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Estrogen receptor alpha gene polymorphism associated with type 2 diabetes mellitus and the serum lipid concentration in Chinese women in Guangzhou.
Chin Med J (Engl). 2006 Nov 05; 119(21):1794-801.CM

Abstract

BACKGROUND

Estrogen might play an important role in type 2 diabetes mellitus pathogenesis. A number of polymorphisms have been reported in the estrogen receptor alpha (ERalpha) gene (also named ESR1), including the XbaI and PvuII restriction enzyme polymorphisms of ESR1, which may be involved in disease pathogenesis. The aim of this study was to determine whether ERX gene polymorphisms are associated with type 2 diabetes mellitus and serum lipid level.

METHODS

Two hundred and ninety-nine patients with type 2 diabetes mellitus were compared with three hundred and forty-one health controls of Guangzhou in China, both were male and postmenopausal female residents at 51 - 70 years. ESR1 genotyping was performed using polymerase chain reaction (PCR) and PvuII and XbaI restriction fragment length polymorphism (PCR-RFLP) analysis.

RESULTS

ESR1 allelic frequencies of P, p and X, x alleles were 0.408, 0.592; 0.360, 0.640 in the type 2 diabetes mellitus group and 0.318, 0.682; 0.328, 0.672 in the control group, respectively. In case-control study, there was significant difference in PvuII, but not XbaI, allele frequency between the type 2 diabetes mellitus and control groups (P = 0.001 and P = 0.122). When the group was separated into men and women, the difference was significant in women (P < 0.001) but not in men (P = 0.854) with the PvuII genotype, and the effect of PvuII variant on the development of type 2 diabetes mellitus was improved with aging. In addition, PvuII genotype was associated with blood glucose [fasting blood glucose (FBG), postprandial blood glucose (PBG)] and serum lipid [total cholesterol (TC) and low density lipoprotein (LDL)-c] concentration in healthy women.

CONCLUSIONS

PvuII polymorphism of ESR1 increases susceptibility to type 2 diabetes mellitus in Chinese Guangzhou women. ESR1 variants may also impact serum lipid metabolism, which might provide a mechanism connecting ESR1 to type 2 diabetes.

Authors+Show Affiliations

Department of Physiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510080, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17097034

Citation

Huang, Qin, et al. "Estrogen Receptor Alpha Gene Polymorphism Associated With Type 2 Diabetes Mellitus and the Serum Lipid Concentration in Chinese Women in Guangzhou." Chinese Medical Journal, vol. 119, no. 21, 2006, pp. 1794-801.
Huang Q, Wang TH, Lu WS, et al. Estrogen receptor alpha gene polymorphism associated with type 2 diabetes mellitus and the serum lipid concentration in Chinese women in Guangzhou. Chin Med J (Engl). 2006;119(21):1794-801.
Huang, Q., Wang, T. H., Lu, W. S., Mu, P. W., Yang, Y. F., Liang, W. W., Li, C. X., & Lin, G. P. (2006). Estrogen receptor alpha gene polymorphism associated with type 2 diabetes mellitus and the serum lipid concentration in Chinese women in Guangzhou. Chinese Medical Journal, 119(21), 1794-801.
Huang Q, et al. Estrogen Receptor Alpha Gene Polymorphism Associated With Type 2 Diabetes Mellitus and the Serum Lipid Concentration in Chinese Women in Guangzhou. Chin Med J (Engl). 2006 Nov 5;119(21):1794-801. PubMed PMID: 17097034.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estrogen receptor alpha gene polymorphism associated with type 2 diabetes mellitus and the serum lipid concentration in Chinese women in Guangzhou. AU - Huang,Qin, AU - Wang,Ting-huai, AU - Lu,Wen-sheng, AU - Mu,Pan-wei, AU - Yang,Yan-fang, AU - Liang,Wei-wen, AU - Li,Cai-xia, AU - Lin,Gui-ping, PY - 2006/11/14/pubmed PY - 2006/12/14/medline PY - 2006/11/14/entrez SP - 1794 EP - 801 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 119 IS - 21 N2 - BACKGROUND: Estrogen might play an important role in type 2 diabetes mellitus pathogenesis. A number of polymorphisms have been reported in the estrogen receptor alpha (ERalpha) gene (also named ESR1), including the XbaI and PvuII restriction enzyme polymorphisms of ESR1, which may be involved in disease pathogenesis. The aim of this study was to determine whether ERX gene polymorphisms are associated with type 2 diabetes mellitus and serum lipid level. METHODS: Two hundred and ninety-nine patients with type 2 diabetes mellitus were compared with three hundred and forty-one health controls of Guangzhou in China, both were male and postmenopausal female residents at 51 - 70 years. ESR1 genotyping was performed using polymerase chain reaction (PCR) and PvuII and XbaI restriction fragment length polymorphism (PCR-RFLP) analysis. RESULTS: ESR1 allelic frequencies of P, p and X, x alleles were 0.408, 0.592; 0.360, 0.640 in the type 2 diabetes mellitus group and 0.318, 0.682; 0.328, 0.672 in the control group, respectively. In case-control study, there was significant difference in PvuII, but not XbaI, allele frequency between the type 2 diabetes mellitus and control groups (P = 0.001 and P = 0.122). When the group was separated into men and women, the difference was significant in women (P < 0.001) but not in men (P = 0.854) with the PvuII genotype, and the effect of PvuII variant on the development of type 2 diabetes mellitus was improved with aging. In addition, PvuII genotype was associated with blood glucose [fasting blood glucose (FBG), postprandial blood glucose (PBG)] and serum lipid [total cholesterol (TC) and low density lipoprotein (LDL)-c] concentration in healthy women. CONCLUSIONS: PvuII polymorphism of ESR1 increases susceptibility to type 2 diabetes mellitus in Chinese Guangzhou women. ESR1 variants may also impact serum lipid metabolism, which might provide a mechanism connecting ESR1 to type 2 diabetes. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/17097034/Estrogen_receptor_alpha_gene_polymorphism_associated_with_type_2_diabetes_mellitus_and_the_serum_lipid_concentration_in_Chinese_women_in_Guangzhou_ L2 - https://Insights.ovid.com/pubmed?pmid=17097034 DB - PRIME DP - Unbound Medicine ER -