellagic acid showed high DPPH radical scavenging and lipid peroxidation inhibition activities. SOD, CAT and GPX activities were significantly increased in ellagic acid-treated V79-4 cells. Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. Bax expression was induced and caspase-3 was activated by ellagic acid treatment. CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/17094489/Antioxidant_and_apoptosis_inducing_activities_of_ellagic_acid_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=17094489 DB - PRIME DP - Unbound Medicine ER -