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Bilateral anorchia in infancy: occurence of micropenis and the effect of testosterone treatment.
J Pediatr. 2006 Nov; 149(5):687-91.JPed

Abstract

OBJECTIVE

To analyze the clinical and histological findings in boys with bilateral anorchia and the response to testosterone treatment on penis length.

STUDY DESIGN

Patients were divided into two groups according to the absence (group A, n = 29) or the presence (group B, n = 26) of palpable intrascrotal or inguinal mass at first clinical examination.

RESULTS

A micropenis was found in 46% of patients (n = 24) with a similar proportion in both groups. Testosterone treatment induced a mean penis length gain of 1.9 +/- 1.3 SDS (standard deviation score). However, micropenis persisted in six patients. Histological examination (n = 18) confirmed the absence of any testicular structure with deferent ducts being present unilaterally or bilaterally in all but three patients. In these three patients, a hemorrhagic testis, probably as a result of a mechanical torsion, was found.

CONCLUSIONS

The presence of isolated micropenis in almost half of patients with bilateral anorchia strongly suggests that the testicular damage frequently occurs during the second half of gestation after male sexual differentiation. In most cases, testosterone treatment stimulates the penile growth. Although the pathogenesis of bilateral anorchia may be heterogeneous, our study suggests that gonads may have been functionally abnormal before they disappeared, and suggests that some patients have an intrinsic endocrine disorder.

Authors+Show Affiliations

Assistance Publique-Hôpitaux de Paris, Robert Debré Hospital, Paediatric Endocrinology Unit and Inserm U457, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

17095345

Citation

Zenaty, D, et al. "Bilateral Anorchia in Infancy: Occurence of Micropenis and the Effect of Testosterone Treatment." The Journal of Pediatrics, vol. 149, no. 5, 2006, pp. 687-91.
Zenaty D, Dijoud F, Morel Y, et al. Bilateral anorchia in infancy: occurence of micropenis and the effect of testosterone treatment. J Pediatr. 2006;149(5):687-91.
Zenaty, D., Dijoud, F., Morel, Y., Cabrol, S., Mouriquand, P., Nicolino, M., Bouvatier, C., Pinto, G., Lecointre, C., Pienkowski, C., Soskin, S., Bost, M., Bertrand, A. M., El-Ghoneimi, A., Nihoul-Fekete, C., & Léger, J. (2006). Bilateral anorchia in infancy: occurence of micropenis and the effect of testosterone treatment. The Journal of Pediatrics, 149(5), 687-91.
Zenaty D, et al. Bilateral Anorchia in Infancy: Occurence of Micropenis and the Effect of Testosterone Treatment. J Pediatr. 2006;149(5):687-91. PubMed PMID: 17095345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bilateral anorchia in infancy: occurence of micropenis and the effect of testosterone treatment. AU - Zenaty,D, AU - Dijoud,F, AU - Morel,Y, AU - Cabrol,S, AU - Mouriquand,P, AU - Nicolino,M, AU - Bouvatier,C, AU - Pinto,G, AU - Lecointre,C, AU - Pienkowski,C, AU - Soskin,S, AU - Bost,M, AU - Bertrand,A M, AU - El-Ghoneimi,A, AU - Nihoul-Fekete,C, AU - Léger,J, PY - 2006/01/03/received PY - 2006/05/05/revised PY - 2006/07/25/accepted PY - 2006/11/11/pubmed PY - 2007/1/5/medline PY - 2006/11/11/entrez SP - 687 EP - 91 JF - The Journal of pediatrics JO - J Pediatr VL - 149 IS - 5 N2 - OBJECTIVE: To analyze the clinical and histological findings in boys with bilateral anorchia and the response to testosterone treatment on penis length. STUDY DESIGN: Patients were divided into two groups according to the absence (group A, n = 29) or the presence (group B, n = 26) of palpable intrascrotal or inguinal mass at first clinical examination. RESULTS: A micropenis was found in 46% of patients (n = 24) with a similar proportion in both groups. Testosterone treatment induced a mean penis length gain of 1.9 +/- 1.3 SDS (standard deviation score). However, micropenis persisted in six patients. Histological examination (n = 18) confirmed the absence of any testicular structure with deferent ducts being present unilaterally or bilaterally in all but three patients. In these three patients, a hemorrhagic testis, probably as a result of a mechanical torsion, was found. CONCLUSIONS: The presence of isolated micropenis in almost half of patients with bilateral anorchia strongly suggests that the testicular damage frequently occurs during the second half of gestation after male sexual differentiation. In most cases, testosterone treatment stimulates the penile growth. Although the pathogenesis of bilateral anorchia may be heterogeneous, our study suggests that gonads may have been functionally abnormal before they disappeared, and suggests that some patients have an intrinsic endocrine disorder. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/17095345/Bilateral_anorchia_in_infancy:_occurence_of_micropenis_and_the_effect_of_testosterone_treatment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(06)00713-X DB - PRIME DP - Unbound Medicine ER -