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Modulation of motor cortical excitability following rapid-rate transcranial magnetic stimulation.
Clin Neurophysiol. 2007 Jan; 118(1):140-5.CN

Abstract

OBJECTIVE

To investigate the effect of high frequency rTMS (25 Hz at 90-100% of resting motor threshold) on the excitability of the motor cortex of healthy human subjects.

METHODS

Resting and active motor threshold, MEP recruitment curve (I/O curve), short interval intracortical inhibition (SICI) and facilitation (ICF), and the duration of the silent period (SP) were tested in the right first dorsal interosseous muscle (FDI) before and twice after the end of 1500 pulses in 16 normal young adult male volunteers.

RESULTS

Twenty-five Hertz rTMS decreased motor thresholds, reduced the duration of the silent period and had a tendency to increase the slope of the I/O curve. Most of these effects lasted for the duration of the two post-testing sessions (at least 30 min) and had returned to normal by 2h. There were no significant effects on SICI/ICF.

CONCLUSION

Twenty-five Hertz rTMS can produce a long lasting increase in cortical excitability in healthy subjects.

SIGNIFICANCE

This method may prove useful for the study of normal human physiology and for therapeutic manipulation of brain plasticity.

Authors+Show Affiliations

Department of Neurology, Assiut University Hospital, Assiut, Egypt. emankhedr99@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17097343

Citation

Khedr, Eman M., et al. "Modulation of Motor Cortical Excitability Following Rapid-rate Transcranial Magnetic Stimulation." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 118, no. 1, 2007, pp. 140-5.
Khedr EM, Rothwell JC, Ahmed MA, et al. Modulation of motor cortical excitability following rapid-rate transcranial magnetic stimulation. Clin Neurophysiol. 2007;118(1):140-5.
Khedr, E. M., Rothwell, J. C., Ahmed, M. A., Shawky, O. A., & Farouk, M. (2007). Modulation of motor cortical excitability following rapid-rate transcranial magnetic stimulation. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 118(1), 140-5.
Khedr EM, et al. Modulation of Motor Cortical Excitability Following Rapid-rate Transcranial Magnetic Stimulation. Clin Neurophysiol. 2007;118(1):140-5. PubMed PMID: 17097343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of motor cortical excitability following rapid-rate transcranial magnetic stimulation. AU - Khedr,Eman M, AU - Rothwell,John C, AU - Ahmed,Mohamed A, AU - Shawky,Ola A, AU - Farouk,Mona, Y1 - 2006/11/09/ PY - 2006/05/07/received PY - 2006/08/25/revised PY - 2006/09/11/accepted PY - 2006/11/14/pubmed PY - 2007/3/28/medline PY - 2006/11/14/entrez SP - 140 EP - 5 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 118 IS - 1 N2 - OBJECTIVE: To investigate the effect of high frequency rTMS (25 Hz at 90-100% of resting motor threshold) on the excitability of the motor cortex of healthy human subjects. METHODS: Resting and active motor threshold, MEP recruitment curve (I/O curve), short interval intracortical inhibition (SICI) and facilitation (ICF), and the duration of the silent period (SP) were tested in the right first dorsal interosseous muscle (FDI) before and twice after the end of 1500 pulses in 16 normal young adult male volunteers. RESULTS: Twenty-five Hertz rTMS decreased motor thresholds, reduced the duration of the silent period and had a tendency to increase the slope of the I/O curve. Most of these effects lasted for the duration of the two post-testing sessions (at least 30 min) and had returned to normal by 2h. There were no significant effects on SICI/ICF. CONCLUSION: Twenty-five Hertz rTMS can produce a long lasting increase in cortical excitability in healthy subjects. SIGNIFICANCE: This method may prove useful for the study of normal human physiology and for therapeutic manipulation of brain plasticity. SN - 1388-2457 UR - https://www.unboundmedicine.com/medline/citation/17097343/Modulation_of_motor_cortical_excitability_following_rapid_rate_transcranial_magnetic_stimulation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(06)01440-4 DB - PRIME DP - Unbound Medicine ER -