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Regional gray matter volume abnormalities in the at risk mental state.
Biol Psychiatry 2007; 61(10):1148-56BP

Abstract

BACKGROUND

Individuals with an At Risk Mental State (ARMS) have a very high risk of developing a psychotic disorder but the basis of this risk is unclear. We addressed this issue by studying gray matter volume in this group with magnetic resonance imaging (MRI).

METHODS

Thirty-five individuals with an ARMS, 25 patients with first episode schizophrenia, and 22 healthy volunteers were studied using a 1.5T MRI scanner. Twelve (34%) of the ARMS group developed schizophrenia in the 2 years subsequent to scanning.

RESULTS

There were significant volumetric differences between the three groups in the left insula, superior temporal gyrus, cingulate gyrus and precuneus. In these regions, the volume in the ARMS group was smaller than in volunteers but not significantly different from that in the first episode (FE) group. Direct comparison of the ARMS and control groups revealed additional areas of reduced volume in the left medial temporal cortex. Within the ARMS group, those subjects who later developed psychosis had less gray matter than subjects who did not in the right insula, inferior frontal and superior temporal gyrus.

CONCLUSIONS

The ARMS was associated with reductions in gray matter volume in areas that are also reduced in schizophrenia, suggesting that these are a correlate of an increased vulnerability to psychosis. Volumetric differences within the ARMS group may be related to the subsequent onset of schizophrenia in a subset of those at high risk.

Authors+Show Affiliations

Psychiatric Outpatient Department, University Hospital Basel, Switzerland. sborgwardt@uhbs.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17098213

Citation

Borgwardt, Stefan J., et al. "Regional Gray Matter Volume Abnormalities in the at Risk Mental State." Biological Psychiatry, vol. 61, no. 10, 2007, pp. 1148-56.
Borgwardt SJ, Riecher-Rössler A, Dazzan P, et al. Regional gray matter volume abnormalities in the at risk mental state. Biol Psychiatry. 2007;61(10):1148-56.
Borgwardt, S. J., Riecher-Rössler, A., Dazzan, P., Chitnis, X., Aston, J., Drewe, M., ... McGuire, P. K. (2007). Regional gray matter volume abnormalities in the at risk mental state. Biological Psychiatry, 61(10), pp. 1148-56.
Borgwardt SJ, et al. Regional Gray Matter Volume Abnormalities in the at Risk Mental State. Biol Psychiatry. 2007 May 15;61(10):1148-56. PubMed PMID: 17098213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regional gray matter volume abnormalities in the at risk mental state. AU - Borgwardt,Stefan J, AU - Riecher-Rössler,Anita, AU - Dazzan,Paola, AU - Chitnis,Xavier, AU - Aston,Jacqueline, AU - Drewe,Margret, AU - Gschwandtner,Ute, AU - Haller,Sven, AU - Pflüger,Marlon, AU - Rechsteiner,Evelyne, AU - D'Souza,Marcus, AU - Stieglitz,Rolf-Dieter, AU - Radü,Ernst-Wilhelm, AU - McGuire,Philip K, Y1 - 2006/11/13/ PY - 2006/06/02/received PY - 2006/07/11/revised PY - 2006/08/04/accepted PY - 2006/11/14/pubmed PY - 2007/8/2/medline PY - 2006/11/14/entrez SP - 1148 EP - 56 JF - Biological psychiatry JO - Biol. Psychiatry VL - 61 IS - 10 N2 - BACKGROUND: Individuals with an At Risk Mental State (ARMS) have a very high risk of developing a psychotic disorder but the basis of this risk is unclear. We addressed this issue by studying gray matter volume in this group with magnetic resonance imaging (MRI). METHODS: Thirty-five individuals with an ARMS, 25 patients with first episode schizophrenia, and 22 healthy volunteers were studied using a 1.5T MRI scanner. Twelve (34%) of the ARMS group developed schizophrenia in the 2 years subsequent to scanning. RESULTS: There were significant volumetric differences between the three groups in the left insula, superior temporal gyrus, cingulate gyrus and precuneus. In these regions, the volume in the ARMS group was smaller than in volunteers but not significantly different from that in the first episode (FE) group. Direct comparison of the ARMS and control groups revealed additional areas of reduced volume in the left medial temporal cortex. Within the ARMS group, those subjects who later developed psychosis had less gray matter than subjects who did not in the right insula, inferior frontal and superior temporal gyrus. CONCLUSIONS: The ARMS was associated with reductions in gray matter volume in areas that are also reduced in schizophrenia, suggesting that these are a correlate of an increased vulnerability to psychosis. Volumetric differences within the ARMS group may be related to the subsequent onset of schizophrenia in a subset of those at high risk. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/17098213/Regional_gray_matter_volume_abnormalities_in_the_at_risk_mental_state_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(06)01010-9 DB - PRIME DP - Unbound Medicine ER -