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Higher antibody, but not cell-mediated, responses to vaccination in high physically fit elderly.
J Appl Physiol (1985) 2007; 102(3):1090-8JA

Abstract

The purpose of this study was to examine whether cardiovascular fitness, independent of confounding factors, was associated with immune responsiveness to clinically relevant challenges in older adults (60-76 yr). Thirteen sedentary, low-fit (LF; maximal O(2) uptake = 21.1 +/- 1.1 ml.kg(-1).min(-1)) and 13 physically active, high-fit (HF; maximal O(2) uptake = 46.8 +/- 3.4 ml.kg(-1).min(-1)) older adults participated in this study. Dietary intake was assessed, and a battery of psychosocial tests was administered. In vivo antibody and ex vivo proliferative and cytokine responses to influenza (Fluzone) and tetanus toxoid (TT) vaccination and delayed-type hypersensitivity skin tests were performed. HF elderly individuals displayed a higher antibody response to two of the three strains included in the Fluzone vaccine as measured by hemagluttination inhibition, but there was no difference between groups in influenza-specific ex vivo proliferation or IFN-gamma or IL-10 production. HF elderly individuals exhibited a lower IgG(1) response and a tendency for a higher IgG(2) response to the TT vaccine. There were, however, no differences in TT-specific ex vivo proliferation or IFN-gamma or IL-10 production. In contrast, HF subjects had higher proliferative responses to phytohemagluttinin. In addition, there were no differences in delayed-type hypersensitivity responses to fungal antigens between groups. These results suggest that, after accounting for confounding factors, HF elderly individuals have higher antibody responses to Fluzone vaccine and a Th2 skewing of the antibody response to TT. There was little evidence that HF mounted better cell-mediated immune responses to the Fluzone or TT vaccine measured in peripheral blood cells or to other recall antigens in vivo.

Authors+Show Affiliations

Depatment of Kinesiology and Community Health, University of Illinois, Urbana, IL 61801, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17095638

Citation

Keylock, K Todd, et al. "Higher Antibody, but Not Cell-mediated, Responses to Vaccination in High Physically Fit Elderly." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 102, no. 3, 2007, pp. 1090-8.
Keylock KT, Lowder T, Leifheit KA, et al. Higher antibody, but not cell-mediated, responses to vaccination in high physically fit elderly. J Appl Physiol. 2007;102(3):1090-8.
Keylock, K. T., Lowder, T., Leifheit, K. A., Cook, M., Mariani, R. A., Ross, K., ... Woods, J. A. (2007). Higher antibody, but not cell-mediated, responses to vaccination in high physically fit elderly. Journal of Applied Physiology (Bethesda, Md. : 1985), 102(3), pp. 1090-8.
Keylock KT, et al. Higher Antibody, but Not Cell-mediated, Responses to Vaccination in High Physically Fit Elderly. J Appl Physiol. 2007;102(3):1090-8. PubMed PMID: 17095638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher antibody, but not cell-mediated, responses to vaccination in high physically fit elderly. AU - Keylock,K Todd, AU - Lowder,Thomas, AU - Leifheit,Kurt A, AU - Cook,Marc, AU - Mariani,Rachel A, AU - Ross,Kristine, AU - Kim,Kijin, AU - Chapman-Novakofski,Karen, AU - McAuley,Edward, AU - Woods,Jeffrey A, Y1 - 2006/11/09/ PY - 2006/11/11/pubmed PY - 2007/5/1/medline PY - 2006/11/11/entrez SP - 1090 EP - 8 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J. Appl. Physiol. VL - 102 IS - 3 N2 - The purpose of this study was to examine whether cardiovascular fitness, independent of confounding factors, was associated with immune responsiveness to clinically relevant challenges in older adults (60-76 yr). Thirteen sedentary, low-fit (LF; maximal O(2) uptake = 21.1 +/- 1.1 ml.kg(-1).min(-1)) and 13 physically active, high-fit (HF; maximal O(2) uptake = 46.8 +/- 3.4 ml.kg(-1).min(-1)) older adults participated in this study. Dietary intake was assessed, and a battery of psychosocial tests was administered. In vivo antibody and ex vivo proliferative and cytokine responses to influenza (Fluzone) and tetanus toxoid (TT) vaccination and delayed-type hypersensitivity skin tests were performed. HF elderly individuals displayed a higher antibody response to two of the three strains included in the Fluzone vaccine as measured by hemagluttination inhibition, but there was no difference between groups in influenza-specific ex vivo proliferation or IFN-gamma or IL-10 production. HF elderly individuals exhibited a lower IgG(1) response and a tendency for a higher IgG(2) response to the TT vaccine. There were, however, no differences in TT-specific ex vivo proliferation or IFN-gamma or IL-10 production. In contrast, HF subjects had higher proliferative responses to phytohemagluttinin. In addition, there were no differences in delayed-type hypersensitivity responses to fungal antigens between groups. These results suggest that, after accounting for confounding factors, HF elderly individuals have higher antibody responses to Fluzone vaccine and a Th2 skewing of the antibody response to TT. There was little evidence that HF mounted better cell-mediated immune responses to the Fluzone or TT vaccine measured in peripheral blood cells or to other recall antigens in vivo. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/17095638/Higher_antibody_but_not_cell_mediated_responses_to_vaccination_in_high_physically_fit_elderly_ L2 - http://journals.physiology.org/doi/full/10.1152/japplphysiol.00790.2006?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -