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Minimal decrease in hot flashes desired by postmenopausal women in family practice.

Abstract

OBJECTIVE

To determine the minimal important difference in the frequency and severity of hot flashes that postmenopausal women desire from a nonhormonal agent.

DESIGN

Women recorded their number of hot flashes daily, along with their degree of severity, using a diary for 1 week and completed the Menopause-Specific Quality of Life Questionnaire. Women were asked to report the percentage reduction in hot flashes that they would find clinically important. Distribution-based estimates were used to estimate the minimal important difference.

RESULTS

Approximately 69% of the postmenopausal women who reported their hot flashes as moderate to severe responded that they wanted a nonhormonal agent that provided at least a 50% mean reduction in the frequency of hot flashes (95% CI, 32% to 66%). Median hot flash reduction for all respondents was 50%.

CONCLUSIONS

The minimal clinically important difference in hot flashes is approximately 50%. This estimate can provide the basis to calculate sample size in clinical trials of anti-hot flash agents and in selecting possible candidates for investigation.

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  • Authors+Show Affiliations

    ,

    Scarborough Hospital, Department of Family and Community Medicine, University of Toronto, Ontario, Canada. dbutt@tsh.to

    , ,

    Source

    MeSH

    Aged
    Estrogen Replacement Therapy
    Family Practice
    Female
    Hot Flashes
    Humans
    Incidence
    Menopause
    Middle Aged
    Ontario
    Patient Acceptance of Health Care
    Patient Satisfaction
    Postmenopause
    Quality of Life
    Severity of Illness Index

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17099324

    Citation

    Butt, Debra A., et al. "Minimal Decrease in Hot Flashes Desired By Postmenopausal Women in Family Practice." Menopause (New York, N.Y.), vol. 14, no. 2, 2007, pp. 203-7.
    Butt DA, Deng LY, Lewis JE, et al. Minimal decrease in hot flashes desired by postmenopausal women in family practice. Menopause. 2007;14(2):203-7.
    Butt, D. A., Deng, L. Y., Lewis, J. E., & Lock, M. (2007). Minimal decrease in hot flashes desired by postmenopausal women in family practice. Menopause (New York, N.Y.), 14(2), pp. 203-7.
    Butt DA, et al. Minimal Decrease in Hot Flashes Desired By Postmenopausal Women in Family Practice. Menopause. 2007;14(2):203-7. PubMed PMID: 17099324.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Minimal decrease in hot flashes desired by postmenopausal women in family practice. AU - Butt,Debra A, AU - Deng,Linda Y R, AU - Lewis,Jacqueline E, AU - Lock,Michael, PY - 2006/11/14/pubmed PY - 2007/6/22/medline PY - 2006/11/14/entrez SP - 203 EP - 7 JF - Menopause (New York, N.Y.) JO - Menopause VL - 14 IS - 2 N2 - OBJECTIVE: To determine the minimal important difference in the frequency and severity of hot flashes that postmenopausal women desire from a nonhormonal agent. DESIGN: Women recorded their number of hot flashes daily, along with their degree of severity, using a diary for 1 week and completed the Menopause-Specific Quality of Life Questionnaire. Women were asked to report the percentage reduction in hot flashes that they would find clinically important. Distribution-based estimates were used to estimate the minimal important difference. RESULTS: Approximately 69% of the postmenopausal women who reported their hot flashes as moderate to severe responded that they wanted a nonhormonal agent that provided at least a 50% mean reduction in the frequency of hot flashes (95% CI, 32% to 66%). Median hot flash reduction for all respondents was 50%. CONCLUSIONS: The minimal clinically important difference in hot flashes is approximately 50%. This estimate can provide the basis to calculate sample size in clinical trials of anti-hot flash agents and in selecting possible candidates for investigation. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/17099324/Minimal_decrease_in_hot_flashes_desired_by_postmenopausal_women_in_family_practice_ L2 - http://Insights.ovid.com/pubmed?pmid=17099324 DB - PRIME DP - Unbound Medicine ER -