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Carotid intima-media thickness in patients with abdominal aortic aneurysms.
Eur J Vasc Endovasc Surg. 2007 Feb; 33(2):149-53.EJ

Abstract

OBJECTIVE

The contribution of atherosclerosis to the development of Abdominal Aortic Aneurysms (AAA) is still controversial. Ultrasound scans can detect intima-media thickening of the carotid arteries as an early sign of atherosclerosis. The aim of this study was to investigate whether patients with Abdominal Aortic Aneurysms (AAAs) have thickened carotid IMT as patients with atherosclerotic peripheral arterial disease (PAD).

METHODS

With high-resolution B-mode ultrasonography, the intima-media thickness (IMT) in the carotid arteries (right and left common carotid artery) was measured in AAA patients and compared with that of age and sex-matched patients with atherosclerotic peripheral arterial disease (PAD). A third group of healthy age and sex- matched control subjects were included for comparison. The corresponding carotid artery lumen was also determined in all groups. Comparison of the three groups was made by ANOVA.

RESULTS

Fifty-eight AAA patients and 69% were men (mean age of 72.3 years) were studied. Aged and sex-matched groups comprised of 111 PAD patients and 71 healthy. The mean carotid IMT was highest in PAD patients (1.036+/-0.18mm). The values of controls and AAA patients were similar and significantly lower than that of atherosclerotic patients (0.875+/-0.11mm and 0.812+/-0.53mm respectively, both p<0.005 vs. PAD). Narrowing of the corresponding lumen was found in PAD patients compared with that of AAA patients, but no difference can be seen between healthy subjects and AAA patients. The mean carotid IMT was greater in men (P<0.05) in all studied groups, but no similar gender specificity was found in the lumen diameter.

CONCLUSIONS

This study shows that the carotid artery IMT of AAA patients is similar to healthy subjects, but not as thick as patients with atherosclerotic disease. As carotid (IMT) is a surrogate marker of atherosclerosis, the findings support the notion that the formation of AAA may not be fully atherosclerosis-dependent. Gender may be a confounding factor for carotid intima-media thickening.

Authors+Show Affiliations

Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17097902

Citation

Cheuk, Bernice L Y., et al. "Carotid Intima-media Thickness in Patients With Abdominal Aortic Aneurysms." European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, vol. 33, no. 2, 2007, pp. 149-53.
Cheuk BL, Lau SS, Cheng SW. Carotid intima-media thickness in patients with abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2007;33(2):149-53.
Cheuk, B. L., Lau, S. S., & Cheng, S. W. (2007). Carotid intima-media thickness in patients with abdominal aortic aneurysms. European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, 33(2), 149-53.
Cheuk BL, Lau SS, Cheng SW. Carotid Intima-media Thickness in Patients With Abdominal Aortic Aneurysms. Eur J Vasc Endovasc Surg. 2007;33(2):149-53. PubMed PMID: 17097902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carotid intima-media thickness in patients with abdominal aortic aneurysms. AU - Cheuk,Bernice L Y, AU - Lau,Silvana S F, AU - Cheng,Stephen W K, Y1 - 2006/11/09/ PY - 2006/06/26/received PY - 2006/09/04/accepted PY - 2006/11/14/pubmed PY - 2007/3/16/medline PY - 2006/11/14/entrez SP - 149 EP - 53 JF - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery JO - Eur J Vasc Endovasc Surg VL - 33 IS - 2 N2 - OBJECTIVE: The contribution of atherosclerosis to the development of Abdominal Aortic Aneurysms (AAA) is still controversial. Ultrasound scans can detect intima-media thickening of the carotid arteries as an early sign of atherosclerosis. The aim of this study was to investigate whether patients with Abdominal Aortic Aneurysms (AAAs) have thickened carotid IMT as patients with atherosclerotic peripheral arterial disease (PAD). METHODS: With high-resolution B-mode ultrasonography, the intima-media thickness (IMT) in the carotid arteries (right and left common carotid artery) was measured in AAA patients and compared with that of age and sex-matched patients with atherosclerotic peripheral arterial disease (PAD). A third group of healthy age and sex- matched control subjects were included for comparison. The corresponding carotid artery lumen was also determined in all groups. Comparison of the three groups was made by ANOVA. RESULTS: Fifty-eight AAA patients and 69% were men (mean age of 72.3 years) were studied. Aged and sex-matched groups comprised of 111 PAD patients and 71 healthy. The mean carotid IMT was highest in PAD patients (1.036+/-0.18mm). The values of controls and AAA patients were similar and significantly lower than that of atherosclerotic patients (0.875+/-0.11mm and 0.812+/-0.53mm respectively, both p<0.005 vs. PAD). Narrowing of the corresponding lumen was found in PAD patients compared with that of AAA patients, but no difference can be seen between healthy subjects and AAA patients. The mean carotid IMT was greater in men (P<0.05) in all studied groups, but no similar gender specificity was found in the lumen diameter. CONCLUSIONS: This study shows that the carotid artery IMT of AAA patients is similar to healthy subjects, but not as thick as patients with atherosclerotic disease. As carotid (IMT) is a surrogate marker of atherosclerosis, the findings support the notion that the formation of AAA may not be fully atherosclerosis-dependent. Gender may be a confounding factor for carotid intima-media thickening. SN - 1078-5884 UR - https://www.unboundmedicine.com/medline/citation/17097902/Carotid_intima_media_thickness_in_patients_with_abdominal_aortic_aneurysms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078-5884(06)00506-5 DB - PRIME DP - Unbound Medicine ER -