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Boosting effect of purified chick embryo cell rabies vaccine using the intradermal route in persons previously immunized by the intramuscular route or vice versa.
Natl Med J India. 2006 Jul-Aug; 19(4):192-4.NM

Abstract

BACKGROUND

At present, in the event of re-exposure to rabies, 2 booster doses are recommended for people who have been previously vaccinated with cell culture rabies vaccines by the conventional intramuscular route. As the intradermal route of vaccination is likely to be introduced in the future, we investigated the immune response to a cell culture rabies vaccine after crossing over from the intramuscular to the intradermal route and vice versa.

METHODS

Twenty healthy adult volunteers who had received a primary course of rabies vaccination with purified chick embryo cell rabies vaccine by either the intramuscular (n = 10) or intradermal (n = 10) route received booster vaccination with the same vaccine by the alternative route. The regimen used was 0.1 ml of vaccine by the intradermal route at two sites (deltoid area) for the intramuscular group, or 1 ml of vaccine by the intramuscular route (deltoid muscle) to the intradermal group on days 0 and 3.

RESULTS

There was a 15-fold rise in the rabies virus neutralizing antibody response both by the intradermal and intramuscular routes of booster vaccination (p < 0.0001). Thus, the change of route of purified chick embryo cell booster vaccination did not alter the anamnestic immune response to the vaccine. No side-effects were observed after vaccination with either of the routes.

CONCLUSION

Purified chick embryo cell vaccine was found to be safe and immunologically efficacious following booster vaccination after cross-over from the intradermal to the intramuscular route and vice versa.

Authors+Show Affiliations

Department of Community Medicine, Kempegowda Institute of Medical Sciences, K.R. Road, V.V. Puram, Bangalore 560004, Karnataka, India. mksudarshan@vsnl.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17100105

Citation

Sudarshan, M K., et al. "Boosting Effect of Purified Chick Embryo Cell Rabies Vaccine Using the Intradermal Route in Persons Previously Immunized By the Intramuscular Route or Vice Versa." The National Medical Journal of India, vol. 19, no. 4, 2006, pp. 192-4.
Sudarshan MK, Madhusudana SN, Mahendra BJ, et al. Boosting effect of purified chick embryo cell rabies vaccine using the intradermal route in persons previously immunized by the intramuscular route or vice versa. Natl Med J India. 2006;19(4):192-4.
Sudarshan, M. K., Madhusudana, S. N., Mahendra, B. J., Narayana, D. H., Giri, M. S., Muhamuda, K., Ravish, H. S., & Venkatesh, G. M. (2006). Boosting effect of purified chick embryo cell rabies vaccine using the intradermal route in persons previously immunized by the intramuscular route or vice versa. The National Medical Journal of India, 19(4), 192-4.
Sudarshan MK, et al. Boosting Effect of Purified Chick Embryo Cell Rabies Vaccine Using the Intradermal Route in Persons Previously Immunized By the Intramuscular Route or Vice Versa. Natl Med J India. 2006 Jul-Aug;19(4):192-4. PubMed PMID: 17100105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Boosting effect of purified chick embryo cell rabies vaccine using the intradermal route in persons previously immunized by the intramuscular route or vice versa. AU - Sudarshan,M K, AU - Madhusudana,S N, AU - Mahendra,B J, AU - Narayana,D H Ashwath, AU - Giri,M S Ananda, AU - Muhamuda,K, AU - Ravish,H S, AU - Venkatesh,G M, PY - 2006/11/15/pubmed PY - 2006/12/9/medline PY - 2006/11/15/entrez SP - 192 EP - 4 JF - The National medical journal of India JO - Natl Med J India VL - 19 IS - 4 N2 - BACKGROUND: At present, in the event of re-exposure to rabies, 2 booster doses are recommended for people who have been previously vaccinated with cell culture rabies vaccines by the conventional intramuscular route. As the intradermal route of vaccination is likely to be introduced in the future, we investigated the immune response to a cell culture rabies vaccine after crossing over from the intramuscular to the intradermal route and vice versa. METHODS: Twenty healthy adult volunteers who had received a primary course of rabies vaccination with purified chick embryo cell rabies vaccine by either the intramuscular (n = 10) or intradermal (n = 10) route received booster vaccination with the same vaccine by the alternative route. The regimen used was 0.1 ml of vaccine by the intradermal route at two sites (deltoid area) for the intramuscular group, or 1 ml of vaccine by the intramuscular route (deltoid muscle) to the intradermal group on days 0 and 3. RESULTS: There was a 15-fold rise in the rabies virus neutralizing antibody response both by the intradermal and intramuscular routes of booster vaccination (p < 0.0001). Thus, the change of route of purified chick embryo cell booster vaccination did not alter the anamnestic immune response to the vaccine. No side-effects were observed after vaccination with either of the routes. CONCLUSION: Purified chick embryo cell vaccine was found to be safe and immunologically efficacious following booster vaccination after cross-over from the intradermal to the intramuscular route and vice versa. SN - 0970-258X UR - https://www.unboundmedicine.com/medline/citation/17100105/Boosting_effect_of_purified_chick_embryo_cell_rabies_vaccine_using_the_intradermal_route_in_persons_previously_immunized_by_the_intramuscular_route_or_vice_versa_ L2 - http://www.diseaseinfosearch.org/result/6131 DB - PRIME DP - Unbound Medicine ER -