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Relationships among symptoms, bother, and treatment satisfaction in overactive bladder patients.
Neurourol Urodyn. 2007; 26(2):190-5.NU

Abstract

AIMS

We have studied the association between various symptoms, bother, and patient treatment satisfaction in overactive bladder (OAB).

METHODS

Episodes of urgency, incontinence, daytime frequency and nocturia and responses to the patient perception of bladder condition scale, the urgency perception scale, and visual analog scales of limitations in daily life and of treatment satisfaction were evaluated in 3,824 OAB patients at baseline and during 9 months treatment with tolterodine ER (4 mg q.d.) in an open-label, observational study. Relationships amongst number of symptoms/ 24 hr and scales were explored. Treatment satisfaction was correlated with improvements in symptoms and scales.

RESULTS

At baseline, the number of episodes of the four OAB symptoms correlated only poorly with each other and with the two bother-related scales, while the two scales assessing bother correlated much stronger with each other. Factor analysis identified four components which described "bother," "incontinence," "urgency/frequency," and "nocturia" and in combination explained 81.9% of the total variance. The component "bother" had the strongest individual effect accounting for 42.1% of the total variance. While improvements of symptoms and bother were seen with tolterodine treatment, patient treatment satisfaction correlated strongest with improvements of the two bother-related scales.

CONCLUSIONS

We conclude that the counting of episodes of OAB symptoms only insufficiently describes the afflicted patients. Patient bother is the strongest individual component but only poorly explained by episodes of the four symptoms defining OAB. Alterations of bother may better reflect patient-relevant outcomes in OAB treatment than alterations in the number of symptom episodes.

Authors+Show Affiliations

Department of Pharmacology & Pharmacotherapy, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, Netherlands. m.c.michel@amc.uva.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17096320

Citation

Michel, Martin C., et al. "Relationships Among Symptoms, Bother, and Treatment Satisfaction in Overactive Bladder Patients." Neurourology and Urodynamics, vol. 26, no. 2, 2007, pp. 190-5.
Michel MC, Oelke M, Goepel M, et al. Relationships among symptoms, bother, and treatment satisfaction in overactive bladder patients. Neurourol Urodyn. 2007;26(2):190-5.
Michel, M. C., Oelke, M., Goepel, M., Beck, E., & Burkart, M. (2007). Relationships among symptoms, bother, and treatment satisfaction in overactive bladder patients. Neurourology and Urodynamics, 26(2), 190-5.
Michel MC, et al. Relationships Among Symptoms, Bother, and Treatment Satisfaction in Overactive Bladder Patients. Neurourol Urodyn. 2007;26(2):190-5. PubMed PMID: 17096320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships among symptoms, bother, and treatment satisfaction in overactive bladder patients. AU - Michel,Martin C, AU - Oelke,Matthias, AU - Goepel,Mark, AU - Beck,Elmar, AU - Burkart,Martin, PY - 2006/11/11/pubmed PY - 2007/5/23/medline PY - 2006/11/11/entrez SP - 190 EP - 5 JF - Neurourology and urodynamics JO - Neurourol Urodyn VL - 26 IS - 2 N2 - AIMS: We have studied the association between various symptoms, bother, and patient treatment satisfaction in overactive bladder (OAB). METHODS: Episodes of urgency, incontinence, daytime frequency and nocturia and responses to the patient perception of bladder condition scale, the urgency perception scale, and visual analog scales of limitations in daily life and of treatment satisfaction were evaluated in 3,824 OAB patients at baseline and during 9 months treatment with tolterodine ER (4 mg q.d.) in an open-label, observational study. Relationships amongst number of symptoms/ 24 hr and scales were explored. Treatment satisfaction was correlated with improvements in symptoms and scales. RESULTS: At baseline, the number of episodes of the four OAB symptoms correlated only poorly with each other and with the two bother-related scales, while the two scales assessing bother correlated much stronger with each other. Factor analysis identified four components which described "bother," "incontinence," "urgency/frequency," and "nocturia" and in combination explained 81.9% of the total variance. The component "bother" had the strongest individual effect accounting for 42.1% of the total variance. While improvements of symptoms and bother were seen with tolterodine treatment, patient treatment satisfaction correlated strongest with improvements of the two bother-related scales. CONCLUSIONS: We conclude that the counting of episodes of OAB symptoms only insufficiently describes the afflicted patients. Patient bother is the strongest individual component but only poorly explained by episodes of the four symptoms defining OAB. Alterations of bother may better reflect patient-relevant outcomes in OAB treatment than alterations in the number of symptom episodes. SN - 0733-2467 UR - https://www.unboundmedicine.com/medline/citation/17096320/Relationships_among_symptoms_bother_and_treatment_satisfaction_in_overactive_bladder_patients_ L2 - https://doi.org/10.1002/nau.20367 DB - PRIME DP - Unbound Medicine ER -