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Affective neural circuitry during facial emotion processing in pediatric bipolar disorder.
Biol Psychiatry. 2007 Jul 15; 62(2):158-67.BP

Abstract

BACKGROUND

Facial emotions are central to human interaction. Identifying pathophysiology in affect processing circuitry that supports the ability to assess facial emotions might facilitate understanding of affect regulation in pediatric bipolar disorder.

METHODS

Ten euthymic, unmedicated pediatric bipolar patients and 10 healthy control subjects matched for age, gender, race, socioeconomic status, and IQ were scanned with functional magnetic resonance imaging. Angry, happy, and neutral faces were presented in 30-sec blocks, with a 20-sec rest period between blocks. Subjects were asked to press a button when each face appeared, to ensure that attention was maintained on-task.

RESULTS

In bipolar patients, in response to both angry and happy faces relative to neutral faces, we observed reduced activation of right rostral ventrolateral prefrontal cortex together with increased activity in right pregenual anterior cingulate, amygdala, and paralimbic cortex. Bipolar patients also showed reduced activation of visual areas in occipital cortex together with greater activation in higher-order visual perceptual areas, including superior temporal sulcus and fusiform gyrus with angry faces and posterior parietal cortex with happy faces.

CONCLUSIONS

Findings document a disturbance in affective neurocircuitry in pediatric bipolar disorder. Reduced activation in ventrolateral prefrontal cortex might reflect diminished top-down control that leads to the observed exaggerated activation in amygdala and paralimbic areas. Changes in occipital areas might represent an effort to gate sensory input when affective responses to the faces could not be successfully modulated. Disturbances in affect processing circuitry could contribute to emotional dysregulation and social cognitive difficulties in bipolar youth.

Authors+Show Affiliations

Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA. mpavuluri@psych.uic.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17097071

Citation

Pavuluri, Mani N., et al. "Affective Neural Circuitry During Facial Emotion Processing in Pediatric Bipolar Disorder." Biological Psychiatry, vol. 62, no. 2, 2007, pp. 158-67.
Pavuluri MN, O'Connor MM, Harral E, et al. Affective neural circuitry during facial emotion processing in pediatric bipolar disorder. Biol Psychiatry. 2007;62(2):158-67.
Pavuluri, M. N., O'Connor, M. M., Harral, E., & Sweeney, J. A. (2007). Affective neural circuitry during facial emotion processing in pediatric bipolar disorder. Biological Psychiatry, 62(2), 158-67.
Pavuluri MN, et al. Affective Neural Circuitry During Facial Emotion Processing in Pediatric Bipolar Disorder. Biol Psychiatry. 2007 Jul 15;62(2):158-67. PubMed PMID: 17097071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Affective neural circuitry during facial emotion processing in pediatric bipolar disorder. AU - Pavuluri,Mani N, AU - O'Connor,Megan Marlow, AU - Harral,Erin, AU - Sweeney,John A, Y1 - 2006/11/09/ PY - 2006/06/26/received PY - 2006/07/12/revised PY - 2006/07/13/accepted PY - 2006/11/14/pubmed PY - 2007/8/19/medline PY - 2006/11/14/entrez SP - 158 EP - 67 JF - Biological psychiatry JO - Biol Psychiatry VL - 62 IS - 2 N2 - BACKGROUND: Facial emotions are central to human interaction. Identifying pathophysiology in affect processing circuitry that supports the ability to assess facial emotions might facilitate understanding of affect regulation in pediatric bipolar disorder. METHODS: Ten euthymic, unmedicated pediatric bipolar patients and 10 healthy control subjects matched for age, gender, race, socioeconomic status, and IQ were scanned with functional magnetic resonance imaging. Angry, happy, and neutral faces were presented in 30-sec blocks, with a 20-sec rest period between blocks. Subjects were asked to press a button when each face appeared, to ensure that attention was maintained on-task. RESULTS: In bipolar patients, in response to both angry and happy faces relative to neutral faces, we observed reduced activation of right rostral ventrolateral prefrontal cortex together with increased activity in right pregenual anterior cingulate, amygdala, and paralimbic cortex. Bipolar patients also showed reduced activation of visual areas in occipital cortex together with greater activation in higher-order visual perceptual areas, including superior temporal sulcus and fusiform gyrus with angry faces and posterior parietal cortex with happy faces. CONCLUSIONS: Findings document a disturbance in affective neurocircuitry in pediatric bipolar disorder. Reduced activation in ventrolateral prefrontal cortex might reflect diminished top-down control that leads to the observed exaggerated activation in amygdala and paralimbic areas. Changes in occipital areas might represent an effort to gate sensory input when affective responses to the faces could not be successfully modulated. Disturbances in affect processing circuitry could contribute to emotional dysregulation and social cognitive difficulties in bipolar youth. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/17097071/Affective_neural_circuitry_during_facial_emotion_processing_in_pediatric_bipolar_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(06)00907-3 DB - PRIME DP - Unbound Medicine ER -