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Transcranial magnetic stimulation over dorsolateral prefrontal cortex in Parkinson's disease.
Clin Neurophysiol. 2007 Jan; 118(1):131-9.CN

Abstract

OBJECTIVE

Several studies have shown that repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) is effective in the treatment of depression in patients with Parkinson disease (PD). However, since research into the effect of this type of rTMS regime on motor function is limited, we studied the effect of rTMS over the DLPFC on the motor functions in PD patients.

METHODS

Thirteen patients were randomly assigned into 2 groups, one receiving real-rTMS (90% of resting motor threshold, 10 Hz, 450 pulses-day for 10 consecutive days) over the DLPFC contralateral to the more affected side, and the other group receiving sham-rTMS. Assessment included a clinical motor evaluation using part III of the Unified Parkinson's Disease Rating Scale (UPDRS), and several motor tasks. The UPDRS was applied before and after 10 days of rTMS. Finger tapping, reach movement, grip movement and gait were measured in each session before and after the rTMS over the 10 day period.

RESULTS

Statistical analysis (ANOVA for repeated measures; group *day *side *rTMS) only showed a significant effect for finger tapping, reach movement and gait for the factor day. No significant change was reported for the UPDRS in any group.

CONCLUSIONS

Application of rTMS over the DLPFC as a 10 day course had no significant effect on motor functions and clinical motor status, and the improvement in performance of motor tasks can be attributed to the effects of practice.

SIGNIFICANCE

rTMS over the DLPFC did not lead to any motor improvement in PD patients.

Authors+Show Affiliations

Neuroscience and Motor Control Group (NEUROcom), University of A Coruña, A Coruña, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17097342

Citation

del Olmo, Miguel Fernández, et al. "Transcranial Magnetic Stimulation Over Dorsolateral Prefrontal Cortex in Parkinson's Disease." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 118, no. 1, 2007, pp. 131-9.
del Olmo MF, Bello O, Cudeiro J. Transcranial magnetic stimulation over dorsolateral prefrontal cortex in Parkinson's disease. Clin Neurophysiol. 2007;118(1):131-9.
del Olmo, M. F., Bello, O., & Cudeiro, J. (2007). Transcranial magnetic stimulation over dorsolateral prefrontal cortex in Parkinson's disease. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 118(1), 131-9.
del Olmo MF, Bello O, Cudeiro J. Transcranial Magnetic Stimulation Over Dorsolateral Prefrontal Cortex in Parkinson's Disease. Clin Neurophysiol. 2007;118(1):131-9. PubMed PMID: 17097342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transcranial magnetic stimulation over dorsolateral prefrontal cortex in Parkinson's disease. AU - del Olmo,Miguel Fernández, AU - Bello,Olalla, AU - Cudeiro,Javier, Y1 - 2006/11/09/ PY - 2006/01/18/received PY - 2006/08/18/revised PY - 2006/09/05/accepted PY - 2006/11/14/pubmed PY - 2007/3/28/medline PY - 2006/11/14/entrez SP - 131 EP - 9 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 118 IS - 1 N2 - OBJECTIVE: Several studies have shown that repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) is effective in the treatment of depression in patients with Parkinson disease (PD). However, since research into the effect of this type of rTMS regime on motor function is limited, we studied the effect of rTMS over the DLPFC on the motor functions in PD patients. METHODS: Thirteen patients were randomly assigned into 2 groups, one receiving real-rTMS (90% of resting motor threshold, 10 Hz, 450 pulses-day for 10 consecutive days) over the DLPFC contralateral to the more affected side, and the other group receiving sham-rTMS. Assessment included a clinical motor evaluation using part III of the Unified Parkinson's Disease Rating Scale (UPDRS), and several motor tasks. The UPDRS was applied before and after 10 days of rTMS. Finger tapping, reach movement, grip movement and gait were measured in each session before and after the rTMS over the 10 day period. RESULTS: Statistical analysis (ANOVA for repeated measures; group *day *side *rTMS) only showed a significant effect for finger tapping, reach movement and gait for the factor day. No significant change was reported for the UPDRS in any group. CONCLUSIONS: Application of rTMS over the DLPFC as a 10 day course had no significant effect on motor functions and clinical motor status, and the improvement in performance of motor tasks can be attributed to the effects of practice. SIGNIFICANCE: rTMS over the DLPFC did not lead to any motor improvement in PD patients. SN - 1388-2457 UR - https://www.unboundmedicine.com/medline/citation/17097342/Transcranial_magnetic_stimulation_over_dorsolateral_prefrontal_cortex_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(06)01434-9 DB - PRIME DP - Unbound Medicine ER -