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Predictions of tensile strength of binary tablets using linear and power law mixing rules.
Int J Pharm. 2007 Mar 21; 333(1-2):118-26.IJ

Abstract

There has recently been an increased interest in predicting the tensile strength of binary tablets from the properties of the individual components. In this paper, measurements are reported for tensile strength of tablets compressed from single-component and binary powder mixtures of lactose with microcrystalline cellulose (MCC), and lactose with two types of silicified microcrystalline cellulose (SMCC and SMCC-HD), which are different in compressibility. Measurements show the tensile strength increases with the relative density for single powders, and both with the relative density and the mass fraction of cellulose in the mixtures. It was also observed, for binary mixtures compacted at 50 and 150 MPa, that there was a slight variation in porosity with the mass fraction of celluloses. The predictions of the tensile strength of binary tablets from the characteristics of the single-components was analysed with the extended Ryshkewitch-Duckworth model by assuming both linear and power law mixing rules for the determination of the parameters "tensile strength at zero porosity and bonding capacity constant". As consequence, four models were analysed and compared with measurements using criteria based on the standard deviation from the mean values. Results showed a good prediction using a linear mixing rule combined with the power law. However, as the predictions of these models depend on the powders and the porosity range for the characterization of single-components, none of them can be systematically considered as being the best to predict binary behaviour from data for individual powders.

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Authors+Show Affiliations

Michrafy A
Chemical Engineering Laboratory for Particulate Solids, UMR CNRS 2392, Ecole des Mines d'Albi-Carmaux, Campus Jarlard, Albi, France. michrafy@enstimac.fr
Michrafy M
No affiliation info available
Kadiri MS
No affiliation info available
Dodds JA
No affiliation info available

MeSH

CelluloseChemistry, PharmaceuticalDrug CompoundingExcipientsLactoseLinear ModelsModels, ChemicalPorosityPowdersPredictive Value of TestsReproducibility of ResultsSurface PropertiesTabletsTechnology, PharmaceuticalTensile Strength

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17097245

Citation

Michrafy, A, et al. "Predictions of Tensile Strength of Binary Tablets Using Linear and Power Law Mixing Rules." International Journal of Pharmaceutics, vol. 333, no. 1-2, 2007, pp. 118-26.
Michrafy A, Michrafy M, Kadiri MS, et al. Predictions of tensile strength of binary tablets using linear and power law mixing rules. Int J Pharm. 2007;333(1-2):118-26.
Michrafy, A., Michrafy, M., Kadiri, M. S., & Dodds, J. A. (2007). Predictions of tensile strength of binary tablets using linear and power law mixing rules. International Journal of Pharmaceutics, 333(1-2), 118-26.
Michrafy A, et al. Predictions of Tensile Strength of Binary Tablets Using Linear and Power Law Mixing Rules. Int J Pharm. 2007 Mar 21;333(1-2):118-26. PubMed PMID: 17097245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictions of tensile strength of binary tablets using linear and power law mixing rules. AU - Michrafy,A, AU - Michrafy,M, AU - Kadiri,M S, AU - Dodds,J A, Y1 - 2006/10/10/ PY - 2005/12/19/received PY - 2006/10/03/revised PY - 2006/10/06/accepted PY - 2006/11/14/pubmed PY - 2007/5/5/medline PY - 2006/11/14/entrez SP - 118 EP - 26 JF - International journal of pharmaceutics JO - Int J Pharm VL - 333 IS - 1-2 N2 - There has recently been an increased interest in predicting the tensile strength of binary tablets from the properties of the individual components. In this paper, measurements are reported for tensile strength of tablets compressed from single-component and binary powder mixtures of lactose with microcrystalline cellulose (MCC), and lactose with two types of silicified microcrystalline cellulose (SMCC and SMCC-HD), which are different in compressibility. Measurements show the tensile strength increases with the relative density for single powders, and both with the relative density and the mass fraction of cellulose in the mixtures. It was also observed, for binary mixtures compacted at 50 and 150 MPa, that there was a slight variation in porosity with the mass fraction of celluloses. The predictions of the tensile strength of binary tablets from the characteristics of the single-components was analysed with the extended Ryshkewitch-Duckworth model by assuming both linear and power law mixing rules for the determination of the parameters "tensile strength at zero porosity and bonding capacity constant". As consequence, four models were analysed and compared with measurements using criteria based on the standard deviation from the mean values. Results showed a good prediction using a linear mixing rule combined with the power law. However, as the predictions of these models depend on the powders and the porosity range for the characterization of single-components, none of them can be systematically considered as being the best to predict binary behaviour from data for individual powders. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/17097245/Predictions_of_tensile_strength_of_binary_tablets_using_linear_and_power_law_mixing_rules_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(06)00847-7 DB - PRIME DP - Unbound Medicine ER -