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The endocannabinoid system in ageing: a new target for drug development.
Curr Drug Targets 2006; 7(11):1539-52CD

Abstract

Endocannabinoids are a new class of lipids, which include amides, esters and ethers of long chain polyunsaturated fatty acids. Anandamide (N-arachidonoylethanolamine; AEA) and 2-arachidonoylglycerol are the main endogenous agonists of cannabinoid receptors able to mimic several pharmacological effects of Delta(9)-tetrahydrocannabinol, the active principle of Cannabis sativa preparations like hashish and marijuana. AEA is released "on demand" from membrane lipids, and its activity at the receptors is limited by cellular uptake followed by intracellular hydrolysis. Together with AEA and congeners, the proteins which bind, synthesize, transport and hydrolyze AEA form the "endocannabinoid system". Endogenous cannabinoids are present in the central nervous system and in peripheral tissues, suggesting a physiological role as broad spectrum modulators. This review summarizes the main features of the endocannabinoid system, and the latest advances on its involvement in ageing of central and peripheral cells. In addition, the therapeutic potential of recently developed drugs able to modulate the endocannabinoid tone for the treatment of ageing and age-related human pathologies will be reviewed.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Teramo, Piazza A. Moro 45, 64100 Teramo, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17100593

Citation

Paradisi, A, et al. "The Endocannabinoid System in Ageing: a New Target for Drug Development." Current Drug Targets, vol. 7, no. 11, 2006, pp. 1539-52.
Paradisi A, Oddi S, Maccarrone M. The endocannabinoid system in ageing: a new target for drug development. Curr Drug Targets. 2006;7(11):1539-52.
Paradisi, A., Oddi, S., & Maccarrone, M. (2006). The endocannabinoid system in ageing: a new target for drug development. Current Drug Targets, 7(11), pp. 1539-52.
Paradisi A, Oddi S, Maccarrone M. The Endocannabinoid System in Ageing: a New Target for Drug Development. Curr Drug Targets. 2006;7(11):1539-52. PubMed PMID: 17100593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The endocannabinoid system in ageing: a new target for drug development. AU - Paradisi,A, AU - Oddi,S, AU - Maccarrone,M, PY - 2006/11/15/pubmed PY - 2007/1/5/medline PY - 2006/11/15/entrez SP - 1539 EP - 52 JF - Current drug targets JO - Curr Drug Targets VL - 7 IS - 11 N2 - Endocannabinoids are a new class of lipids, which include amides, esters and ethers of long chain polyunsaturated fatty acids. Anandamide (N-arachidonoylethanolamine; AEA) and 2-arachidonoylglycerol are the main endogenous agonists of cannabinoid receptors able to mimic several pharmacological effects of Delta(9)-tetrahydrocannabinol, the active principle of Cannabis sativa preparations like hashish and marijuana. AEA is released "on demand" from membrane lipids, and its activity at the receptors is limited by cellular uptake followed by intracellular hydrolysis. Together with AEA and congeners, the proteins which bind, synthesize, transport and hydrolyze AEA form the "endocannabinoid system". Endogenous cannabinoids are present in the central nervous system and in peripheral tissues, suggesting a physiological role as broad spectrum modulators. This review summarizes the main features of the endocannabinoid system, and the latest advances on its involvement in ageing of central and peripheral cells. In addition, the therapeutic potential of recently developed drugs able to modulate the endocannabinoid tone for the treatment of ageing and age-related human pathologies will be reviewed. SN - 1873-5592 UR - https://www.unboundmedicine.com/medline/citation/17100593/The_endocannabinoid_system_in_ageing:_a_new_target_for_drug_development_ L2 - http://www.eurekaselect.com/58148/article DB - PRIME DP - Unbound Medicine ER -