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MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study.
Neurobiol Aging. 2008 Jan; 29(1):31-8.NA

Abstract

The concept of mild cognitive impairment (MCI) has been proposed to represent a transitional stage between normal aging and dementia. We studied the predictive value of the MRI-derived volumes of medial temporal lobe (MTL) structures, white matter lesions (WML), neuropsychological tests, and Apolipoprotein E (APOE) genotype on conversion of MCI to dementia and AD. The study included 60 subjects with MCI identified from population cohorts. During the mean follow-up period of 34 months, 13 patients had progressed to dementia (9 to Alzheimer's disease (AD)). In Cox regression analysis the baseline volumes of the right hippocampus, the right entorhinal cortex and CDR sum of boxes predicted the progression of MCI to dementia during the follow-up. In a bivariate analysis, only the baseline volumes of entorhinal cortex predicted conversion of MCI to AD. The Mini-Mental State Examination (MMSE) score at baseline, WML load, or APOE genotype were not significant predictors of progression. The MTL volumetry helps in identifying among the MCI subjects a group, which is at high risk for developing AD.

Authors+Show Affiliations

Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland. tero.tapiola@uku.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17097769

Citation

Tapiola, Tero, et al. "MRI of Hippocampus and Entorhinal Cortex in Mild Cognitive Impairment: a Follow-up Study." Neurobiology of Aging, vol. 29, no. 1, 2008, pp. 31-8.
Tapiola T, Pennanen C, Tapiola M, et al. MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study. Neurobiol Aging. 2008;29(1):31-8.
Tapiola, T., Pennanen, C., Tapiola, M., Tervo, S., Kivipelto, M., Hänninen, T., Pihlajamäki, M., Laakso, M. P., Hallikainen, M., Hämäläinen, A., Vanhanen, M., Helkala, E. L., Vanninen, R., Nissinen, A., Rossi, R., Frisoni, G. B., & Soininen, H. (2008). MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study. Neurobiology of Aging, 29(1), 31-8.
Tapiola T, et al. MRI of Hippocampus and Entorhinal Cortex in Mild Cognitive Impairment: a Follow-up Study. Neurobiol Aging. 2008;29(1):31-8. PubMed PMID: 17097769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study. AU - Tapiola,Tero, AU - Pennanen,Corina, AU - Tapiola,Mia, AU - Tervo,Susanna, AU - Kivipelto,Miia, AU - Hänninen,Tuomo, AU - Pihlajamäki,Maija, AU - Laakso,Mikko P, AU - Hallikainen,Merja, AU - Hämäläinen,Anne, AU - Vanhanen,Matti, AU - Helkala,Eeva-Liisa, AU - Vanninen,Ritva, AU - Nissinen,Aulikki, AU - Rossi,Roberta, AU - Frisoni,Giovanni B, AU - Soininen,Hilkka, Y1 - 2006/11/13/ PY - 2006/04/13/received PY - 2006/08/16/revised PY - 2006/09/15/accepted PY - 2006/11/14/pubmed PY - 2008/2/1/medline PY - 2006/11/14/entrez SP - 31 EP - 8 JF - Neurobiology of aging JO - Neurobiol Aging VL - 29 IS - 1 N2 - The concept of mild cognitive impairment (MCI) has been proposed to represent a transitional stage between normal aging and dementia. We studied the predictive value of the MRI-derived volumes of medial temporal lobe (MTL) structures, white matter lesions (WML), neuropsychological tests, and Apolipoprotein E (APOE) genotype on conversion of MCI to dementia and AD. The study included 60 subjects with MCI identified from population cohorts. During the mean follow-up period of 34 months, 13 patients had progressed to dementia (9 to Alzheimer's disease (AD)). In Cox regression analysis the baseline volumes of the right hippocampus, the right entorhinal cortex and CDR sum of boxes predicted the progression of MCI to dementia during the follow-up. In a bivariate analysis, only the baseline volumes of entorhinal cortex predicted conversion of MCI to AD. The Mini-Mental State Examination (MMSE) score at baseline, WML load, or APOE genotype were not significant predictors of progression. The MTL volumetry helps in identifying among the MCI subjects a group, which is at high risk for developing AD. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/17097769/MRI_of_hippocampus_and_entorhinal_cortex_in_mild_cognitive_impairment:_a_follow_up_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(06)00345-9 DB - PRIME DP - Unbound Medicine ER -