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Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly.
Int J Geriatr Psychiatry. 2007 Jun; 22(6):536-42.IJ

Abstract

BACKGROUND

Depression often precedes the onset of Alzheimer's disease (AD) before the appearance of cognitive symptoms. Plasma Amyloid-beta peptide 42 (Abeta42) declines before and soon after the onset of AD, yet the relationship between plasma Abeta42 and depression is unclear.

METHODS

We used 515 homebound elders aged 60 and older in a population-based, cross-sectional study to investigate associations between plasma Abeta levels and depression with and without cardiovascular co-morbidities. Depression was evaluated by using the Center for Epidemiological Studies Depression (CES-D) scale. Plasma Abeta40 and Abeta42 were measured.

RESULTS

The elderly with depression had lower plasma Abeta42 (median: 15.3 vs. 18.9, p = 0.008) than those without depression. The CES-D score was inversely associated with plasma Abeta42 (p = 0.001) in subjects with no cardiovascular disease (CVD); however, in the presence of CVD, this association did not exist. Low plasma Abeta42 (OR = 0.41, p = 0.007) and the presence of CVD (OR = 1.84, p = 0.005) were independently associated with depression after adjusting for the confounders of age, stroke and apolipoprotein E4.

CONCLUSIONS

Depressive symptoms are associated with low plasma Abeta42 independently of CVD. Prospective studies are needed to determine whether depression associated with low plasma Abeta42 is a separate depression subtype that could predict the onset of AD.

Authors+Show Affiliations

Department of Psychiatry, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, USA. wqiu@tufts-nemc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17096467

Citation

Qiu, Wei Qiao, et al. "Depression Is Associated With Low Plasma Abeta42 Independently of Cardiovascular Disease in the Homebound Elderly." International Journal of Geriatric Psychiatry, vol. 22, no. 6, 2007, pp. 536-42.
Qiu WQ, Sun X, Selkoe DJ, et al. Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly. Int J Geriatr Psychiatry. 2007;22(6):536-42.
Qiu, W. Q., Sun, X., Selkoe, D. J., Mwamburi, D. M., Huang, T., Bhadela, R., Bergethon, P., Scott, T. M., Summergrad, P., Wang, L., Rosenberg, I., & Folstein, M. (2007). Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly. International Journal of Geriatric Psychiatry, 22(6), 536-42.
Qiu WQ, et al. Depression Is Associated With Low Plasma Abeta42 Independently of Cardiovascular Disease in the Homebound Elderly. Int J Geriatr Psychiatry. 2007;22(6):536-42. PubMed PMID: 17096467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly. AU - Qiu,Wei Qiao, AU - Sun,Xiaoyan, AU - Selkoe,Dennis J, AU - Mwamburi,D Mkaya, AU - Huang,Tina, AU - Bhadela,Refeeque, AU - Bergethon,Peter, AU - Scott,Tammy M, AU - Summergrad,Paul, AU - Wang,Lixia, AU - Rosenberg,Irwin, AU - Folstein,Marshal, PY - 2006/11/11/pubmed PY - 2007/12/13/medline PY - 2006/11/11/entrez SP - 536 EP - 42 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 22 IS - 6 N2 - BACKGROUND: Depression often precedes the onset of Alzheimer's disease (AD) before the appearance of cognitive symptoms. Plasma Amyloid-beta peptide 42 (Abeta42) declines before and soon after the onset of AD, yet the relationship between plasma Abeta42 and depression is unclear. METHODS: We used 515 homebound elders aged 60 and older in a population-based, cross-sectional study to investigate associations between plasma Abeta levels and depression with and without cardiovascular co-morbidities. Depression was evaluated by using the Center for Epidemiological Studies Depression (CES-D) scale. Plasma Abeta40 and Abeta42 were measured. RESULTS: The elderly with depression had lower plasma Abeta42 (median: 15.3 vs. 18.9, p = 0.008) than those without depression. The CES-D score was inversely associated with plasma Abeta42 (p = 0.001) in subjects with no cardiovascular disease (CVD); however, in the presence of CVD, this association did not exist. Low plasma Abeta42 (OR = 0.41, p = 0.007) and the presence of CVD (OR = 1.84, p = 0.005) were independently associated with depression after adjusting for the confounders of age, stroke and apolipoprotein E4. CONCLUSIONS: Depressive symptoms are associated with low plasma Abeta42 independently of CVD. Prospective studies are needed to determine whether depression associated with low plasma Abeta42 is a separate depression subtype that could predict the onset of AD. SN - 0885-6230 UR - https://www.unboundmedicine.com/medline/citation/17096467/Depression_is_associated_with_low_plasma_Abeta42_independently_of_cardiovascular_disease_in_the_homebound_elderly_ L2 - https://doi.org/10.1002/gps.1710 DB - PRIME DP - Unbound Medicine ER -