Tags

Type your tag names separated by a space and hit enter

Attenuation of the hypothalamic-pituitary-adrenal axis responsivity to the Trier Social Stress Test by the benzodiazepine alprazolam.
Psychoneuroendocrinology. 2006 Nov; 31(10):1278-88.P

Abstract

Little is known about effects of commonly used anxiolytic drugs on psychologically evoked responses of two major stress systems, the hypothalamic-pituitary-adrenal (HPA) and the sympathetic-adrenal-medullary (SAM) axis. The purpose of the present study was to assess effects of the anxiolytic alprazolam on responses of the HPA and the SAM axes to a standardized psychosocial stress protocol, the Trier Social Stress Test (TSST). Forty-six healthy, non-smoking, non-medicated males, aged between 18 and 45 years, were invited once to the laboratory and received a single oral dose of 1mg alprazolam or placebo, respectively, 1h prior to the TSST. The secretion of ACTH, cortisol, epinephrine, norepinephrine as well as changes in heart rate, blood pressure, and psychological states (anxiety, wakefulness, good mood, calmness) in response to the TSST were measured. Subjects pre-treated with alprazolam showed a strongly blunted response of ACTH as well as total and free cortisol to the TSST. Whereas alprazolam-treated subjects displayed significantly lower systolic blood pressure immediately before the TSST, neither the secretion of epinephrine, norepinephrine nor changes of heart rate in response to the stress test differed from placebo-treated subjects. Regarding psychological parameters, alprazolam clearly decreased subjective ratings on the questionnaire scale "wakefulness" and increased ratings on the scale "good mood", whereas ratings on scales assessing "state anxiety" or "agitation" were not affected. In healthy subjects, we observed a dissociation of the effects of alprazolam on the endocrine and the autonomic response to psychosocial stress. The psychological responses seemed to be masked by sedative properties of alprazolam.

Authors+Show Affiliations

Daacro-Clinical Research Organization, Novalisstrasse 12 a, 54295 Trier, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17097811

Citation

Fries, Eva, et al. "Attenuation of the Hypothalamic-pituitary-adrenal Axis Responsivity to the Trier Social Stress Test By the Benzodiazepine Alprazolam." Psychoneuroendocrinology, vol. 31, no. 10, 2006, pp. 1278-88.
Fries E, Hellhammer DH, Hellhammer J. Attenuation of the hypothalamic-pituitary-adrenal axis responsivity to the Trier Social Stress Test by the benzodiazepine alprazolam. Psychoneuroendocrinology. 2006;31(10):1278-88.
Fries, E., Hellhammer, D. H., & Hellhammer, J. (2006). Attenuation of the hypothalamic-pituitary-adrenal axis responsivity to the Trier Social Stress Test by the benzodiazepine alprazolam. Psychoneuroendocrinology, 31(10), 1278-88.
Fries E, Hellhammer DH, Hellhammer J. Attenuation of the Hypothalamic-pituitary-adrenal Axis Responsivity to the Trier Social Stress Test By the Benzodiazepine Alprazolam. Psychoneuroendocrinology. 2006;31(10):1278-88. PubMed PMID: 17097811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attenuation of the hypothalamic-pituitary-adrenal axis responsivity to the Trier Social Stress Test by the benzodiazepine alprazolam. AU - Fries,Eva, AU - Hellhammer,Dirk H, AU - Hellhammer,Juliane, Y1 - 2006/11/13/ PY - 2006/07/25/received PY - 2006/09/21/revised PY - 2006/09/21/accepted PY - 2006/11/14/pubmed PY - 2007/3/21/medline PY - 2006/11/14/entrez SP - 1278 EP - 88 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 31 IS - 10 N2 - Little is known about effects of commonly used anxiolytic drugs on psychologically evoked responses of two major stress systems, the hypothalamic-pituitary-adrenal (HPA) and the sympathetic-adrenal-medullary (SAM) axis. The purpose of the present study was to assess effects of the anxiolytic alprazolam on responses of the HPA and the SAM axes to a standardized psychosocial stress protocol, the Trier Social Stress Test (TSST). Forty-six healthy, non-smoking, non-medicated males, aged between 18 and 45 years, were invited once to the laboratory and received a single oral dose of 1mg alprazolam or placebo, respectively, 1h prior to the TSST. The secretion of ACTH, cortisol, epinephrine, norepinephrine as well as changes in heart rate, blood pressure, and psychological states (anxiety, wakefulness, good mood, calmness) in response to the TSST were measured. Subjects pre-treated with alprazolam showed a strongly blunted response of ACTH as well as total and free cortisol to the TSST. Whereas alprazolam-treated subjects displayed significantly lower systolic blood pressure immediately before the TSST, neither the secretion of epinephrine, norepinephrine nor changes of heart rate in response to the stress test differed from placebo-treated subjects. Regarding psychological parameters, alprazolam clearly decreased subjective ratings on the questionnaire scale "wakefulness" and increased ratings on the scale "good mood", whereas ratings on scales assessing "state anxiety" or "agitation" were not affected. In healthy subjects, we observed a dissociation of the effects of alprazolam on the endocrine and the autonomic response to psychosocial stress. The psychological responses seemed to be masked by sedative properties of alprazolam. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/17097811/Attenuation_of_the_hypothalamic_pituitary_adrenal_axis_responsivity_to_the_Trier_Social_Stress_Test_by_the_benzodiazepine_alprazolam_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(06)00153-3 DB - PRIME DP - Unbound Medicine ER -